MHC class II antigen presentation by intestinal epithelial cells fine-tunes bacteria-reactive CD4 T-cell responses

Autor: Heuberger, Cornelia E., Janney, Alina, Ilott, Nicholas, Bertocchi, Alice, Pott, Sebastian, Gu, Yisu, Pohin, Mathilde, Friedrich, Matthias, Mann, Elizabeth H., Pearson, Claire, Powrie, Fiona M., Pott, Johanna, Thornton, Emily, Maloy, Kevin Joseph

Publikováno v: In Mucosal Immunology June 2024 17(3):416-430

Why do intestinal epithelial cells express MHC class II?

Autor: Heuberger, Cornelia, Pott, Johanna, Maloy, Kevin Joseph

Intestinal epithelial cells (IECs) constitute the border between the vast antigen load present in the intestinal lumen and the mucosal immune compartment. Their ability to express antigen processing and presentation machinery evokes the question whet

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https://eprints.gla.ac.uk/228291/1/228291.pdf

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Why do intestinal epithelial cells express MHC class II?

Autor: Heuberger C; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.; Kennedy Institute of Rheumatology, University of Oxford, Oxford, UK., Pott J; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.; Hubrecht Organoid Technology, Utrecht, Netherlands., Maloy KJ; Sir William Dunn School of Pathology, University of Oxford, Oxford, UK.; Institute of Infection, Immunity and Inflammation, University of Glasgow, Glasgow, UK.

Publikováno v: Immunology [Immunology] 2021 Apr; Vol. 162 (4), pp. 357-367. Date of Electronic Publication: 2020 Oct 12.