Zobrazeno 1 - 3
of 3
pro vyhledávání: '"Mami, Sugisaki"'
Autor:
Yudai, Imai, Daisuke, Wakasugi, Ryo, Suzuki, Sota, Kato, Mami, Sugisaki, Masashi, Mima, Hiroh, Miyagawa, Mayumi, Endo, Natsuko, Fujimoto, Takuya, Fukunaga, Sayaka, Kato, Shoichi, Kuroda, Teisuke, Takahashi, Hiroyuki, Kakinuma
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 79:129050
Heparanase-1 (HPSE1) is an endo-β-d-glucuronidase that cleaves heparan sulfate proteoglycans into short-chain heparan sulfates (HS). The inhibition of HPSE1 has therapeutic potential for proteinuric diseases such as nephrotic syndrome because increa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d1989640235cab9d4f57fea5d757fd63
https://doi.org/10.1016/j.bmcl.2022.129050
https://doi.org/10.1016/j.bmcl.2022.129050
Autor:
Kato Koji, Kayo Kimura, Hiroko Koretsune, Koji Yamamoto, Fusayo Io, Lisa Okumura-Kitajima, Mami Sugisaki-Kitano, Saeko Uchida, Emi Gunji
Publikováno v:
European Journal of Pharmacology. 853:136-144
Sodium-glucose cotransporter 1 (SGLT1) is the primary transporter for glucose absorption from digested nutrients in the gastrointestinal tract. Intestinal SGLT1 inhibition reduces post-prandial hyperglycemia and enhances the increase of plasma glucag
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f6c39d0fe8309d478f0d652f212145e5
https://doi.org/10.1016/j.ejphar.2019.03.023
https://doi.org/10.1016/j.ejphar.2019.03.023
Autor:
Mami Sugisaki-Kitano, Takahiro Oi, Lisa Okumura-Kitajima, Fumiyasu Shiozawa, Yohei Kobashi, Kuroda Shoichi, Koji Yamamoto, Kenichi Kawabe, Fusayo Io, Hiroyuki Kakinuma
Publikováno v:
Bioorganic & Medicinal Chemistry. 27:394-409
A new series of C-phenyl d -glucitol derivatives was designed and synthesized, and their SGLT1 inhibitory potency and absorbability were evaluated. We also investigated whether kidney drug retention could be avoided by creating molecules with differe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37488d5508b16a2f574080611c4033b7
https://doi.org/10.1016/j.bmc.2018.12.015
https://doi.org/10.1016/j.bmc.2018.12.015