Výsledky vyhledávání - "Malte, Schutz"

Gemini: A Noninferiority Study of Saquinavir/Ritonavir Versus Lopinavir/Ritonavir as Initial HIV-1 Therapy in Adults

Autor: U. Fritz Bredeek, Dushyantha Jayaweera, Sharon Walmsley, Malte Schutz, Jihad Slim, Douglas J. Ward, Jason Brunetta, Anchalee Avihingsanon, François Raffi, Kiat Ruxrungtham, Carol Jean Guittari, Peter Larson

Publikováno v: JAIDS Journal of Acquired Immune Deficiency Syndromes. 50:367-374

Direct comparison of the efficacy and safety of different agents is needed to guide selection of optimal treatment regimens for therapy-naive HIV-1-infected patients.: Gemini was a 48-week, multicenter, open-label, noninferiority trial in treatment-n

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::873a4b98369de700e5a627acc344f8b1
https://doi.org/10.1097/qai.0b013e318198a815

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The pharmacokinetics, safety and efficacy of boosted saquinavir tablets in HIV type-1-infected pregnant women

Autor: M. E. Van Der Ende, Christoph Wyen, Malte Schutz, Clemens Richter, Martin Vogel, Petra C. Koopmans, José Moltó, Angela Colbers, J. van der Lugt, David M. Burger, Kiat Ruxrungtham, D Hawkins

Publikováno v: Antiviral Therapy, 14, 443-50
Antiviral Therapy, 14(3), 443-450. International Medical Press Ltd
Antiviral Therapy, 14, 3, pp. 443-50

Background Pregnancy affects the pharmacokinetics of most protease inhibitors. Saquinavir, when administered in a tablet formulation, has not been studied extensively in this setting. Methods A pharmacokinetic, prospective, multicentre trial of HIV t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d918d9eae23575c4c782e96f855b2a44
https://hdl.handle.net/2066/81228

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The Safety, Efficacy, and Pharmacokinetic Profile of a Switch in Antiretroviral Therapy to Saquinavir, Ritonavir, and Atazanavir Alone for 48 Weeks and a Switch in the Saquinavir Formulation

Autor: Alan Winston, Sean Emery, Kenneth M. Williams, Malte Schutz, Matthew Law, Karen MacRae, David A. Cooper, Claudette S. Satchell, Patrick W. G. Mallon

Publikováno v: Clinical Infectious Diseases. 44:1475-1483

Background. Toxicities observed with current combination antiretroviral therapy (CART) warrant a search for novel options, such as class-sparing regimens. Ritonavir-boosted double-protease inhibitor (PI)-only regimens are such an option but are prone

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::510227195ed046f3c1f60a80659a6ba5
https://doi.org/10.1086/517507

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Effect of omeprazole on the pharmacokinetics of saquinavir-500 mg formulation with ritonavir in healthy male and female volunteers

Autor: Alan Winston, Izabela Tolowinska, David Back, Anton Pozniak, Lesley Robinson, Malte Schutz, Jennifer Unsworth, Brian Gazzard, Marta Boffito, Carl Fletcher

Publikováno v: AIDS. 20:1401-1406

Introduction: Recent studies have described reduced absorption of certain protease inhibitors when administered with agents known to increase gastric pH. No clinically significant interactions between saquinavir absorption and gastric pH have previou

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5b6a97bf0b93b91ce80da403abe0987
https://doi.org/10.1097/01.aids.0000233573.41597.8a

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Synergistic Inhibition of Protease-Inhibitor-Resistant HIV type 1 by Saquinavir in Combination with Atazanavir or Lopinavir

Autor: Laurent Thibaut, Claire-Marie Thomas, Laurent Essioux, Jean-Louis Faudon, Séverine Rochas, Elisabeth Dam, Sophie Lebel-Binay, Andrew F. Hill, François Clavel, Malte Schutz

Publikováno v: Antiviral Therapy. 12:371-380

BackgroundDouble-boosted protease inhibitors (PIs) are under investigation for the treatment of patients who are unable to take nucleoside reverse transcriptase inhibitors because of cross-resistance and/or intolerance. Evidence of synergistic inhibi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::89b9c1568334fd1db00fc5603227ab50
https://doi.org/10.1177/135965350701200313

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Persistence of intracellular HIV-1 mRNA correlates with HIV-1-specific immune responses in infected subjects on stable HAART

Autor: Alan L. Landay, Malte Schutz, Joan N. Siegel, Zareefa Flener, Scott Mccallister, Keith Shults, Bruce K. Patterson

Publikováno v: AIDS. 15:1635-1641

To determine if low level, persistent, HIV-1 replication within specific immune cells contributes to HIV-1-specific immune responsiveness.We analyzed 59 HIV-1-infected subjects on stable highly active antiretroviral therapy (HAART) therapy (not inclu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f29eb77001c00da0e1c371e6131a0cbf
https://doi.org/10.1097/00002030-200109070-00005

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Use of Complementary and Alternative Therapies in HIV-Infected Patients

Autor: Joana Charkraborty, William S. Peterson, Joan Duggan, Sadik A. Khuder, Malte Schutz

Publikováno v: AIDS Patient Care and STDs. 15:159-167

The use of complementary and alternative medicine (CAM) therapies is widespread in many chronic illnesses, including human immunodeficiency virus (HIV) infection. The objective of this study was to determine the impact of increasingly effective antir

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::13570feb3a080bd4d0e055c4ab74064e
https://doi.org/10.1089/108729101750123661

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Atovaquone Compared with Dapsone for the Prevention ofPneumocystis cariniiPneumonia in Patients with HIV Infection Who Cannot Tolerate Trimethoprim, Sulfonamides, or Both

Autor: Richard Hafner, Charles van der Horst, Robert L. Murphy, Thomas M. Hooton, Henry H. Balfour, Wafaa El-Sadr, Roberta Luskin-Hawk, Thomas Kerkering, Tony W. Cheung, Teresa Yurik, Robert H.K. Eng, Malte Schutz

Publikováno v: New England Journal of Medicine. 339:1889-1895

Background Although trimethoprim–sulfamethoxazole is the drug of choice for the prevention of Pneumocystis carinii pneumonia, many patients cannot tolerate it and must switch to an alternative agent. Methods We conducted a multicenter, open-label,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::c5d004a064c3e3d9f0c10a2ea4f0ff57
https://doi.org/10.1056/nejm199812243392604

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The pharmacokinetics, safety and efficacy of boosted saquinavir tablets in HIV type-1-infected pregnant women

Autor: Jasper, van der Lugt, Angela, Colbers, Jose, Molto, David, Hawkins, Marchina, van der Ende, Martin, Vogel, Christoph, Wyen, Malte, Schutz, Peter, Koopmans, Kiat, Ruxrungtham, Clemens, Richter, David, Burger

Publikováno v: Antiviral therapy. 14(3)

Pregnancy affects the pharmacokinetics of most protease inhibitors. Saquinavir, when administered in a tablet formulation, has not been studied extensively in this setting.A pharmacokinetic, prospective, multicentre trial of HIV type-1-infected pregn

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::16826fca1cbb23a99fd13fa7ad37047b
https://pubmed.ncbi.nlm.nih.gov/19474478

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