Výsledky vyhledávání - "Mammary Tumor Virus, Mouse/immunology"

Viral Superantigen Drives Extrafollicular and Follicular B Cell Differentiation Leading to Virus-specific Antibody Production

Autor: Sanjiv A. Luther, Ian C. M. MacLennan, Hans Acha-Orbea, Adam Gulbranson-Judge

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 185, no. 3, pp. 551-562

Mouse mammary tumor virus (MMTV[SW]) encodes a superantigen expressed by infected B cells. It evokes an antibody response specific for viral envelope protein, indicating selective activation of antigen-specific B cells. The response to MMTV(SW) in dr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b5fa4d8a2f0f41a5395b21612f0e96f
http://europepmc.org/articles/PMC2196032

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T cell receptor Vβ repertoire in mice lacking endogenous mouse mammary tumor provirus

Autor: Hans Acha-Orbea, Patrice N. Marche, Michel Y Braun, Evelyne Jouvin-Marche, H R MacDonald

Publikováno v: European Journal of Immunology, 25 (3

When endogenous mouse mammary tumor virus (MMTV) superantigens (SAg) are expressed in the first weeks of life an efficient thymic deletion of T cells expressing MMTV SAg-reactive T cell receptor (TcR) V beta segments is observed. As most inbred mouse

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e7167226af69bef49f14688b5c6a79c0
https://doi.org/10.1002/eji.1830250334

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Retroviral infection of neonatal Peyer's patch lymphocytes: the mouse mammary tumor virus model

Autor: H Acha-Orbea, A N Shakhov, Jean-Pierre Kraehenbuhl, O Karapetian

Publikováno v: Journal of Experimental Medicine, vol. 180, no. 4, pp. 1511-1516
The Journal of Experimental Medicine

Mouse mammary tumor virus is known to infect newborn mice via mother's milk. A proposed key step for viral spread to the mammary gland is by the infection of lymphocytes. We show here that although in suckling mice retroviral proteins are found in al

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::28daf57c04eb1a60497b8e84f50f8667
https://doi.org/10.1084/jem.180.4.1511

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Superantigen-reactive CD4+ T cells are required to stimulate B cells after infection with mouse mammary tumor virus

Autor: Hans Acha-Orbea, H R MacDonald, A N Shakhov, Shozo Izui, Leonardo Scarpellino, Werner Held, Gary A. Waanders

Publikováno v: Journal of Experimental Medicine, vol. 177, no. 2, pp. 359-366
The Journal of Experimental Medicine
Journal of Experimental Medicine, Vol. 177, No 2 (1993) pp. 359-366

Superantigens are defined by their ability to stimulate a large fraction of T cells via interaction with the T cell receptor (TCR) V beta domain. Endogenous superantigens, classically termed minor lymphocyte-stimulating (Mls) antigens, were recently

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e4832135b6cc10ec5e082b3970fb1dc8
https://doi.org/10.1084/jem.177.2.359

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Development of T-B cell collaboration in neonatal mice

Autor: Hans Acha-Orbea, Ochine Karapetian, Daniela Finke, Mireille Astori

Publikováno v: International Immunology, vol. 11, no. 3, pp. 445-451

The neonatal immune response is impaired during the first weeks after birth. To obtain a better understanding of this immaturity, we investigated the development of T cell interactions with B cells in mice. For this purpose, we analyzed the immune re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fefc071f8a1193ec4f47cedd0653e398
https://pubmed.ncbi.nlm.nih.gov/10221656

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T helper 1 (Th1) and Th2 characteristics start to develop during T cell priming and are associated with an immediate ability to induce immunoglobulin class switching

Autor: Sanjiv A. Luther, Kai-Michael Toellner, Richard K.-W. Choy, Daniel Man-Yuen Sze, Hans Acha-Orbea, Dale R. Taylor, Ian C. M. MacLennan

Publikováno v: The Journal of Experimental Medicine
Journal of Experimental Medicine, vol. 187, no. 8, pp. 1193-1204

The respective production of specific immunoglobulin (Ig)G2a or IgG1 within 5 d of primary immunization with Swiss type mouse mammary tumor virus [MMTV(SW)] or haptenated protein provides a model for the development of T helper 1 (Th1) and Th2 respon

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1c94712a5fccd646dbb48192b8abad1b
https://pubmed.ncbi.nlm.nih.gov/9547331

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Peripheral T cell activation and deletion induced by transfer of lymphocyte subsets expressing endogenous or exogenous mouse mammary tumor virus

Autor: Gary A. Waanders, Werner Held, A N Shakhov, H R MacDonald, Hans Acha-Orbea, O Karapetian

Publikováno v: Journal of Experimental Medicine, vol. 177, no. 5, pp. 1359-1366
The Journal of Experimental Medicine

Murine T cell reactivity with products of the minor lymphocyte stimulatory (Mls) locus correlates with the expression of particular variable (V) domains of the T cell receptor (TCR) beta chain. It was recently demonstrated that Mls antigens are encod

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5ca11a746968421e33690a21f4537be7
https://serval.unil.ch/notice/serval:BIB_B02AB919714B

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Inhibition of mouse mammary tumor virus-induced T cell responses in vivo by antibodies to an open reading frame protein

Autor: Leonardo Scarpellino, H R MacDonald, A N Shakhov, Werner Held, Hans Acha-Orbea

Publikováno v: Journal of Experimental Medicine, vol. 176, no. 6, pp. 1769-1772
The Journal of Experimental Medicine

Minor lymphocyte stimulating (Mls) antigens specifically stimulate T cell responses that are restricted to particular T cell receptor (TCR) beta chain variable domains. The Mls phenotype is genetically controlled by an open reading frame (orf) locate

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6afd2edbb8d73241006d9dcd9918a0e9
https://serval.unil.ch/resource/serval:BIB_35F3DCDA65DB.P001/REF.pdf

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Nucleotide sequence of the 5′ noncoding region and part of thegaggene of mouse mammary tumor virus; identification of the 5′ splicing site for subgenomic mRNAs

Autor: J. Firzlaff, H. Diggelmann, Nicolas Fasel, E. Buetti, K. Pearson

Publikováno v: Nucleic Acids Research, vol. 11, no. 20, pp. 6943-6955

We have determined the sequence of the first 1371 nucleotides at the 5' end of the genome of mouse mammary tumor virus using molecularly cloned proviral DNA of the GR virus strain. The most likely initiation codon used for the gag gene of mouse mamma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1999efc8831f1171288db4e737bbcbfe
https://doi.org/10.1093/nar/11.20.6943

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