Zobrazeno 1 - 10
of 10
pro vyhledávání: '"Mamduh Khateb"'
Publikováno v:
STAR Protocols, Vol 4, Iss 1, Pp 102001- (2023)
Summary: Mouse embryonic stem cells (mESCs) can be directed to acquire cell-lineage-specific genetic programs and phenotypes by stepwise exposure to defined factors, allowing the development of in vitro models for studying disease and tissue generati
Externí odkaz:
https://doaj.org/article/b148354fd5b24355ad8da48217c414a1
Autor:
Mamduh Khateb, Nitsan Fourier, Ofer Barnea-Yizhar, Sigal Ram, Ekaterina Kovalev, Aviva Azriel, Ulfert Rand, Manabu Nakayama, Hansjörg Hauser, Lior Gepstein, Ben-Zion Levi
Publikováno v:
PLoS ONE, Vol 11, Iss 6, p e0156812 (2016)
Interferon Regulatory Factor-8 (IRF-8) serves as a key factor in the hierarchical differentiation towards monocyte/dendritic cell lineages. While much insight has been accumulated into the mechanisms essential for its hematopoietic specific expressio
Externí odkaz:
https://doaj.org/article/2319e96602e442bab6b33af6216f715e
Autor:
Xuesong Feng, A. Hongjun Wang, Aster H. Juan, Kyung Dae Ko, Kan Jiang, Giulia Riparini, Veronica Ciuffoli, Aissah Kaba, Christopher Lopez, Faiza Naz, Michal Jarnik, Elizabeth Aliberti, Shenyuan Hu, Jessica Segalés, Mamduh Khateb, Natalia Acevedo-Luna, Davide Randazzo, Tom H. Cheung, Pura Muñoz-Cánoves, Stefania Dell’Orso, Vittorio Sartorelli
Publikováno v:
Developmental Cell.
Publikováno v:
STAR protocols. 4(1)
Mouse embryonic stem cells (mESCs) can be directed to acquire cell-lineage-specific genetic programs and phenotypes by stepwise exposure to defined factors, allowing the development of in vitro models for studying disease and tissue generation. In th
Autor:
Mamduh Khateb, Jelena Perovanovic, Kyung Dae Ko, Kan Jiang, Xuesong Feng, Natalia Acevedo-Luna, Jérome Chal, Veronica Ciuffoli, Pavol Genzor, James Simone, Astrid D. Haase, Olivier Pourquié, Stefania Dell’Orso, Vittorio Sartorelli
Publikováno v:
Cell reports. 40(7)
Embryonic stem cells (ESCs) can adopt lineage-specific gene-expression programs by stepwise exposure to defined factors, resulting in the generation of functional cell types. Bulk and single-cell-based assays were employed to catalog gene expression,
Autor:
Mamduh Khateb, Jelena Perovanovic, Kyung Dae Ko, Kan Jiang, Xuesong Feng, Natalia Acevedo-Luna, Jérome Chal, Veronica Ciuffoli, Pavol Genzor, James Simone, Astrid D. Haase, Olivier Pourquié, Stefania Dell’Orso, Vittorio Sartorelli
SUMMARYESCs can adopt lineage-specific gene expression programs by stepwise exposure to defined factors, resulting in the generation of functional cell types. Bulk and single cell-based assays were employed to catalogue gene expression, histone modif
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b4796d011f2c0d85845e2d15c37d03a7
https://doi.org/10.1101/2022.03.29.486247
https://doi.org/10.1101/2022.03.29.486247
Autor:
Ben-Zion Levi, Mamduh Khateb, Lior Gepstein, Nitsan Fourier, Ofer Barnea-Yizhar, Aviva Azriel, Hansjörg Hauser, Manabu Nakayama, Sigal Ram, Ulfert Rand, Ekaterina Kovalev
Publikováno v:
PLoS ONE
PLoS ONE, Vol 11, Iss 6, p e0156812 (2016)
PLoS ONE, Vol 11, Iss 6, p e0156812 (2016)
Interferon Regulatory Factor-8 (IRF-8) serves as a key factor in the hierarchical differentiation towards monocyte/dendritic cell lineages. While much insight has been accumulated into the mechanisms essential for its hematopoietic specific expressio
Autor:
Martin Ruthardt, Jamal Mahajna, Anna Metodieva, Afsar Ali Mian, Mamduh Khateb, Nili Ruimi, Yousef Najajreh, Hazem Khamisie
Publikováno v:
BMC Cancer, Vol 12, Iss 1, p 563 (2012)
BMC Cancer
BMC Cancer
Background Philadelphia positive leukemias are characterized by the presence of Bcr-Abl fusion protein which exhibits an abnormal kinase activity. Selective Abl kinase inhibitors have been successfully established for the treatment of Ph (+) leukemia
Publikováno v:
Clinical Cancer Research. 18:B57-B57
Chronic myeloid leukemia (CML) is characterized by the presence of p210Bcr-Abl which exhibits an abnormal kinase activity. Selective Abl kinase inhibitors (AKIs) have been successfully established for the treatment of CML. Despite high rates of clini
Autor:
Anna Metodieva, Jamal Mahajna, Yousef Najajreh, Nili Ruimi, Mamduh Khateb, Susanne Badura, Afsar Ali Mian, Oliver G. Ottmann, Martin Ruthardt
Publikováno v:
BMC Cancer
BMC Cancer, Vol 12, Iss 1, p 411 (2012)
BMC Cancer, Vol 12, Iss 1, p 411 (2012)
Background Chronic myelogenous leukemia (CML) and Philadelphia chromosome-positive (Ph+) acute lymphatic leukemia (Ph + ALL) are caused by the t(9;22), which fuses BCR to ABL resulting in deregulated ABL-tyrosine kinase activity. The constitutively a