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Mambalgin-3 potentiates human acid-sensing ion channel 1b under mild to moderate acidosis: Implications as an analgesic lead

Autor: Elena Budusan, Lachlan D. Rash, Ben Cristofori-Armstrong

Publikováno v: Proceedings of the National Academy of Sciences of the United States of America

Acid-sensing ion channels (ASICs) are expressed in the nervous system, activated by acidosis, and implicated in pain pathways. Mambalgins are peptide inhibitors of ASIC1 and analgesic in rodents via inhibition of centrally expressed ASIC1a and periph

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::44d321907e0c438dc5e01667939ac42e
https://pubmed.ncbi.nlm.nih.gov/33602819

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Cryo-EM structure of the ASIC1a–mambalgin-1 complex reveals that the peptide toxin mambalgin-1 inhibits acid-sensing ion channels through an unusual allosteric effect

Autor: Xiaobin Xue, Qian Qu, Maojun Yang, Changlin Tian, Xueming Li, You Yu, Man Pan, Longhua Zhang, Xiaorun Li, Lei Liu, Siyu Li, Demeng Sun, Ming Wen

Publikováno v: Cell Discovery, Vol 4, Iss 1, Pp 1-11 (2018)
Cell Discovery

Acid-sensing ion channels (ASICs) are neuronal voltage-independent Na+ channels that are activated by extracellular acidification. ASICs play essential roles in a wide range of physiological processes, including sodium homeostasis, synaptic plasticit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0050a2b454cedd84c243286865b9e73c
http://link.springer.com/article/10.1038/s41421-018-0026-1

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Mambalgins, Snake Peptides Against Inflammatory and Neuropathic Pain Through Inhibition of ASIC Channels

Autor: Miguel Salinas, Pascal Kessler, Dominique Douguet, Gilles Mourier, Thomas Besson, Abdelkrim Alloui, Sylvie Diochot, Anne Baron, Valérie Friend, Enrico A. Stura, Denis Servent, Alain Eschalier, Eric Lingueglia

Publikováno v: Toxicon
Toxicon, Elsevier, 2018, 149, pp.93. ⟨10.1016/j.toxicon.2017.12.026⟩
SFET
SFET, 2016, Paris, France. pp.93, ⟨10.1016/j.toxicon.2017.12.026⟩
SFET Société Française d'Etude des Toxines
SFET Société Française d'Etude des Toxines, Dec 2016, Paris, France. pp.93, ⟨10.1016/j.toxicon.2017.12.026⟩
Toxicon, 2018, 149, pp.93. ⟨10.1016/j.toxicon.2017.12.026⟩

International audience; Mambalgins are 57-amino acid peptides isolated from mamba venom. They produce potent analgesic effects in mice against inflammatory pain upon central intrathecal (i.t.), and peripheral local (i.pl.) injections, through inhibit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8f3189f7bb9b683a17edca0e238c338
https://hal.archives-ouvertes.fr/hal-02368770

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Research Strategies for Pain in Lumbar Radiculopathy Focusing on Acid-Sensing Ion Channels and Their Toxins

Autor: Jiann Her Lin, Yung Hsiao Chiang, Chih-Cheng Chen

Publikováno v: Current Topics in Medicinal Chemistry. 15:617-630

In lumbar radiculopathy, the dorsal root or dorsal root ganglia (DRG) are compressed or affected by herniated discs or degenerative spinal canal stenosis. The disease is multi-factorial and involves almost all types of pain, such as ischemic, inflamm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9136e673baa0ead29ee7cf048ee05a2d
https://doi.org/10.2174/1568026615666150217112652

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Medical Science Turns Deadly Substances into Life Saving Ones: Snake Venom as a Treatment Option

Autor: Nameera Ahmad, Bushra Rubab, Somia Gul, Urooba Iqbal

Publikováno v: OALib. :1-9

Background: The word “venom” has always been taken as the synonym for poison or a vile liquid with catastrophic effects. Out of several different venomous creatures, snakes have perked special interest of scientists and researchers in this matter

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::811fb14a0a4a803f03b94932d3c0dc66
https://doi.org/10.4236/oalib.1101323

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Mambalgins, the Venom-origin Peptides as a Potentially Novel Group of Analgesics: Mini Review

Autor: Maksymilian A. Brzezicki, Przemysław Zakowicz

Publikováno v: CNSneurological disorders drug targets. 17(2)

Background: Despite a wide variety of current analgesia regimens, chronic pain is an incredibly difficult condition to treat. Its pathophysiology, initiation, development and course involve a range of different receptors and transmitters. The acid-se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8b961ce32569c74e8bdf373594b311e5
https://pubmed.ncbi.nlm.nih.gov/29268691

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Analgesic effects of mambalgin peptide inhibitors of acid-sensing ion channels in inflammatory and neuropathic pain

Autor: Alain Eschalier, Sylvie Diochot, Abdelkrim Alloui, Mélodie Dauvois, Youssef Aissouni, Anne Baron, Eric Lingueglia, Valérie Friend, Précillia Rodrigues

Publikováno v: PAIN
PAIN, Elsevier, 2016, 157 (3), pp.552-559. ⟨10.1097/j.pain.0000000000000397⟩
PAIN, 2016, 157 (3), pp.552-559. ⟨10.1097/j.pain.0000000000000397⟩
Pain
Pain, 2016, 157 (3), pp.552-559. ⟨10.1097/j.pain.0000000000000397⟩

International audience; Mambalgins are 57-amino acid peptides isolated from snake venom that evoke naloxone-resistant analgesia after local (intraplantar) and central (intrathecal) injections through inhibition of particular subtypes of acid-sensing

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b9ac5873edda37635bb95613dbaed09a
https://hal.archives-ouvertes.fr/hal-02267118

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Binding Site and Inhibitory Mechanism of the Mambalgin-2 Pain-relieving Peptide on Acid-sensing Ion Channel 1a*

Autor: Miguel Salinas, Dominique Douguet, Quentin Delettre, Sonia Boulakirba, Thomas Besson, Sylvie Diochot, Eric Lingueglia

Publikováno v: Journal of Biological Chemistry
Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2014, 289 (19), pp.13363-13373. ⟨10.1074/jbc.M114.561076⟩

Acid-sensing ion channels (ASICs) are neuronal proton-gated cation channels associated with nociception, fear, depression, seizure, and neuronal degeneration, suggesting roles in pain and neurological and psychiatric disorders. We have recently disco

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::344512f3bfe8d2eaf399719e6d597362
https://europepmc.org/articles/PMC4036345/

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Venom toxins in the exploration of molecular, physiological and pathophysiological functions of acid-sensing ion channels

Autor: Miguel Salinas, Anne Baron, Sylvie Diochot, Jacques Noël, Emmanuel Deval, Eric Lingueglia

Publikováno v: Toxicon
Toxicon, Elsevier, 2013, 75, pp.187-204. ⟨10.1016/j.toxicon.2013.04.008⟩

International audience; Acid-sensing ion channels (ASICs) are voltage-independent proton-gated cation channels that are largely expressed in the nervous system as well as in some non-neuronal tissues. In rodents, six different isoforms (ASIC1a, 1b, 2

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c4cd758afaecfd45fd633f535aa5ba2d
https://hal.archives-ouvertes.fr/hal-02268192

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