Zobrazeno 1 - 10
of 65
pro vyhledávání: '"Malte Roerden"'
Autor:
Stefani Spranger, Darrell J Irvine, Yufei Cui, Malte Roerden, Kevin Litchfield, Noora Harake, Byungji Kim, Laura Maiorino, Jonathan Dye, Andrea B Castro, Forest M White
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 12, Iss 11 (2024)
Background Intratumoral heterogeneity (ITH) and subclonal antigen expression blunt antitumor immunity and are associated with poor responses to immune-checkpoint blockade immunotherapy (ICB) in patients with cancer. The underlying mechanisms however
Externí odkaz:
https://doaj.org/article/188966450aff41ee8558bb8597cff9ab
Autor:
Ashish Goyal, Jens Bauer, Joschka Hey, Dimitris N. Papageorgiou, Ekaterina Stepanova, Michael Daskalakis, Jonas Scheid, Marissa Dubbelaar, Boris Klimovich, Dominic Schwarz, Melanie Märklin, Malte Roerden, Yu-Yu Lin, Tobias Ma, Oliver Mücke, Hans-Georg Rammensee, Michael Lübbert, Fabricio Loayza-Puch, Jeroen Krijgsveld, Juliane S. Walz, Christoph Plass
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-19 (2023)
Abstract Immunotherapies targeting cancer-specific neoantigens have revolutionized the treatment of cancer patients. Recent evidence suggests that epigenetic therapies synergize with immunotherapies, mediated by the de-repression of endogenous retrov
Externí odkaz:
https://doaj.org/article/78cbaff3798a429b8d0dd2100c9a8172
Autor:
Stefani Spranger, Darrell Irvine, Yufei Cui, Forest White, Malte Roerden, Noora Harake, Byungji Kim
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 11, Iss Suppl 1 (2023)
Externí odkaz:
https://doaj.org/article/589bda41b8ce4ef4b9f0fc9ff1a251aa
Autor:
Ashish Goyal, Jens Bauer, Joschka Hey, Dimitris Papageorgiou, Ekaterina Stepanova, Michael Daskalakis, Marissa Dubbelaar, Boris Klimovich, Melanie Maerklin, Malte Roerden, Oliver Muecke, Hans-Georg Rammensee, Fabricio Loayza-Puch, Jeroen Krijgsveld, Michael Lübbert, Juliane Walz, Christoph Plass
Publikováno v:
HemaSphere, Vol 7, p e9967378 (2023)
Externí odkaz:
https://doaj.org/article/670908b88f5045ecba92c4ca4de6b02d
Autor:
Kim Bich Nguyen, Malte Roerden, Christopher J Copeland, Coralie M Backlund, Nory G Klop-Packel, Tanaka Remba, Byungji Kim, Nishant K Singh, Michael E Birnbaum, Darrell J Irvine, Stefani Spranger
Publikováno v:
eLife, Vol 12 (2023)
Cancer immunotherapies, in particular checkpoint blockade immunotherapy (CBT), can induce control of cancer growth, with a fraction of patients experiencing durable responses. However, the majority of patients currently do not respond to CBT and the
Externí odkaz:
https://doaj.org/article/9322e2334e694187a616ac7046594ee7
Autor:
Annika Nelde, Jonas Rieth, Malte Roerden, Marissa L. Dubbelaar, Naomi Hoenisch Gravel, Jens Bauer, Reinhild Klein, Tobias Hoheisel, Hartmut Mahrhofer, Siri Göpel, Michael Bitzer, Sebastian Hörber, Andreas Peter, Jonas S. Heitmann, Juliane S. Walz
Publikováno v:
iScience, Vol 25, Iss 12, Pp 105643- (2022)
Summary: HLA-presented antigenic peptides are central components of T cell-based immunity in infectious disease. Beside HLA molecules on cell surfaces, soluble HLA molecules (sHLA) are released in the blood suggested to impact cellular immune respons
Externí odkaz:
https://doaj.org/article/7a803a7a461344a09aaf5c2888416bee
Autor:
Malte Roerden, Rainer Döffinger, Gabriela Barcenas-Morales, Stephan Forchhammer, Stefanie Döbele, Christoph P. Berg
Publikováno v:
BMC Infectious Diseases, Vol 20, Iss 1, Pp 1-5 (2020)
Abstract Background Severe and disseminated non-tuberculous mycobacterial (NTM) infections are frequently linked to a genetic predisposition but acquired defects of the interferon gamma (IFNγ) / interleukin 12 (IL-12) pathway need to be considered i
Externí odkaz:
https://doaj.org/article/e3e1b37d542a4f4585d3ff42baaba6be
Autor:
Annika Nelde, Yacine Maringer, Tatjana Bilich, Helmut R. Salih, Malte Roerden, Jonas S. Heitmann, Ana Marcu, Jens Bauer, Marian C. Neidert, Claudio Denzlinger, Gerald Illerhaus, Walter Erich Aulitzky, Hans-Georg Rammensee, Juliane S. Walz
Publikováno v:
Frontiers in Immunology, Vol 12 (2021)
Antigen-specific immunotherapies, in particular peptide vaccines, depend on the recognition of naturally presented antigens derived from mutated and unmutated gene products on human leukocyte antigens, and represent a promising low-side-effect concep
Externí odkaz:
https://doaj.org/article/fce84625805140c6b8f41a79e36f3544
Autor:
Kathrin Rothfelder, Ilona Hagelstein, Malte Roerden, Gunnar Blumenstock, Martin Hofmann, Tina Nuebling, Gundram Jung, Helmut Rainer Salih, Daniela Dörfel
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 20, Iss 11, Pp 1150-1160 (2018)
OX40 and its ligand are members of the TNF/TNF receptor superfamily, which includes various molecules influencing cellular signaling and function of both tumor and immune cells. The ability of OX40 to promote proliferation and differentiation of acti
Externí odkaz:
https://doaj.org/article/594c54acbb2946e588a1b08ae8ab196b
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
Neoantigens derive from non-synonymous somatic mutations in malignant cells. Recognition of neoantigens presented via human leukocyte antigen (HLA) molecules on the tumor cell surface by T cells holds promise to enable highly specific and effective a
Externí odkaz:
https://doaj.org/article/f2aa78ab8761426299e344ccf50d723c