Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Mamle Quarmyne"'
Autor:
Yurun Zhang, Martina Roos, Heather Himburg, Christina M. Termini, Mamle Quarmyne, Michelle Li, Liman Zhao, Jenny Kan, Tiancheng Fang, Xiao Yan, Katherine Pohl, Emelyne Diers, Hyo Jin Gim, Robert Damoiseaux, Julian Whitelegge, William McBride, Michael E. Jung, John P. Chute
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Protein tyrosine phosphatase sigma (PTPσ) deficient haematopoietic stem cells (HSCs) demonstrate increased engraftment following transplantation. Here the authors identify a small molecule inhibitor of PTPσ that promotes murine and human haematopoi
Externí odkaz:
https://doaj.org/article/a4cd7b0d3b6b453f9917108aabe1cec2
Autor:
Xiao Yan, Heather A. Himburg, Katherine Pohl, Mamle Quarmyne, Evelyn Tran, Yurun Zhang, Tiancheng Fang, Jenny Kan, Nelson J. Chao, Liman Zhao, Phuong L. Doan, John P. Chute
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1584-1594 (2016)
Imprinted genes are differentially expressed by adult stem cells, but their functions in regulating adult stem cell fate are incompletely understood. Here we show that growth factor receptor-bound protein 10 (Grb10), an imprinted gene, regulates hema
Externí odkaz:
https://doaj.org/article/a87fd976b98a4dc39d648d93607105b6
Autor:
Heather A. Himburg, Jeffrey R. Harris, Takahiro Ito, Pamela Daher, J. Lauren Russell, Mamle Quarmyne, Phuong L. Doan, Katherine Helms, Mai Nakamura, Emma Fixsen, Gonzalo Herradon, Tannishtha Reya, Nelson J. Chao, Sheila Harroch, John P. Chute
Publikováno v:
Cell Reports, Vol 2, Iss 4, Pp 964-975 (2012)
The mechanisms through which the bone marrow (BM) microenvironment regulates hematopoietic stem cell (HSC) fate remain incompletely understood. We examined the role of the heparin-binding growth factor pleiotrophin (PTN) in regulating HSC function in
Externí odkaz:
https://doaj.org/article/054071b3bb424b4e95082e2c9af1f0b6
Autor:
Yurun Zhang, Tiancheng Fang, Katherine Pohl, Martina Roos, John P. Chute, Peter A. Scott, Anna Patricia L. Javier, Vivian Y. Chang, Paulina K. Lin, Amara Pang, Christina M. Termini, Heather A. Himburg, Xiao Yan, Liman Zhao, Lia Signaevskaia, Mamle Quarmyne, Jenny Kan
Publikováno v:
Blood
Chemotherapy and irradiation cause DNA damage to hematopoietic stem cells (HSCs), leading to HSC depletion and dysfunction and the risk of malignant transformation over time. Extrinsic regulation of HSC DNA repair is not well understood, and therapie
Autor:
Michelle Li, Liman Zhao, Heather A. Himburg, Tiancheng Fang, Yurun Zhang, Katherine Pohl, Martina Roos, Christina M. Termini, William H. McBride, Mamle Quarmyne, Robert Damoiseaux, Hyo Jin Gim, Michael E. Jung, Xiao Yan, John P. Chute, Julian P. Whitelegge, Emelyne Diers, Jenny Kan
Publikováno v:
Nature Communications, Vol 10, Iss 1, Pp 1-15 (2019)
Nature Communications
Nature communications, vol 10, iss 1
Nature Communications
Nature communications, vol 10, iss 1
Receptor type protein tyrosine phosphatase-sigma (PTPσ) is primarily expressed by adult neurons and regulates neural regeneration. We recently discovered that PTPσ is also expressed by hematopoietic stem cells (HSCs). Here, we describe small molecu
Autor:
Tiancheng Fang, Jenny Kan, Yurun Zhang, Katherine Pohl, John P. Chute, Mamle Quarmyne, Heather A. Himburg, Nelson J. Chao, Evelyn Tran, Phuong L. Doan, Xiao Yan, Liman Zhao
Publikováno v:
Cell Reports, Vol 17, Iss 6, Pp 1584-1594 (2016)
SummaryImprinted genes are differentially expressed by adult stem cells, but their functions in regulating adult stem cell fate are incompletely understood. Here we show that growth factor receptor-bound protein 10 (Grb10), an imprinted gene, regulat
Autor:
John P. Chute, Katherine Pohl, Xiao Yan, Liman Zhao, Joshua P. Sasine, Nelson J. Chao, Heather A. Himburg, Jeffrey R. Harris, Evelyn Tran, Mamle Quarmyne, Jenny Kan, Phuong L. Doan, Grace V. Hancock
The role of osteolineage cells in regulating hematopoietic stem cell (HSC) regeneration following myelosuppression is not well understood. Here we show that deletion of the pro-apoptotic genes Bak and Bax in osterix (Osx, also known as Sp7 transcript
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7fa1dfa0bce276f2b9162ecf7c7747ac
https://europepmc.org/articles/PMC5592969/
https://europepmc.org/articles/PMC5592969/
Autor:
Heather A. Himburg, Katherine Helms, Nelson J. Chao, Phuong L. Doan, Emma Fixsen, Divino Deoliviera, David G. Kirsch, John P. Chute, Jeffrey R. Harris, J. Lauren Russell, Julie M. Sullivan, Mamle Quarmyne
Publikováno v:
Nature medicine
The mechanisms that regulate hematopoietic stem cell (HSC) regeneration after myelosuppressive injury are not well understood. We identified epidermal growth factor (EGF) to be highly enriched in the bone marrow serum of mice bearing deletion of Bak
Autor:
John P. Chute, Xiao Yan, Nelson J. Chao, William H. McBride, Dennis J. Slamon, Heather A. Himburg, Eva Micewicz, Phuong L. Doan, Mamle Quarmyne
Publikováno v:
The Journal of clinical investigation, vol 124, iss 11
Hematopoietic stem cells (HSCs) are highly susceptible to ionizing radiation–mediated death via induction of ROS, DNA double-strand breaks, and apoptotic pathways. The development of therapeutics capable of mitigating ionizing radiation–induced h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13ba29ca78e312247c1a94df4c0023e8
https://escholarship.org/uc/item/8qp1h0s8
https://escholarship.org/uc/item/8qp1h0s8
Publikováno v:
Macromolecules. 36:6054-6059
The adsorption of poly(vinyl alcohol) onto hydrophobic surfaces is described. Three different commercial polymer film samples, poly(tetrafluoroethylene-co-hexafluoropropylene)(FEP), poly(ethylene terephthalate) (PET), and poly(4-methyl-1-pentene) (PM