Zobrazeno 1 - 10
of 33
pro vyhledávání: '"Mamdouh Sibai"'
Autor:
Ryan F. Relich, Kayla Van Benten, Guang-Sheng Lei, Christopher M. Robinson, Mariel Carozza, Malaya K. Sahoo, ChunHong Huang, Daniel Solis, Mamdouh Sibai, Christopher A. Myers, Cynthia Sikorski, Caroline Balagot, David Yang, Benjamin A. Pinsky, Michael J. Loeffelholz
Publikováno v:
Microbiology Spectrum, Vol 12, Iss 4 (2024)
ABSTRACTDespite having high analytical sensitivities and specificities, qualitative SARS-CoV-2 nucleic acid amplification tests (NAATs) cannot distinguish infectious from non-infectious virus in clinical samples. In this study, we determined the high
Externí odkaz:
https://doaj.org/article/df896f4efe91451fb637a3075dd94215
Autor:
Sirle Saul, Marwah Karim, Luca Ghita, Pei-Tzu Huang, Winston Chiu, Verónica Durán, Chieh-Wen Lo, Sathish Kumar, Nishank Bhalla, Pieter Leyssen, Farhang Alem, Niloufar A. Boghdeh, Do H.N. Tran, Courtney A. Cohen, Jacquelyn A. Brown, Kathleen E. Huie, Courtney Tindle, Mamdouh Sibai, Chengjin Ye, Ahmed Magdy Khalil, Kevin Chiem, Luis Martinez-Sobrido, John M. Dye, Benjamin A. Pinsky, Pradipta Ghosh, Soumita Das, David E. Solow-Cordero, Jing Jin, John P. Wikswo, Dirk Jochmans, Johan Neyts, Steven De Jonghe, Aarthi Narayanan, Shirit Einav
Publikováno v:
The Journal of Clinical Investigation, Vol 133, Iss 19 (2023)
Targeting host factors exploited by multiple viruses could offer broad-spectrum solutions for pandemic preparedness. Seventeen candidates targeting diverse functions emerged in a screen of 4,413 compounds for SARS-CoV-2 inhibitors. We demonstrated th
Externí odkaz:
https://doaj.org/article/9cc9d935abdc4025aa6c81ab75a6d932
Autor:
Anthony T. Le, Manhong Wu, Afraz Khan, Nicholas Phillips, Pranav Rajpurkar, Megan Garland, Kayla Magid, Mamdouh Sibai, ChunHong Huang, Malaya K. Sahoo, Raffick Bowen, Tina M. Cowan, Benjamin A. Pinsky, Catherine A. Hogan
Publikováno v:
Frontiers in Microbiology, Vol 13 (2023)
IntroductionThe routine clinical diagnosis of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is largely restricted to real-time reverse transcription quantitative PCR (RT-qPCR), and tests that detect SARS-CoV-2 nucleocapsid antigen. Giv
Externí odkaz:
https://doaj.org/article/55ea6145256d403298cf77d7ec3cfb0b
Autor:
Yiran E. Liu, Sirle Saul, Aditya Manohar Rao, Makeda Lucretia Robinson, Olga Lucia Agudelo Rojas, Ana Maria Sanz, Michelle Verghese, Daniel Solis, Mamdouh Sibai, Chun Hong Huang, Malaya Kumar Sahoo, Rosa Margarita Gelvez, Nathalia Bueno, Maria Isabel Estupiñan Cardenas, Luis Angel Villar Centeno, Elsa Marina Rojas Garrido, Fernando Rosso, Michele Donato, Benjamin A. Pinsky, Shirit Einav, Purvesh Khatri
Publikováno v:
Genome Medicine, Vol 14, Iss 1, Pp 1-15 (2022)
Abstract Background Each year 3–6 million people develop life-threatening severe dengue (SD). Clinical warning signs for SD manifest late in the disease course and are nonspecific, leading to missed cases and excess hospital burden. Better SD progn
Externí odkaz:
https://doaj.org/article/793e01a463394919ad34b1afb12b340e
Autor:
