Nephrin Loss Can Be Used to Predict Remission and Long-term Renal Outcome in Patients With Minimal Change Disease

Autor: Nina A. van de Lest, Malu Zandbergen, Daphne H.T. IJpelaar, Ron Wolterbeek, Jan A. Bruijn, Ingeborg M. Bajema, Marion Scharpfenecker

Publikováno v: Kidney International Reports, Vol 3, Iss 1, Pp 168-177 (2018)

Minimal change disease is a common cause of nephrotic syndrome. In general, patients with minimal change disease respond to corticosteroids and have excellent long-term renal survival. However, some patients have less favorable outcome. These patient

Externí odkaz: https://doaj.org/article/297bf15bf01d4e12921fc025f55d1d7a

Early systemic microvascular damage in pigs with atherogenic diabetes mellitus coincides with renal angiopoietin dysbalance.

Autor: Meriem Khairoun, Mieke van den Heuvel, Bernard M van den Berg, Oana Sorop, Rients de Boer, Nienke S van Ditzhuijzen, Ingeborg M Bajema, Hans J Baelde, Malu Zandbergen, Dirk J Duncker, Ton J Rabelink, Marlies E J Reinders, Wim J van der Giessen, Joris I Rotmans

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0121555 (2015)

Diabetes mellitus (DM) is associated with a range of microvascular complications including diabetic nephropathy (DN). Microvascular abnormalities in the kidneys are common histopathologic findings in DN, which represent one manifestation of ongoing s

Externí odkaz: https://doaj.org/article/b2d21dc5d4e546dcb903327ef36f5aaf

Endothelial Endothelin Receptor A Expression Is Associated With Podocyte Injury and Oxidative Stress in Patients With Focal Segmental Glomerulosclerosis

Autor: Marion Scharpfenecker, Aimée E. Bakker, Malu Zandbergen, Sharon A.C. Heemskerk, Kyra L. Dijkstra, Nina A. van de Lest, Ron Wolterbeek, Jan A. Bruijn

Publikováno v: Kidney International Reports

Introduction The podocyte is thought to be the mainly affected cell type in focal segmental glomerulosclerosis (FSGS). However, recent studies have also indicated a role for glomerular endothelial cells and podocyte−endothelial crosstalk in FSGS de

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::96c98a77d00cd8487b902ea7a8ef2cf6
https://doi.org/10.1016/j.ekir.2021.04.013

Endoglin promotes myofibroblast differentiation and extracellular matrix production in diabetic nephropathy

Autor: Tessa Gerrits, Jan A. Bruijn, Hans J. Baelde, Marion Scharpfenecker, Malu Zandbergen, Ron Wolterbeek

Publikováno v: International Journal of Molecular Sciences
Volume 21
Issue 20
International Journal of Molecular Sciences, Vol 21, Iss 7713, p 7713 (2020)
International Journal of Molecular Sciences, 21(20). MDPI

Diabetic nephropathy (DN) is a complication of diabetes mellitus that can lead to proteinuria and a progressive decline in renal function. Endoglin, a co-receptor of TGF-&beta
is known primarily for regulating endothelial cell function
howe

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a54e5efc6206e2d3f02a35b7b2fe41eb
https://hdl.handle.net/1887/3185171

Endoglin Mediates Vascular Endothelial Growth Factor-A-Induced Endothelial Cell Activation by Regulating Akt Signaling

Autor: Pascal Bus, Sharon A.C. Heemskerk, Malu Zandbergen, Jan A. Bruijn, Tessa Gerrits, Ron Wolterbeek, Hans J. Baelde, Marion Scharpfenecker

Publikováno v: American Journal of Pathology, 188(12), 2924-2935

In diabetic nephropathy, differential expression of growth factors leads to vascular changes, including endothelial cell activation, monocyte infiltration, and inflammation. Endoglin plays an important role in endothelial function and is also associa

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cc9ef5cc663da8ed4aea41afd93dd9e7
https://hdl.handle.net/1887/95958