An RNA sponge controls quorum sensing dynamics and biofilm formation in Vibrio cholerae

Autor: Michaela Huber, Anne Lippegaus, Sahar Melamed, Malte Siemers, Benjamin R. Wucher, Mona Hoyos, Carey Nadell, Gisela Storz, Kai Papenfort

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)

Small regulatory RNAs (sRNAs) often act in concert with the RNA-chaperone Hfq to regulate the expression of multiple target transcripts in bacteria. Here, the authors identify Hfq-interacting sRNAs and their targets in the pathogen Vibrio cholerae, i

Externí odkaz: https://doaj.org/article/f507f04b470841c69f90b04b2bd9656c

Conserved hydrogen-bond motifs of membrane transporters and receptors

Autor: Michalis Lazaratos, Malte Siemers, Leonid S. Brown, Ana-Nicoleta Bondar

Publikováno v: Biochimica et biophysica acta / Biomembranes 1864(6), 183896-(2022). doi:10.1016/j.bbamem.2022.183896

Membrane transporters and receptors often rely on conserved hydrogen bonds to assemble transient paths for ion transfer or long-distance conformational couplings. For transporters and receptors that use proton binding and proton transfer for function

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::287f86014b2ed1b6bf75442c3069196b
https://hdl.handle.net/2128/33759

A graph-based approach identifies dynamic H-bond communication networks in spike protein S of SARS-CoV-2

Autor: Malte Siemers, Éva Bertalan, Konstantina Karathanou, Gebhard F. X. Schertler, Krzysztof Buzar, Coral del Val, Ana-Nicoleta Bondar, Michalis Lazaratos

Publikováno v: Journal of Structural Biology
Digibug: Repositorio Institucional de la Universidad de Granada
Universidad de Granada (UGR)
Digibug. Repositorio Institucional de la Universidad de Granada
instname
Journal of Structural Biology, 212 (2)

We apply graph-based approaches to identify H-bond clusters in protein complexes. Three conformations of spike protein S have distinct H-bond clusters at key sites. Hydrogen-bond clusters could govern structural plasticity of spike protein S. Protein

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3a9002a1c2e651124f997ba4739e9f5b
http://hdl.handle.net/10481/64227

Mechanism of Inward Proton Transport in an Antarctic Microbial Rhodopsin

Autor: Hideki Kandori, Andrew Harris, Leonid S. Brown, Ethan Watt, Anh Hoang, Michalis Lazaratos, Yuji Furutani, Sahoko Tomida, Mattia Saita, Joachim Heberle, Malte Siemers, Ana-Nicoleta Bondar, Luiz Schubert

Publikováno v: The journal of physical chemistry. B. 124(24)

Although the outward-directed proton transport across biological membranes is well studied and its importance for bioenergetics is clearly understood, inward-directed light-driven proton pumping by microbial rhodopsins has remained a mystery both phy

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::083ec0d5d56f108063e213745ac7766c
https://pubmed.ncbi.nlm.nih.gov/32436389

Bridge: A Graph-Based Algorithm to Analyze Dynamic H-Bond Networks in Membrane Proteins

Autor: Michalis Lazaratos, Konstantina Karathanou, Federico Guerra, Malte Siemers, Ana-Nicoleta Bondar, Leonid S. Brown

Publikováno v: Journal of chemical theory and computation. 15(12)

Membrane proteins that function as transporters or receptors must communicate with both sides of the lipid bilayer in which they sit. This long distance communication enables transporters to move protons or other ions and small molecules across the b

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c03fed4276846018642cfb97764fb9d2
https://pubmed.ncbi.nlm.nih.gov/31652399