Epitranscriptomic reader YTHDF2 regulates SEK1( MAP2K4 )-JNK-cJUN inflammatory signaling in astrocytes during neurotoxic stress.

Autor: Malovic E; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA., Ealy A; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., Miller C; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., Jang A; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., Hsu PJ; Department of Chemistry, University of Chicago, Chicago, IL, USA., Sarkar S; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA., Rokad D; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA., Goeser C; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA., Hartman AK; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA., Zhu A; Department of Chemistry, University of Chicago, Chicago, IL, USA., Palanisamy B; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA., Zenitsky G; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., Jin H; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., Anantharam V; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., Kanthasamy A; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA., He C; Department of Chemistry, University of Chicago, Chicago, IL, USA., Kanthasamy AG; Parkinson's Disorder Research Laboratory, Department of Biomedical Sciences, Iowa State University, Ames, IA, USA.; Isakson Center for Neurological Disease Research, University of Georgia, Athens, GA, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA, USA.; Department of Biochemistry and Molecular Biology, University of Georgia, Athens, GA, USA.

Publikováno v: IScience [iScience] 2024 Jul 31; Vol. 27 (9), pp. 110619. Date of Electronic Publication: 2024 Jul 31 (Print Publication: 2024).

Aggregation-Inhibiting scFv-Based Therapies Protect Mice against AAV1/2-Induced A53T-α-Synuclein Overexpression.

Autor: Schlichtmann BW; Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA.; Nanovaccine Institute, Ames, IA 50011, USA., Palanisamy BN; Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Malovic E; Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Nethi SK; Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA.; Nanovaccine Institute, Ames, IA 50011, USA., Padhi P; Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Hepker M; Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Wurtz J; Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., John M; Nanovaccine Institute, Ames, IA 50011, USA.; PathoVacs, Incorporated, Ames, IA 50011, USA., Ban B; Indiana Biosciences Research Institute (IBRI), Indianapolis, IN 46202, USA., Anantharam V; Nanovaccine Institute, Ames, IA 50011, USA.; PK Biosciences Corporation, Ames, IA 50011, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA., Kanthasamy AG; Nanovaccine Institute, Ames, IA 50011, USA.; PK Biosciences Corporation, Ames, IA 50011, USA.; Department of Physiology and Pharmacology, University of Georgia, Athens, GA 30602, USA., Narasimhan B; Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA.; Nanovaccine Institute, Ames, IA 50011, USA., Mallapragada SK; Department of Chemical and Biological Engineering, Iowa State University, Ames, IA 50011, USA.; Nanovaccine Institute, Ames, IA 50011, USA.

Publikováno v: Biomolecules [Biomolecules] 2023 Jul 31; Vol. 13 (8). Date of Electronic Publication: 2023 Jul 31.

Advances in DNA, histone, and RNA methylation mechanisms in the pathophysiology of alcohol use disorder.

Autor: Cruise TM; Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States., Kotlo K; Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States., Malovic E; Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States., Pandey SC; Center for Alcohol Research in Epigenetics, Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, United States.; Jesse Brown Veterans Affairs Medical Center, Chicago, IL, United States.

Publikováno v: Advances in drug and alcohol research [Adv Drug Alcohol Res] 2023 Feb 15; Vol. 3, pp. 10871. Date of Electronic Publication: 2023 Feb 15 (Print Publication: 2023).

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Environmental neurotoxic pesticide exposure induces gut inflammation and enteric neuronal degeneration by impairing enteric glial mitochondrial function in pesticide models of Parkinson's disease: Potential relevance to gut-brain axis inflammation in Parkinson's disease pathogenesis.

Autor: Palanisamy BN; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Sarkar S; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA; Brigham and Women's Hospital, Harvard Medical School, USA., Malovic E; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Samidurai M; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA., Charli A; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA; Charles River Laboratories International, Inc., USA., Zenitsky G; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA; Center for Brain Sciences and Neurodegenerative Diseases, Department of Physiology and Pharmacology, University of Georgia, GA 30602, USA., Jin H; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA; Center for Brain Sciences and Neurodegenerative Diseases, Department of Physiology and Pharmacology, University of Georgia, GA 30602, USA., Anantharam V; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA; Center for Brain Sciences and Neurodegenerative Diseases, Department of Physiology and Pharmacology, University of Georgia, GA 30602, USA., Kanthasamy A; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA; Center for Brain Sciences and Neurodegenerative Diseases, Department of Physiology and Pharmacology, University of Georgia, GA 30602, USA., Kanthasamy AG; Parkinson's Disorder Research Program, Iowa Center for Advanced Neurotoxicology, Department of Biomedical Sciences, Iowa State University, Ames, IA 50011, USA; Center for Brain Sciences and Neurodegenerative Diseases, Department of Physiology and Pharmacology, University of Georgia, GA 30602, USA. Electronic address: anumantha.kanthasamy@uga.edu.

Publikováno v: The international journal of biochemistry & cell biology [Int J Biochem Cell Biol] 2022 Jun; Vol. 147, pp. 106225. Date of Electronic Publication: 2022 May 12.