Zobrazeno 1 - 10
of 16
pro vyhledávání: '"Mami Tei"'
Autor:
Mami Tei, Tadamitsu Kishimoto, Praveen K Dubey, Kishan K. Nyati, Yohannes Gemechu, Haruhiko Miyata, Barry Ripley, Taisuke Nakahama, David Millrine
Publikováno v:
International Immunology. 28:307-315
Thalidomide and its derivatives, collectively referred to as immunomodulatory drugs (IMiDs), are effective inhibitors of inflammation and are known to inhibit TLR-induced TNFα production. The identification of Cereblon as the receptor for these comp
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 113(38)
Immunomodulatory drugs (IMiDs) are a family of compounds derived from thalidomide. Binding of the IMiD molecule to the Lon protease Cereblon initiates the degradation of substrates via the ubiquitin proteasome pathway. Here, we show that Cereblon for
Publikováno v:
Retrovirology
HTLV-1 infection leads to adult T-cell leukemia (ATL) after long latent infection period. We have established an HTLV-1-infected humanized NOG mouse model to analyze the mechanism of ATL development. Humanized mice were inoculated with Jurkat-based H
Publikováno v:
Retrovirology
HTLV-1 infection of humanized NOG mice has been demonstrated to recapitulate the development of ATL-like symptoms within several months of infection. Infected human T-cells in these mice start to proliferate vigorously in a couple weeks after infecti
Autor:
Takaharu Ueno, Mami Tei, Kenta Tezuka, Runze Xun, Norihiro Takenouchi, Masakazu Tanaka, Jun-ichi Fujisawa
Publikováno v:
Blood. 123(3)
Human T-cell leukemia virus type 1 (HTLV-1) is causally associated with adult T-cell leukemia (ATL), an aggressive T-cell malignancy with a poor prognosis. To elucidate ATL pathogenesis in vivo, a variety of animal models have been established; howev
Publikováno v:
Retrovirology
Humanized mice (huNOG) established by the intrabone marrow transplantation of NOG-SCID mouse with CD133+ hematopoietic stem cells purified from human cord blood were infected with HTLV-1 in vivo by peritonial injection of g-ray-irradiated MT-2 cells
Autor:
Kenta Tezuka, Runze Xun, Mami Tei, Jun-ichi Fujisawa, Takaharu Ueno, Norihiro Takenouchi, Masakazu Tanaka
Publikováno v:
Retrovirology, Vol 8, Iss Suppl 1, p A14 (2011)
Retrovirology
Retrovirology
Tax has pleiotropic actions that induce proliferation and inhibit apoptosis of T-cells and thus is considered to play a critical role in leukemogenesis. However, Tax expression is frequently lost in fresh adult T-cell leukemia (ATL) cells by genetic
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America; 9/20/2016, Vol. 113 Issue 38, p10625-10630, 6p
Autor:
Millrine, David, Haruhiko Miyata, Mami Tei, Dubey, Praveen, Nyati, Kishan, Taisuke Nakahama, Yohannes Gemechu, Ripley, Barry, Tadamitsu Kishimoto
Publikováno v:
International Immunology; Jun2016, Vol. 28 Issue 6, p307-315, 9p
Autor:
Tezuka, Kenta1, Xun, Runze1, Tei, Mami1, Ueno, Takaharu1, Tanaka, Masakazu1, Takenouchi, Norihiro1, Fujisawa, Jun-ichi1 fujisawa@takii.kmu.ac.jp
Publikováno v:
Retrovirology. Jan2011 Supplement 1, Vol. 8, pA14-A14. 1p.