Seth A. Hoffman, Cristina Costales, Malaya K. Sahoo, Srikanth Palanisamy, Fumiko Yamamoto, ChunHong Huang, Michelle Verghese, Daniel A. Solis, Mamdouh Sibai, Aruna Subramanian, Lucy S. Tompkins, Philip Grant, Robert W. Shafer, Benjamin A. Pinsky
Publikováno v:
Emerging Infectious Diseases, Vol 27, Iss 10, Pp 2720-2723 (2021)
We report persistent severe acute respiratory syndrome coronavirus 2 infection in a patient with HIV/AIDS; the virus developed spike N terminal domain and receptor binding domain neutralization resistance mutations. Our findings suggest that immunoco
Externí odkaz:
https://doaj.org/article/68f1f33cf89a40c099c342a2b7541032
Autor:
ChunHong Huang, Malaya K. Sahoo, Michelle Verghese, Mamdouh Sibai, Daniel Solis, Kenji O. Mfuh, Jason Kurzer, Catherine A. Hogan, Thuy A. Doan, Benjamin A. Pinsky
Publikováno v:
Microbiology Spectrum, Vol 10, Iss 3 (2022)
Externí odkaz:
https://doaj.org/article/e19c917d20004605a52b31325269983c
Autor:
Aslam Khan, Caroline Ichura, Hannah Wang, Izabela Rezende, Malaya K. Sahoo, ChunHong Huang, Daniel Solis, Mamdouh Sibai, Fumiko Yamamoto, Sindiso Nyathi, Bethel Bayrau, Benjamin A. Pinsky, A. Desiree LaBeaud
Publikováno v:
Frontiers in Medicine, Vol 9 (2022)
Since March 2020, SARS-CoV-2 has plagued the world with COVID-19 and individuals of all ages have experienced varying symptoms of disease. Older adults were experiencing more severe disease compared to children and were prioritized by vaccination eff
Externí odkaz:
https://doaj.org/article/e1403c527baf4e45a05b495fb5aef28a
Autor:
Catherine A. Hogan, ChunHong Huang, Malaya K. Sahoo, Hannah Wang, Becky Jiang, Mamdouh Sibai, Marisa Holubar, Roshni Mathew, James Zehnder, Benjamin A. Pinsky
Publikováno v:
Emerging Infectious Diseases, Vol 27, Iss 2, Pp 632-635 (2021)
We developed an assay that detects minus-strand RNA as a surrogate for actively replicating severe acute respiratory syndrome coronavirus 2. We detected minus-strand RNA in 41 persons with coronavirus disease up to 30 days after symptom onset. This a
Externí odkaz:
https://doaj.org/article/59ae6e0af5584b699813da7ccec74505
Autor:
Hannah Wang, Catherine A. Hogan, Jacob A. Miller, Malaya K. Sahoo, ChunHong Huang, Kenji O. Mfuh, Mamdouh Sibai, James Zehnder, Brendan Hickey, Nasa Sinnott-Armstrong, Benjamin A. Pinsky
Publikováno v:
Emerging Infectious Diseases, Vol 27, Iss 1, Pp 92-103 (2021)
Pooled nucleic acid amplification tests for severe acute respiratory syndrome coronavirus 2 could increase availability of testing at decreased cost. However, the effect of dilution on analytical sensitivity through sample pooling has not been well c
Externí odkaz:
https://doaj.org/article/d6fd914ed3e14445965014ad4a3d94f3
Autor:
Daniel Solis, Bryan A. Stevens, James L. Zehnder, Scott D. Boyd, Hannah Wang, Malaya K. Sahoo, Benjamin A. Pinsky, Mamdouh Sibai, Fumiko Yamamoto, Katharina Röltgen, Michelle Verghese, Catherine A. Hogan, ChunHong Huang
Publikováno v:
Clinical Chemistry
Background Detection of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nucleocapsid antigen in blood has been described, but the diagnostic and prognostic role of antigenemia is not well understood. This study aimed to determine the fre