Zobrazeno 1 - 10
of 188
pro vyhledávání: '"Malte, Buchholz"'
Autor:
Hanna Elisabeth Schneider, Lisa-Maria Schmitt, Albert Job, Brigitte Lankat-Buttgereit, Thomas Gress, Malte Buchholz, Eike Gallmeier
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 57, Iss , Pp 101038- (2024)
The ATR-CHK1 pathway plays a fundamental role in the DNA damage response and is therefore an attractive target in cancer therapy. The antitumorous effect of ATR inhibitors is at least partly caused by synthetic lethality between ATR and various DNA r
Externí odkaz:
https://doaj.org/article/d9d2994e1d8b40feb85caf545e7e1dad
Autor:
Clara Simon, Inka D Brunke, Bastian Stielow, Ignasi Forné, Anna Mary Steitz, Merle Geller, Iris Rohner, Lisa Marie Weber, Sabrina Fischer, Lea Marie Jeude, Theresa Huber, Andrea Nist, Thorsten Stiewe, Magdalena Huber, Malte Buchholz, Robert Liefke
Publikováno v:
PLoS Biology, Vol 22, Iss 8, p e3002739 (2024)
Pancreatic ductal adenocarcinoma (PDAC) poses a significant threat due to its tendency to evade early detection, frequent metastasis, and the subsequent challenges in devising effective treatments. Processes that govern epithelial-mesenchymal transit
Externí odkaz:
https://doaj.org/article/0154901bedc94acf98fd143354555040
T-bet+ B cells are activated by and control endogenous retroviruses through TLR-dependent mechanisms
Autor:
Eileen Rauch, Timm Amendt, Aleksandra Lopez Krol, Fabian B. Lang, Vincent Linse, Michelle Hohmann, Ann-Christin Keim, Susanne Kreutzer, Kevin Kawengian, Malte Buchholz, Philipp Duschner, Saskia Grauer, Barbara Schnierle, Andreas Ruhl, Ingo Burtscher, Sonja Dehnert, Chege Kuria, Alexandra Kupke, Stephanie Paul, Thomas Liehr, Marcus Lechner, Markus Schnare, Andreas Kaufmann, Magdalena Huber, Thomas H. Winkler, Stefan Bauer, Philipp Yu
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-19 (2024)
Abstract Endogenous retroviruses (ERVs) are an integral part of the mammalian genome. The role of immune control of ERVs in general is poorly defined as is their function as anti-cancer immune targets or drivers of autoimmune disease. Here, we genera
Externí odkaz:
https://doaj.org/article/614f814272ae48b086e1c7fdf428b850
Autor:
Joel Wessendorf, Michael Scheschenja, Moritz B. Bastian, Alexander M. König, Axel Pagenstecher, Frederik Helmprobst, Malte Buchholz, Marina Tatura, Jarmila Jedelská, Andreas H. Mahnken
Publikováno v:
European Radiology Experimental, Vol 7, Iss 1, Pp 1-8 (2023)
Abstract Background We evaluated the feasibility of a chick chorioallantoic membrane (CAM) tumor model for preclinical research on tumor radiofrequency ablation (RFA). Methods Fertilized chicken eggs were incubated and divided into five cohorts: RFA
Externí odkaz:
https://doaj.org/article/f4db89f287f44be18b4e01a37b79a08c
Autor:
Silke D. Werle, Nensi Ikonomi, Ludwig Lausser, Annika M. T. U. Kestler, Felix M. Weidner, Julian D. Schwab, Julia Maier, Malte Buchholz, Thomas M. Gress, Angelika M. R. Kestler, Hans A. Kestler
Publikováno v:
npj Systems Biology and Applications, Vol 9, Iss 1, Pp 1-17 (2023)
Abstract Pancreatic neuroendocrine tumors (PanNETs) are a rare tumor entity with largely unpredictable progression and increasing incidence in developed countries. Molecular pathways involved in PanNETs development are still not elucidated, and speci
Externí odkaz:
https://doaj.org/article/4ccc6dba9fcc4072b055b2958bdc1426
Autor:
Maren Stark, Marina Nicolai, Marina Tatura, Corinna U. Keber, Andreas Kaufmann, Ho‐Ryun Chung, Emily P. Slater, Christopher Heeschen, Rita T. Lawlor, Aldo Scarpa, Detlef K. Bartsch, Thomas M. Gress, Stefan Bauer, Malte Buchholz
Publikováno v:
Cancer Medicine, Vol 12, Iss 7, Pp 8542-8556 (2023)
Abstract Background Toll‐like receptors (TLRs) are gaining attention for their potential to influence tumor biology both on the level of the tumor cells as well as on the level of the surrounding inflammatory stroma. Previous studies resulted in pa
Externí odkaz:
https://doaj.org/article/d14b8a3d788f4c6caf9c5dd955d6c74f
Autor:
Malte Buchholz, Detlef Schuppan, Pietro Di Fazio, Sophia Mielke, Isabell T Böhm, Sami Matrood, Thaddeus Wissniowski
Publikováno v:
BMJ Open Gastroenterology, Vol 10, Iss 1 (2023)
Objective Stellate cells are responsible for liver and pancreas fibrosis and strictly correlate with tumourigenesis. Although their activation is reversible, an exacerbated signalling triggers chronic fibrosis. Toll-like receptors (TLRs) modulate ste
Externí odkaz:
https://doaj.org/article/7225431439834c89ba2b5e659488bcb8
Autor:
Xu Zhou, Kai Hu, Peter Bailey, Christoph Springfeld, Susanne Roth, Roma Kurilov, Benedikt Brors, Thomas Gress, Malte Buchholz, Jingyu An, Kongyuan Wei, Teresa Peccerella, Markus W. Büchler, Thilo Hackert, John P. Neoptolemos
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 11 (2023)
Externí odkaz:
https://doaj.org/article/eeec39dc7627400fb88ad3927107e6fd
Autor:
Elena Nasiri, Malte Student, Katrin Roth, Nadya Siti Utami, Magdalena Huber, Malte Buchholz, Thomas M. Gress, Christian Bauer
Publikováno v:
Cells, Vol 12, Iss 3, p 456 (2023)
In pancreatic ductal adenocarcinoma (PDAC), the infiltration of CD8+ cytotoxic T cells (CTLs) is an important factor in determining prognosis. The migration pattern and interaction behavior of intratumoral CTLs are pivotal to tumor rejection. NLRP3-d
Externí odkaz:
https://doaj.org/article/39f184cb59d640c1976c25d95e4731e2
Autor:
Xu Zhou, Kai Hu, Peter Bailey, Christoph Springfeld, Susanne Roth, Roma Kurilov, Benedikt Brors, Thomas Gress, Malte Buchholz, Jingyu An, Kongyuan Wei, Teresa Peccerella, Markus W. Büchler, Thilo Hackert, John P. Neoptolemos
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Pancreatic ductal adenocarcinoma is a highly lethal malignancy, which has now become the seventh most common cause of cancer death in the world, with the highest mortality rates in Europe and North America. In the past 30 years, there has been some p
Externí odkaz:
https://doaj.org/article/6ac554b584fe45208d4983a549229ada