Harnessing cellular therapeutics for type 1 diabetes mellitus: progress, challenges, and the road ahead.

Autor: Grattoni A; Department of Nanomedicine, Houston Methodist Research Institute, Houston, TX, USA. agrattoni@houstonmethodist.org.; Department of Surgery, Houston Methodist Hospital, Houston, TX, USA. agrattoni@houstonmethodist.org.; Department of Radiation Oncology, Houston Methodist Hospital, Houston, TX, USA. agrattoni@houstonmethodist.org., Korbutt G; Alberta Diabetes Institute, University of Alberta, Edmonton, Alberta, Canada.; Department of Surgery, University of Alberta, Edmonton, Alberta, Canada., Tomei AA; Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Biomedical Engineering, University of Miami, Miami, FL, USA.; Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Microbiology and Immunology, University of Miami Miller School of Medicine, Miami, FL, USA., García AJ; Woodruff School of Mechanical Engineering and Petit Institute for Bioengineering and Bioscience, Georgia Institute of Technology, Atlanta, GA, USA., Pepper AR; Department of Surgery, University of Alberta, Edmonton, Alberta, Canada., Stabler C; J. Crayton Pruitt Family Department of Biomedical Engineering, Herbert Wertheim College of Engineering, University of Florida, Gainesville, FL, USA.; Diabetes Institute, University of Florida, Gainesville, FL, USA., Brehm M; Program in Molecular Medicine, Diabetes Center of Excellence, University of Massachusetts Chan Medical School, Worcester, MA, USA., Papas K; Department of Surgery, The University of Arizona, Tucson, AZ, USA., Citro A; Diabetes Research Institute, IRCCS Ospedale San Raffaele, Milan, Italy., Shirwan H; Department of Pediatrics, Ellis Fischel Cancer Center, School of Medicine, University of Missouri, Columbia, MO, USA., Millman JR; Division of Endocrinology, Metabolism and Lipid Research, Washington University School of Medicine, St. Louis, MO, USA.; Department of Biomedical Engineering, Washington University in St. Louis, St. Louis, MO, USA., Melero-Martin J; Department of Cardiac Surgery, Boston Children's Hospital, Boston, MA, USA.; Department of Surgery, Harvard Medical School, Boston, MA, USA.; Harvard Stem Cell Institute, Cambridge, MA, USA., Graham M; Department of Surgery, University of Minnesota, Minneapolis, MN, USA.; Department of Veterinary Population Medicine, University of Minnesota, St. Paul, MN, USA., Sefton M; Institute of Biomedical Engineering, University of Toronto, Toronto, Ontario, Canada.; Department of Chemical Engineering and Applied Chemistry, University of Toronto, Toronto, Ontario, Canada., Ma M; Department of Biological and Environmental Engineering, Cornell University, Ithaca, NY, USA., Kenyon N; Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA., Veiseh O; Department of Bioengineering, Rice University, Houston, TX, USA., Desai TA; University of California, San Francisco, Department of Bioengineering and Therapeutic Sciences, San Francisco, CA, USA.; Brown University, School of Engineering, Providence, RI, USA., Nostro MC; McEwen Stem Cell Institute, University Health Network, Toronto, ON, Canada.; Department of Physiology, University of Toronto, Toronto, ON, Canada., Marinac M; Advocacy Department, Breakthrough T1D, Washington, DC, USA., Sykes M; Department of Medicine, Columbia Center for Translational Immunology, Columbia University, New York, NY, USA.; Department of Microbiology and Immunology, Columbia University, New York, NY, USA.; Department of Surgery, Columbia University, New York, NY, USA., Russ HA; Diabetes Institute, University of Florida, Gainesville, FL, USA.; Department of Pharmacology and Therapeutics, University of Florida, Gainesville, FL, USA., Odorico J; UW Health Transplant Center, Madison, WI, USA.; Division of Transplantation, Department of Surgery, University of Wisconsin School of Medicine and Public Health, Madison, WI, USA., Tang Q; Diabetes Center, University of California San Francisco, San Francisco, CA, USA.; Department of Surgery, University of California San Francisco, San Francisco, CA, US.; Gladstone Institute of Genomic Immunology, University of California San Francisco, San Francisco, CA, USA., Ricordi C; Diabetes Research Institute, University of Miami Miller School of Medicine, Miami, FL, USA.; Department of Surgery, University of Miami Miller School of Medicine, Miami, FL, USA., Latres E; Research Department, Breakthrough T1D, New York, NY, USA., Mamrak NE; Research Department, Breakthrough T1D, New York, NY, USA., Giraldo J; Research Department, Breakthrough T1D, New York, NY, USA. jgiraldo@breakthrought1d.org., Poznansky MC; Vaccine and Immunotherapy Center, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA. mark_poznansky@dfci.harvard.edu., de Vos P; Immunoendocrinology, Division of Medical Biology, Department of Pathology and Medical Biology, University of Groningen and University Medical Center Groningen, Groningen, Netherlands. p.de.vos@umcg.nl.

Publikováno v: Nature reviews. Endocrinology [Nat Rev Endocrinol] 2024 Sep 03. Date of Electronic Publication: 2024 Sep 03.

Synthetic regulatory reconstitution reveals principles of mammalian Hox cluster regulation.

Autor: Pinglay S; Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA., Bulajić M; Department of Biology, New York University, New York, NY 10003, USA., Rahe DP; Department of Biology, New York University, New York, NY 10003, USA., Huang E; Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA., Brosh R; Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA., Mamrak NE; Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA., King BR; Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA., German S; Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA., Cadley JA; Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA., Rieber L; Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA., Easo N; Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA., Lionnet T; Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.; Department of Cell Biology, NYU Langone Health, New York, NY 10016, USA.; Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn, NY 11201, USA., Mahony S; Center for Eukaryotic Gene Regulation, Department of Biochemistry and Molecular Biology, Pennsylvania State University, University Park, PA 16802, USA., Maurano MT; Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.; Department of Pathology, NYU Langone Health, New York, NY 10016, USA., Holt LJ; Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.; Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn, NY 11201, USA.; Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA., Mazzoni EO; Department of Biology, New York University, New York, NY 10003, USA., Boeke JD; Institute for Systems Genetics, NYU Langone Health, New York, NY 10016, USA.; Department of Biomedical Engineering, NYU Tandon School of Engineering, Brooklyn, NY 11201, USA.; Department of Biochemistry and Molecular Pharmacology, NYU Langone Health, New York, NY 10016, USA.

Publikováno v: Science (New York, N.Y.) [Science] 2022 Jul; Vol. 377 (6601), pp. eabk2820. Date of Electronic Publication: 2022 Jul 01.

Recent discoveries in the molecular pathogenesis of the inherited bone marrow failure syndrome Fanconi anemia.

Autor: Mamrak NE; Department of Cell and Molecular Biology, University of Rhode Island, 120 Flagg Road, Kingston, RI 02881, United States. Electronic address: nicholasmamrak@my.uri.edu., Shimamura A; Dana-Farber Cancer Institute/Boston Children's Cancer and Blood Disorders Center, Boston, MA 02215, United States. Electronic address: akiko.shimamura@childrens.harvard.edu., Howlett NG; Department of Cell and Molecular Biology, University of Rhode Island, 120 Flagg Road, Kingston, RI 02881, United States. Electronic address: nhowlett@uri.edu.

Publikováno v: Blood reviews [Blood Rev] 2017 May; Vol. 31 (3), pp. 93-99. Date of Electronic Publication: 2016 Oct 13.