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pro vyhledávání: '"Mami Fujimoto"'
Autor:
Yoichi Naritomi, Aya Horiguchi, Koya Sato, Shigeru Ohta, Toru Horie, Hiroki Ohshita, Shigeyuki Kitamura, Mami Fujimoto, Akio Kawamura, Seigo Sanoh, Kazumi Sugihara, Yaichiro Kotake, Chise Tateno
Publikováno v:
Xenobiotica; the fate of foreign compounds in biological systems. 45(7)
1. We used chimeric mice (PXB mice®), which were repopulated with human hepatocytes, to evaluate their predictabilities of human pharmacokinetics. 2. The relationships of total clearance (CLt) and the volume of distribution at steady state (Vdss) be