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pro vyhledávání: '"Mammalian Chromosomes"'
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Publikováno v:
Russian Journal of Genetics. 55:1093-1102
The study is focused on the analysis of the mechanisms underlying the formation and distribution of repeat clusters in mammalian chromosomes, as exemplified by a group of closely related species of voles of the subgenus Microtus (Microtus, Arvicolini
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::afc619d795f5aee3924edd8f1c24bdb3
https://doi.org/10.1134/s1022795419090126
https://doi.org/10.1134/s1022795419090126
Publikováno v:
Exp Cell Res
Centromeres are essential components of all eukaryotic chromosomes, including artificial/synthetic ones built in the laboratory. In humans, centromeres are typically located on repetitive α-satellite DNA, and these sequences are the "major ingredien
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bff393c03986ecb68705ea971b8852f
https://pubmed.ncbi.nlm.nih.gov/32246994
https://pubmed.ncbi.nlm.nih.gov/32246994
Publikováno v:
Frontiers in Molecular Biosciences, Vol 6 (2019)
Frontiers in Molecular Biosciences
Frontiers in Molecular Biosciences
Several orders of magnitude typically separate the contour length of eukaryotic chromosomes and the size of the nucleus where they are confined. The ensuing topological constraints can slow down the relaxation dynamics of genomic filaments to the poi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e0c29b7eff2ae7c8344cf26c9894bf95
https://www.frontiersin.org/article/10.3389/fmolb.2019.00127/full
https://www.frontiersin.org/article/10.3389/fmolb.2019.00127/full
Autor:
Guido Tiana, Luca Giorgetti
Publikováno v:
Modeling the 3D Conformation of Genomes
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b177b1a24b5ad32221c679375387cb97
https://doi.org/10.1201/9781315144009-12
https://doi.org/10.1201/9781315144009-12
Autor:
David M. Brown, John I. Glass
Publikováno v:
Experimental Cell Research. 388:111851
In the near twenty-year existence of the human and mammalian artificial chromosome field, the technologies for artificial chromosome construction and installation into desired cell types or organisms have evolved with the rest of modern molecular and
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9996c3a4ac4e66edb1e4544b4ba69ffc
https://doi.org/10.1016/j.yexcr.2020.111851
https://doi.org/10.1016/j.yexcr.2020.111851
Autor:
Guido Tiana, Luca Giorgetti
Publikováno v:
Current opinion in structural biology. 49
Eukaryotic chromosomes are complex polymers, which largely exceed in size most biomolecules that are usually modelled in computational studies and whose molecular interactions are to a large extent unknown. Since the folding of the chromatin fiber in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::076509846a8bf24500c980f8b2a87c48
https://pubmed.ncbi.nlm.nih.gov/29128709
https://pubmed.ncbi.nlm.nih.gov/29128709
Publikováno v:
Cell. 174(2)
Summary Mammalian chromosomes are partitioned into A/B compartments and topologically associated domains (TADs). The inactive X (Xi) chromosome, however, adopts a distinct conformation without evident compartments or TADs. Here, through exploration o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6500e6be05b7253946ffa9a85d5c83df
https://pubmed.ncbi.nlm.nih.gov/29887375
https://pubmed.ncbi.nlm.nih.gov/29887375
Autor:
Frank J. Steemers, Christine M. Disteche, William Stafford Noble, Kevin L. Gunderson, Jay Shendure, Zhijun Duan, Xinxian Deng, Vijay Ramani
We present combinatorial single cell Hi-C, a novel method that leverages combinatorial cellular indexing to measure chromosome conformation in large numbers of single cells. In this proof-of-concept, we generate and sequence combinatorial single cell
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9640e87dded9c65d776d4204999d5f24
Autor:
Harold R. Garner, David A. Boothman, Farjana J. Fattah, Julio C. Morales, Yunyun Zhou, Yang Xie, Praveen L. Patidar, Edward A. Motea
Publikováno v:
Nucleic Acids Research
Ku70-binding protein 5 (Kub5)-Hera (K-H)/RPRD1B maintains genetic integrity by concomitantly minimizing persistent R-loops and promoting repair of DNA double strand breaks (DSBs). We used tandem affinity purification-mass spectrometry, coimmunoprecip
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ab091990996eb04b7a580731b9d9aa3
https://hdl.handle.net/10919/88891
https://hdl.handle.net/10919/88891