Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Malyn May A Valenzuela"'
Autor:
Salma Khan, Jessica M S Jutzy, Malyn May A Valenzuela, David Turay, Jonathan R Aspe, Arjun Ashok, Saied Mirshahidi, Dan Mercola, Michael B Lilly, Nathan R Wall
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46737 (2012)
Survivin is expressed in prostate cancer (PCa), and its downregulation sensitizes PCa cells to chemotherapeutic agents in vitro and in vivo. Small membrane-bound vesicles called exosomes, secreted from the endosomal membrane compartment, contain RNA
Externí odkaz:
https://doaj.org/article/40116a345e2c4f1f863f2101d3667b89
Autor:
Eileen Brantley, Willie Davis, George Huang, Leah K. Rowland, Helen Jacobs, Simone Badal, David J. Gangemi, Greg Raner, Sheena Francis, Rupika Delgoda, Ashley Quitugua, Malyn May Asuncion Valenzuela, Pallavi Vendantam, Jonathan V. Wooten, Petreena Campbell, Louisa Amis, Dain Zylstra, Tzuen-Rong J. Tzeng
Publikováno v:
Journal of Applied Toxicology. 37:873-883
Quassinoids often exhibit antioxidant and antiproliferative activity. Emerging evidence suggests that these natural metabolites also display chemopreventive actions. In this study, we investigated the potential for the quassinoid glaucarubulone gluco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::969b6a7b634d955f3aab79cc0bccc025
https://doi.org/10.1002/jat.3436
https://doi.org/10.1002/jat.3436
Autor:
Ulysses Sigaran, Amber Gonda, Nathan R. Wall, Heather R. Ferguson Bennit, Malyn May Asuncion Valenzuela, TessaRae Stiff, Carlos J. Diaz Osterman, Salma Khan, Ron B. Moyron
Publikováno v:
Pancreas. 45:101-109
Objectives The inhibitor of apoptosis (IAP) proteins are critical modulators of chemotherapeutic resistance in various cancers. To address the alarming emergence of chemotherapeutic resistance in pancreatic cancer, we investigated the efficacy of the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::810d37385dafe38f0efb1ea9cb3d48a5
https://doi.org/10.1097/mpa.0000000000000411
https://doi.org/10.1097/mpa.0000000000000411
Autor:
Nathan R. Wall, Amber Gonda, Heather R. Ferguson Bennit, Salma Khan, Malyn May Asuncion Valenzuela, Abby Hibma, Carlos J. Diaz Osterman
Exosomes are endosomal-derived nanovesicles released by normal and tumor cells which have been shown to transfer functionally active protein, lipids, mRNAs and miRNAs between cells. Varying in molecular profiles, biological roles, functional roles an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96f1464eca05b8b627ce611e83636964
https://europepmc.org/articles/PMC4542824/
https://europepmc.org/articles/PMC4542824/
Publikováno v:
Chemotherapy
Pancreatic cancer is a deadly and aggressive disease. Less than 1% of diagnosed patients survive 5 years with an average survival time of only 4-8 months. The only option for metastatic pancreatic cancer is chemotherapy where only the antimetabolites
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0dfbe56331aa9be3aa209c9f50d7e9d8
http://europepmc.org/articles/PMC4494102
http://europepmc.org/articles/PMC4494102
Autor:
Salma Khan, Heather R. Ferguson Bennit, Carlos J. Diaz Osterman, Malyn May Asuncion Valenzuela, Nathan R. Wall
Publikováno v:
Cancer Research. 74:3207-3207
Background Pancreatic cancer has among the highest mortality rates compared to other cancer types, with 94% of patients dying within five years of diagnosis. Contributing to the high mortality rate, patients with pancreatic cancer do not present sign
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::59c3264a1cebc1e0491411b011020813
https://doi.org/10.1158/1538-7445.am2014-3207
https://doi.org/10.1158/1538-7445.am2014-3207
Autor:
Carlos J. Diaz Osterman, Malyn May Asuncion Valenzuela, Carlos A. Casiano, Heather R. Ferguson Bennit, Salma Khan, Nathan R. Wall
Publikováno v:
Cancer Research. 74:4856-4856
We have shown that Survivin is exported out of the cancer cell via exosomes despite its lack of a secretory signaling peptide. However, the mechanism of Survivin exosomal loading is not yet known. Exosomal protein sorting can be endosomal sorting com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cb8898911d7c7645ad304fb345cad1de
https://doi.org/10.1158/1538-7445.am2014-4856
https://doi.org/10.1158/1538-7445.am2014-4856
Autor:
Jonathan W. Neidigh, Malyn May Asuncion Valenzuela, Jonathan R. Aspe, Imilce V. Castro, Nathan R. Wall
Publikováno v:
Therapy.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::1bf499d17c481fc20773148cde27c858
https://doi.org/10.1158/1538-7445.panca2012-a22
https://doi.org/10.1158/1538-7445.panca2012-a22
Autor:
Kimberly J. Payne, Nathan R. Wall, Malyn May Asuncion-Valenzuela, Salma Khan, Jessica M. S. Jutzy, Terry-Ann Milford
Publikováno v:
Cancer microenvironment : official journal of the International Cancer Microenvironment Society. 6(1)
Clinical studies of T cell profiles from cancer patients have shown a skewing toward a type-2 T cell response with decreased cytotoxic T cell function. However, the primary cause of this shift remains unknown. Here we show that tumor-released Survivi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83e2ca90669b20972f698b19f6c1eb53
https://pubmed.ncbi.nlm.nih.gov/22322461
https://pubmed.ncbi.nlm.nih.gov/22322461
Autor:
David Turay, Carlos J. Diaz Osterman, Heather R. Ferguson Bennit, Malyn May Asuncion Valenzuela, Arjun Ashok, Ron B. Moyron, Nathan R. Wall, Grace E. Esebanmen, Salma Khan
Publikováno v:
Biologics : Targets & Therapy
Survivin is one of the most important members of the inhibitors of apoptosis protein family, as it is expressed in most human cancers but is absent in normal, differentiated tissues. Lending to its importance, survivin has proven associations with ap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9151b2c67129654afb29748f740955ad
https://doi.org/10.2147/btt.s83864
https://doi.org/10.2147/btt.s83864