Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Malte Selch, Larsen"'
Publikováno v:
Clinical Pharmacology in Drug Development. 11:910-921
Tralokinumab is the first biologic therapy for moderate-to-severe atopic dermatitis (AD) that specifically neutralizes interleukin-13 activity, a key driver of AD signs and symptoms. Tralokinumab is a human immunoglobulin G4 monoclonal antibody admin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f7771c3471560152a8af8a094a90cb6e
https://doi.org/10.1002/cpdd.1113
https://doi.org/10.1002/cpdd.1113
Autor:
Juliana C. Small, Shannon M. Zintner, Malte Selch Larsen, Bo Wiinberg, Mattias Häger, Paris Margaritis, K. M. Lövgren, Maj Petersen, Mads Kjelgaard-Hansen
Publikováno v:
J Thromb Haemost
Background Prophylactic replacement therapy in hemophilia A (HA) patients does not adequately prevent bleeds and arthropathic complications. A more refined understanding of the relationship between coagulation factor VIII (FVIII) levels and bleeding
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dca5ca1628374587136c11b49a7926ac
https://doi.org/10.1111/jth.14804
https://doi.org/10.1111/jth.14804
Autor:
Mads Kreilgaard, Bo Wiinberg, Annemarie T. Kristensen, Ulrika S. H. Simonsson, Mads Kjelgaard-Hansen, Shannon M. Zintner, Malte Selch Larsen, Paris Margaritis, Rasmus Vestergaard Juul
Publikováno v:
Haemophilia. 26:164-172
Introduction Monitoring of clinical effectiveness of bypassing agents in haemophilia patients is hampered by the lack of validated laboratory assays. Thromboelastography (TEG) and rotational thromboelastometry (ROTEM) have been evaluated for predicti
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d132cbf6ea08b498f5b645dae78b48
https://doi.org/10.1111/hae.13899
https://doi.org/10.1111/hae.13899
Autor:
Frederik Rode, Malte Selch Larsen, Isabell Vargas Christensen, Mette Loftager, Hanne Mørck Nielsen, Mads Kreilgaard
Publikováno v:
Journal of Thrombosis and Haemostasis. 17:964-974
Essentials Knowledge of the interplay between FVIII and VWF pharmacokinetics (PK) is lacking. We characterized the capacity-limited PK of FVIII and VWF. The PK model described the PK of FVIII and VWF over a broad range of rFVIII doses. High-dose rFVI
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::37addb9a69689a581c675f75e8f280ae
https://doi.org/10.1111/jth.14441
https://doi.org/10.1111/jth.14441
Autor:
Ulrika S. H. Simonsson, Mads Kreilgaard, Malte Selch Larsen, Annemarie T. Kristensen, Rasmus Vestergaard Juul
Publikováno v:
European Journal of Pharmaceutical Sciences. 123:531-538
Historically, clinical trials of haemophilia with inhibitors (HwI) have been challenged by the small patient population. New approaches to clinical trial methodology and statistical modelling could potentially be used for study optimization. The aim
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fec4f3070330b7b1cc1a68bb8cc27d07
https://doi.org/10.1016/j.ejps.2018.07.056
https://doi.org/10.1016/j.ejps.2018.07.056
Autor:
Rada M. Savic, Gordon Munro, Mads Kreilgaard, René Holm, Malte Selch Larsen, Ron J. Keizer, Arne Mørk
Publikováno v:
Pharmaceutical Research. 33:1133-1143
Gabapentin displays non-linear drug disposition, which complicates dosing for optimal therapeutic effect. Thus, the current study was performed to elucidate the pharmacokinetic/pharmacodynamic (PKPD) relationship of gabapentin’s effect on mechanica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::54dcdfb40514417c9cb07d20a3f38595
https://doi.org/10.1007/s11095-016-1859-7
https://doi.org/10.1007/s11095-016-1859-7
Autor:
Malte Selch Larsen, Mads Kreilgaard, Annemarie T. Kristensen, Henrik Agersø, Rasmus Vestergaard Juul, Ulrika S. H. Simonsson, Andreas Velsing Groth, Tom Knudsen
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 115
Various experimental animal models are used in haemophilia research, however, little is known about how well the different species predict pharmacokinetic (PK) profiles in haemophilia patients. The aim of the current study was to describe the plasma
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::274d829e546a481ac15994ab9a5cc08e
https://pubmed.ncbi.nlm.nih.gov/29369801
https://pubmed.ncbi.nlm.nih.gov/29369801
Autor:
Malte Selch Larsen, Martha Kampp Nøhr, René Holm, Carsten Uhd Nielsen, Sidsel Frølund, Mats Garmer, Mads Kreilgaard
Publikováno v:
Pharmaceutical Research. 32:898-909
Gabapentin exhibits saturable absorption kinetics, however, it remains unclear which transporters that are involved in the intestinal transport of gabapentin. Thus, the aim of the current study was to explore the mechanistic influence of transporters
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::76d42ee39a36642c25acee0cdbe1cded
https://doi.org/10.1007/s11095-014-1505-1
https://doi.org/10.1007/s11095-014-1505-1