Výsledky vyhledávání - "Mamoru Yanagimachi"

Akademický článek

Squalene synthase inhibitors suppress triglyceride biosynthesis through the farnesol pathway in rat hepatocytes

Autor: Hironobu Hiyoshi, Mamoru Yanagimachi, Masashi Ito, Nobuyuki Yasuda, Toshimi Okada, Hironori Ikuta, Daisuke Shinmyo, Keigo Tanaka, Nobuyuki Kurusu, Ichiro Yoshida, Shinya Abe, Takao Saeki, Hiroshi Tanaka

Publikováno v: Journal of Lipid Research, Vol 44, Iss 1, Pp 128-135 (2003)

We recently demonstrated that squalene synthase (S111111148) inhibitors reduce plasma triglyceride through an LDL receptor-independent mechanism in Watanabe heritable hyperlipidemic rabbits (Hiyoshi et al. 2001. Eur. J. Pharmacol. 431: 345–352). Th

Externí odkaz: https://doaj.org/article/68795c48eefe49edb03dfb9508144b44

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Akademický článek

Effect of ER-27856, a novel squalene synthase inhibitor, on plasma cholesterol in rhesus monkeys: comparison with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors

Autor: Hironobu Hiyoshi, Mamoru Yanagimachi, Masashi Ito, Issei Ohtsuka, Ichiro Yoshida, Takao Saeki, Hiroshi Tanaka

Publikováno v: Journal of Lipid Research, Vol 41, Iss 7, Pp 1136-1144 (2000)

Squalene synthase (SQS; EC 2.5.1.21) plays an important role in the cholesterol biosynthetic pathway. We discovered ER-28448, 5-{N-[2-butenyl-3-(2-methoxyphenyl)]-N-methylamino}-1,1-penthylidenebis(phosphonic acid) trisodium salt, as a potent and sel

Externí odkaz: https://doaj.org/article/c488480de13e4da6bc0e961a92cf81e1

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Akademický článek

Circulating miRNA biomarkers for Alzheimer's disease.

Autor: Pavan Kumar, Zoltan Dezso, Crystal MacKenzie, Judy Oestreicher, Sergei Agoulnik, Michael Byrne, Francois Bernier, Mamoru Yanagimachi, Ken Aoshima, Yoshiya Oda

Publikováno v: PLoS ONE, Vol 8, Iss 7, p e69807 (2013)

A minimally invasive diagnostic assay for early detection of Alzheimer's disease (AD) is required to select optimal patient groups in clinical trials, monitor disease progression and response to treatment, and to better plan patient clinical care. Bl

Externí odkaz: https://doaj.org/article/d506b339c5284f2390f8cbdf863dd996

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GP-001, a Facility-Randomized, Open-Label, Cross-Over Study to Evaluate the Effect of Pecan on Caregiver Burden Score in Nursing Care Facility for Dementia Person

Autor: Mikiko Irisawa, Atsushi Iwata, Akira Mizuno, Mamoru Yanagimachi, Yasuhiro Sasaki

Publikováno v: Curr Dev Nutr

OBJECTIVES: Tree nuts such as pecan (Carya illinoinensis) have been thought to be possible dietary interventions for not only cardiovascular and metabolic disorders but also age-related brain disorders. The aim of this study was to understand the use

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f347dd2b4020613ba0d8a62a6acaf6ba
https://europepmc.org/articles/PMC7257944/

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Effect of ER-27856, a novel squalene synthase inhibitor, on plasma cholesterol in rhesus monkeys: comparison with 3-hydroxy-3-methylglutaryl-CoA reductase inhibitors

Autor: Masashi Ito, Ichiro Yoshida, Hironobu Hiyoshi, Mamoru Yanagimachi, Hiroshi Tanaka, Takao Saeki, Issei Ohtsuka

Publikováno v: Journal of Lipid Research, Vol 41, Iss 7, Pp 1136-1144 (2000)

Squalene synthase (SQS; EC 2.5.1.21) plays an important role in the cholesterol biosynthetic pathway. We discovered ER-28448, 5-(N-[2-butenyl-3-(2-methoxyphenyl)]-N-methylamino)-1, 1-penthylidenebis(phosphonic acid) trisodium salt, as a potent and se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84666d972c1e5831e3bacb84ddd58664
http://www.sciencedirect.com/science/article/pii/S0022227520320204

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Antibody to Thrombin Receptor Inhibits Neointimal Smooth Muscle Cell Accumulation Without Causing Inhibition of Platelet Aggregation or Altering Hemostatic Parameters After Angioplasty in Rat

Autor: Shinji Yoshitake, Toshie Yamada, Takashi Musha, Mamoru Yanagimachi, Motoji Kogushi, Hiroko Kobayashi, Takanori Kawamura, Osamu Ito, Hiroshi Tanaka, Masashi Ito, Masahiro Takada, Isao Saito, Fusayo Yoshida

Publikováno v: Circulation Research. 82:980-987

Abstract —An antibody was raised in rabbits against SFFLRNPSEDTFEQF peptide, which is an NH 2 -terminal peptide of the thrombin-cleaved rat thrombin receptor. In vitro, the antibody inhibited rat smooth muscle cell proliferation but had no effect o

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::53c6502797c4aff74d7561cd71d3bb15
https://doi.org/10.1161/01.res.82.9.980

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