Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Mamoru matsuura"'
Autor:
Michihiro Mutoh, Naoko Niho, Mami Takahashi, Mamoru Matsuura, Tomohiro Kitamura, Keiji Wakabayashi, Takashi Sugimura, Hidetaka Sato
Publikováno v:
Cancer Science. 97:1011-1014
We demonstrated recently that mofezolac, a cyclooxygenase-1 (COX-1) selective inhibitor, suppresses the development of azoxymethane (AOM)-induced colonic aberrant crypt foci in F344 rats and intestinal polyps in APC1309 mice. In the present study, we
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 5:959-962
Several alkyl-analogues of pranoprofen were synthesized and their cyclooxygenase inhibitory activities were evaluated in a screening test. The chosen compounds were analyzed on the relationships between structure, lipophilicity (log P) and cell bindi
Publikováno v:
International journal of cancer. 109(4)
As with cyclooxygenase (COX)-2, genetic disruption of COX-1 gene or pharmacologic inhibition of its activity has been shown to decrease the number of intestinal polyps in Apc gene-deficient mice. The present study was designed to investigate the comb
Autor:
Mamoru Matsuura, Toshihiko Kawamori, Naoaki Uchiya, Takashi Sugimura, Tomohiro Kitamura, Keiji Wakabayashi, Tetsuo Noda, Masaki Itoh
Publikováno v:
Carcinogenesis. 23(9)
Cyclooxygenase (COX)-2, one enzyme isoform responsible for producing prostanoids from arachidonic acid, contributes to colon carcinogenesis. Recently, genetic disruption of COX-1, the other isoform, was shown to decrease the number of intestinal poly
Publikováno v:
International journal of immunopharmacology. 22(4)
The anti-arthritic effect of FTY720, 2-amino-2-[2-(4-octylphenyl)ethyl]propane-1,3-diol hydrochloride, a novel immunosuppressant which induces peripheral lymphocyte homing to peripheral lymph nodes, was compared with those of anti-rheumatic compounds
Autor:
Tomonori Imayoshi, Hirofumi Matsui, Takeki Okumoto, Hidenobu Kusuhara, Hirofumi Matsuyuki, Mamoru Matsuura
Publikováno v:
European journal of pharmacology. 360(2-3)
Nonsteroidal anti-inflammatory drugs (NSAIDs) have been shown to cause apoptosis in several cell lines including transformed chicken embryo fibroblasts and human colon cancer cells. We herein report the apoptotic effect of NSAIDs in a non-transformed
Autor:
Michio Terasawa, Yukihiro Yasunaga, Noriko Tomomatsu, Hiroshi Ochi, Mamoru Matsuura, Kazuko Gotoh, Tomonori Imayoshi
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 106(4)
The analgesic mechanism of Y-23023, a new non-steroidal anti-inflammatory drug, was investigated in the writhing response induced by intraperitoneal injection of kaolin and captopril in mice. Y-23023 (0.1-1 mg/kg, p.o.) suppressed the writhing freque
Autor:
Michio Terasawa, Yoshinori Iwahisa, Tomonori Imayoshi, Mamoru Matsuura, Yukihiro Yasunaga, Hiroshi Ochi
Publikováno v:
Nihon yakurigaku zasshi. Folia pharmacologica Japonica. 106(2)
The analgesic and anti-inflammatory activities of Y-23023, a new nonsteroidal analgesic and anti-inflammatory compound, were investigated in acute, subacute and chronic pain models in rats. In the carrageenin paw edema test, Y-23023 (0.3-3 mg/kg, p.o
Publikováno v:
NIPPON SUISAN GAKKAISHI. 55:135-141
An aerogenic Vibrio strain Yp-16 was isolated from diseased young fish of yellowtail Seriola quinqueradiata cultured in Shibushi Bay, Japan. On the basis of specific characters such as O/129 sensitivity, lysine decarboxylase (-), indole (-), casein h
Publikováno v:
FOOD IRRADIATION, JAPAN. 3:104-110