Selective inhibition of somatostatin-positive dentate hilar interneurons induces age-related cellular changes and cognitive dysfunction

Autor: Jinrui Lyu, Rajasekar Nagarajan, Maltesh Kambali, Muxiao Wang, Uwe Rudolph

Publikováno v: PNAS Nexus. 2

The cellular basis of age-related impairments of hippocampal function is not fully understood. In order to evaluate the role of somatostatin-positive (Sst+) interneurons in the dentate gyrus hilus in this process, we chemogenetically inhibited Sst+in

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa9451d797301d6189046dbba0ebaea8
https://doi.org/10.1093/pnasnexus/pgad134

Genetic ablation of dentate hilar somatostatin-positive GABAergic interneurons is sufficient to induce cognitive impairment

Autor: Rajasekar Nagarajan, Jinrui Lyu, Maltesh Kambali, Muxiao Wang, Connor D. Courtney, Catherine A. Christian-Hinman, Uwe Rudolph

Aging is often associated with a decline in cognitive function. A reduction in the number of somatostatin-positive (SOM+) interneurons in the dentate gyrus (DG) has been described in cognitively impaired but not in unimpaired aged rodents. However, i

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4112842ae20fc403f55aee748f6535aa
https://doi.org/10.1101/2022.11.01.514756

List of contributors

Autor: Aarti, Abhisek, Dwivedy, Abraham, Taniya Rose, Aepuru, Radhamanohar, Akin, Lucas D., Arora, Deepshikha, Ayupova, Takhmina, Bacon, Amanda K., Bhaskar, Seemesh, Bhatia, Swasti, Bhattacharjee, Jyoti, Bonyár, Attila, Cunningham, Brian T., Das, Pratyusha, Ganesh, Kalathur Mohan, Giardino, Matteo, Gu, Han, Gupta, Yashika, Hossain, Md. Amzad, Jagadeesan, Dinesh, Janner, Davide, Jayaraj, Prithi, Jeanne, N'Diaye, Jiang, Qiuran, K., Ramya, Kaarthik, J., Kambhampati, Naga Sai Visweswar, Khemtonglang, Kodchakorn, König, Tobias A.F., Kottisa, Sumala Patnaik, Krishnamoorthy, Ananthanarayanan, Lee, Hankeun, Lin, Linley Li, Lis, S. Sudha Maria, Liu, Leyang, Liu, Ning, Liu, Weinan, Maddala, Bala Gopal, Maltesh, Kambali, Mantripragada, Bharat Srimitra, Matsumi, Noriyoshi, Menon, Devanarayanan Meena Narayana, Menon, Vidya S, Min, Hyegi, Nagar, Malhar, Nayak, Sai Prasad, Pabba, Durga Prasad, Pabba, Naveen Kumar, Pandit, Deepraj, Patra, Amarshi, Punyasloka, Saibrata, Radhakrishnan, Abinaya, Ram, Nayak, Ramamurthy, Sai Sathish, Reddy, Narendra, Reddy, Roopa, Rengarajan, Balaji, Rodger, Alison, Rovina, Kobun, Roy, Subhasis, Sabyasachi, Chakrabortty, Sampatirao, Hariprasad, Sanjeevi, Carani B., Sarkar, Swagato, Satthiyaraju, Mani, Saurabh, Umrao, Shen, Zhe, Shepherd, Skye, Shivakiran Bhaktha, B.N., Srinivasan, Nagarajan, Tan, Anqi, Tawfik, Walid, Tharmaraj, Manoja, Thirumurugan, Arun, Thomas, Sabu, Tibbs, Joseph, Vedantam, Pallavi, Vedarajan, Raman, Veettil, Binesh P, Venkatesan, Koushik, Venkateswarlu, Annapureddy, Wang, Weijing, Wang, Xiaojing, Wen Xia, Felicia Ling, Wu, Wen-Ya, Wu, Zongyu, Xing, Wang, Xiong, Yanyu, Ye, Jian, Zhang, Yuqing

Publikováno v: In Nano-Engineering at Functional Interfaces for Multidisciplinary Applications 2025:xv-xviii

Thiol Oxidation by Diamide Leads to Dopaminergic Degeneration and Parkinsonism Phenotype in Mice: A Model for Parkinson's Disease

Autor: Maltesh Kambali, Vijayalakshmi Ravindranath, Ajit Ray

Publikováno v: Antioxidantsredox signaling. 25(5)

This study investigates the role of thiol homeostasis disruption in Parkinson's disease (PD) pathogenesis using a novel animal model. A single unilateral administration of the thiol oxidant, diamide (1.45 μmol) into substantia nigra (SN) of mice lea

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::903d8ac6c839781d808e9c4c3ad59fb2
https://pubmed.ncbi.nlm.nih.gov/27121974