Zobrazeno 1 - 10
of 32
pro vyhledávání: '"Malwina Michalak"'
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 12, p 6414 (2022)
Galectin-4 (Gal4) has been suggested to function as a tumor suppressor in colorectal cancer (CRC). In order to systematically explore its function in CRC, we established a CRC cell line where Gal4 expression can be regulated via the doxycycline (dox)
Externí odkaz:
https://doaj.org/article/6404d1f27f8a4e18b8fa984dc85f0996
Autor:
Malwina Michalak, Martin Simon Kalteis, Aysel Ahadova, Matthias Kloor, Mark Kriegsmann, Katharina Kriegsmann, Uwe Warnken, Dominic Helm, Jürgen Kopitz
Publikováno v:
Molecules, Vol 26, Iss 12, p 3564 (2021)
Glycosylation is the most prevalent and varied form of post-translational protein modifications. Protein glycosylation regulates multiple cellular functions, including protein folding, cell adhesion, molecular trafficking and clearance, receptor acti
Externí odkaz:
https://doaj.org/article/3905173813f440df958d63df45b737ae
Autor:
Fabia Fricke, Jennifer Lee, Malwina Michalak, Uwe Warnken, Ingrid Hausser, Meggy Suarez-Carmona, Niels Halama, Martina Schnölzer, Jürgen Kopitz, Johannes Gebert
Publikováno v:
Cell Communication and Signaling, Vol 15, Iss 1, Pp 1-14 (2017)
Abstract Background Colorectal cancers (CRCs) that lack DNA mismatch repair function exhibit the microsatellite unstable (MSI) phenotype and are characterized by the accumulation of frameshift mutations at short repetitive DNA sequences (microsatelli
Externí odkaz:
https://doaj.org/article/061c11ab991948279db53d1ae5c7f245
Autor:
Malwina Michalak, Eva-Maria Katzenmaier, Nina Roeckel, Stefan M. Woerner, Vera Fuchs, Uwe Warnken, Yan P. Yuan, Peer Bork, Gabriele Neu-Yilik, Andreas Kulozik, Magnus von Knebel Doeberitz, Matthias Kloor, Jürgen Kopitz, Johannes Gebert
Publikováno v:
International Journal of Molecular Sciences, Vol 21, Iss 15, p 5234 (2020)
DNA mismatch repair-deficient colorectal cancers (CRCs) accumulate numerous frameshift mutations at repetitive sequences recognized as microsatellite instability (MSI). When coding mononucleotide repeats (cMNRs) are affected, tumors accumulate frames
Externí odkaz:
https://doaj.org/article/00967a25e1b543a1a260e64eabec6fbf
Autor:
Fabia Fricke, Malwina Michalak, Uwe Warnken, Ingrid Hausser, Martina Schnölzer, Jürgen Kopitz, Johannes Gebert
Publikováno v:
International Journal of Molecular Sciences, Vol 20, Iss 17, p 4162 (2019)
Microsatellite unstable (MSI) colorectal cancers (CRCs) are characterized by mutational inactivation of Transforming Growth Factor Beta Receptor Type 2 (TGFBR2). TGFBR2-deficient CRCs present altered target gene and protein expression. Such cellular
Externí odkaz:
https://doaj.org/article/77f99c9c0fce450c9b6fcc0fdc16ca69
Autor:
Anna-Kristin Ludwig, Malwina Michalak, Nadya Shilova, Sabine André, Herbert Kaltner, Nicolai V. Bovin, Jürgen Kopitz, Hans-Joachim Gabius
Publikováno v:
Molecules, Vol 22, Iss 9, p 1572 (2017)
Tissue lectins are emerging (patho)physiological effectors with broad significance. The capacity of adhesion/growth-regulatory galectins to form functional complexes with distinct cellular glycoconjugates is based on molecular selection of matching p
Externí odkaz:
https://doaj.org/article/3453bb29b45f44bd83fc75f50e196c5e
Autor:
Carsten Jers, Malwina Michalak, Dorte M Larsen, Kasper P Kepp, Haiying Li, Yao Guo, Finn Kirpekar, Anne S Meyer, Jørn D Mikkelsen
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e83902 (2014)
This paper reports rational engineering of Trypanosoma rangeli sialidase to develop an effective enzyme for a potentially important type of reactivity: production of sialylated prebiotic glycans. The Trypanosoma cruzi trans-sialidase and the homologo
Externí odkaz:
https://doaj.org/article/7ce5c01b05ce4c2b82b60c94e2281430
Autor:
Forrest G FitzGerald, Jürgen Kopitz, Hans-Joachim Gabius, Malwina Michalak, Herbert Kaltner, Donella Beckwith, Anna-Kristin Ludwig, Elizabeth R Mercer, Maria C. Rodriguez Benavente, Mare Cudic
Publikováno v:
Biochemistry. 60:547-558
Human macrophage galactose-type lectin (hMGL, HML, CD301, CLEC10A), a C-type lectin expressed by dendritic cells and macrophages, is a receptor for N-acetylgalactosamine α-linked to serine/threonine residues (Tn antigen, CD175) and its α2,6-sialyla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5bc981b2ac478f60608b4c053f452d4b
https://doi.org/10.1021/acs.biochem.0c00942
https://doi.org/10.1021/acs.biochem.0c00942
Autor:
Irina V. Nesmelova, Herbert Kaltner, Hans-Joachim Gabius, Aurelio J. Dregni, Vladimir A. Daragan, Malwina Michalak, Jürgen Kopitz, Michelle C. Miller, Hans Ippel, Kevin H. Mayo
Publikováno v:
Biochemical Journal
Biochemical Journal, 477(17), 3147-3165. Portland Press Ltd.
Biochemical Journal, 477(17), 3147-3165. Portland Press Ltd.
Human galectin-7 (Gal-7; also termed p53-induced gene 1 product) is a multifunctional effector by productive pairing with distinct glycoconjugates and protein counter-receptors in the cytoplasm and nucleus, as well as on the cell surface. Its structu
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::38b3fcde4f0b1b441da0ca8b8c21ae2f
https://doi.org/10.1042/bcj20200499
https://doi.org/10.1042/bcj20200499
Autor:
Hans-Joachim Gabius, Forrest G FitzGerald, Mark Kriegsmann, Paul V. Murphy, Malwina Michalak, Tanja J Kutzner, Anna-Kristin Ludwig, Mare Cudic, Donella Beckwith, Joachim C. Manning, Gabriel García Caballero, Herbert Kaltner, Adele Gabba, Jürgen Kopitz
Publikováno v:
Histochemistry and cell biology. 156(3)
Wild-type lectins have distinct types of modular design. As a step to explain the physiological importance of their special status, hypothesis-driven protein engineering is used to generate variants. Concerning adhesion/growth-regulatory galectins, n
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b766078e5b9df341c7c3d19f9197866f
https://pubmed.ncbi.nlm.nih.gov/34152508
https://pubmed.ncbi.nlm.nih.gov/34152508