Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Malte Johannes Hannich"'
A New Laboratory Workflow Integrating the Free Light Chains Kappa Quotient into Routine CSF Analysis
Autor:
Malte Johannes Hannich, Mohammed R. Abdullah, Kathrin Budde, Astrid Petersmann, Matthias Nauck, Alexander Dressel, Marie Süße
Publikováno v:
Biomolecules, Vol 12, Iss 11, p 1690 (2022)
We performed this cohort study to test whether further analysis of intrathecal inflammation can be omitted if the free light chain kappa (FLCκ) quotient is within the reference range in the corresponding quotient diagram. FLCκ concentrations were m
Externí odkaz:
https://doaj.org/article/9bf11a70768c41c28fbcd796c58c767d
Autor:
Franz Felix Konen, Malte Johannes Hannich, Philipp Schwenkenbecher, Matthias Grothe, Konrad Gag, Konstantin Fritz Jendretzky, Stefan Gingele, Kurt-Wolfram Sühs, Torsten Witte, Thomas Skripuletz, Marie Süße
Publikováno v:
Biomedicines, Vol 10, Iss 7, p 1629 (2022)
Background: The intrathecal humoral response is the characteristic diagnostic finding in the cerebrospinal fluid (CSF) analysis of patients with multiple sclerosis (MS). Although the average age of MS patients increases, little is known about the sen
Externí odkaz:
https://doaj.org/article/5dd05852654e4722b141614e3179fbeb
Autor:
Franz Felix Konen, Philipp Schwenkenbecher, Konstantin Fritz Jendretzky, Stefan Gingele, Torsten Witte, Kurt-Wolfram Sühs, Matthias Grothe, Malte Johannes Hannich, Marie Süße, Thomas Skripuletz
Publikováno v:
Brain Sciences, Vol 12, Iss 4, p 475 (2022)
Background: Oligoclonal bands represent intrathecal immunoglobulin G (IgG) synthesis and play an important role in the diagnosis of multiple sclerosis (MS). Kappa free light chains (KFLC) are increasingly recognized as an additional biomarker for int
Externí odkaz:
https://doaj.org/article/7513ce554738492a9f0a244b6b05f9cf
Autor:
Marie Süße, Franz Felix Konen, Philipp Schwenkenbecher, Kathrin Budde, Matthias Nauck, Matthias Grothe, Malte Johannes Hannich, Thomas Skripuletz
Publikováno v:
Diagnostics, Vol 12, Iss 3, p 720 (2022)
Free light chains kappa (FLCκ) in cerebrospinal fluid (CSF) are a part of the intrathecal immune response. This observational study was conducted to investigate the effects of different disease-modifying therapies (DMT) on the humoral intrathecal im
Externí odkaz:
https://doaj.org/article/d79dcbfd650f4b039620f9ca5348e92e
Autor:
Malte Johannes Hannich, Alexander Dressel, Kathrin Budde, Astrid Petersmann, Matthias Nauck, Marie Süße
Publikováno v:
Cells, Vol 10, Iss 3, p 616 (2021)
In this retrospective, monocentric cohort study, we tested if an intrathecal free light chain kappa (FLC-k) synthesis reflects not only an IgG but also IgA and IgM synthesis. We also analysed if FLC-k can help to distinguish between an inflammatory p
Externí odkaz:
https://doaj.org/article/6f0d0df5c338400d8f97f9c87062c22e
Autor:
Matthias Grothe, Christine Holbe, Matthias Nauck, Malte Johannes Hannich, Marie Süße, Alexander Dressel, Fritz Feistner
Publikováno v:
Clinica Chimica Acta. 507:205-209
Objectives Oligoclonal band (OCB) determination in cerebrospinal fluid (CSF) is the gold standard to detect intrathecal inflammation. However, there is uncertainty about the significance of one isolated band in CSF. Free light chains kappa (FLC-k) ar
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::052ae03ad0fec936d22dbc7015bdad4d
https://doi.org/10.1016/j.cca.2020.04.029
https://doi.org/10.1016/j.cca.2020.04.029
Autor:
Torsten Witte, Philipp Schwenkenbecher, Kurt-Wolfram Sühs, Matthias Grothe, Stefan Gingele, Ulrich Wurster, Franz Felix Konen, Marie Süße, Malte Johannes Hannich, Konstantin Fritz Jendretzky, Nora Möhn, Martin Stangel, Thomas Skripuletz
Publikováno v:
Journal of Central Nervous System Disease, Vol 13 (2021)
Journal of Central Nervous System Disease
Journal of Central Nervous System Disease
Background The determination of kappa free light chains (KFLC) in cerebrospinal fluid (CSF) is an upcoming biomarker for the detection of an intrathecal immunoglobulin synthesis. Since renal function impairment leads to altered serum KFLC and albumin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0523b00ebf67d84d15e70874d73733e4
https://doaj.org/article/d25c375bbaa347e4b1ca831f181a4fc6
https://doaj.org/article/d25c375bbaa347e4b1ca831f181a4fc6
Autor:
Christine Holbe, Bettina von Sarnowski, Alexander Dressel, Johanna Ruhnau, Marie Süße, Malte Johannes Hannich
Publikováno v:
Acta Neurologica Scandinavica. 140:9-16
Objectives Correct identification of inflammatory etiologies of stroke is of outmost importance as they require treatment of the underlying disease. Aim of this study was to determine the prevalence of inflammatory changes in cerebrospinal fluid (CSF
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::eae34707ddc5eed902c8a1222e067795
https://doi.org/10.1111/ane.13094
https://doi.org/10.1111/ane.13094
Autor:
Felix von Podewils, Jan Rémi, Konrad Gag, Gabriel Möddel, Adam Strzelczyk, Friedhelm C. Schmitt, Robert D. Nass, Martin S. Hirsch, Albrecht Kunze, Susanne Knake, Carlos M. Quesada, Malte Johannes Hannich, Marie Süße, Michael P. Malter, Laura Hamann
Publikováno v:
Seizure. 91
Background This observational study was done to develop a score based on clinical predictors that enables a guided decision for the necessity of cerebrospinal fluid (CSF) analysis after first unprovoked epileptic seizures and to validate this score i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f912195c335bfd9081ad3f040b3cff4f
https://pubmed.ncbi.nlm.nih.gov/34233237
https://pubmed.ncbi.nlm.nih.gov/34233237
Autor:
Matthias Nauck, Marie Süße, Maik Pietzner, Astrid Petersmann, Alexander Dressel, Stephanie Zylla, Malte Johannes Hannich
Publikováno v:
European Journal of Neurology. 25:1134-1139
Background and purpose The gold standard for detection of intrathecal immunoglobulin synthesis is the measurement of oligoclonal bands (OCB). In the diagnosis of multiple sclerosis, the kappa free light chains (KFLC) index has a similar sensitivity a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9c408bf0d6903660becd7b3674489f86
https://doi.org/10.1111/ene.13667
https://doi.org/10.1111/ene.13667