Diagnosis of Thrombotic Thrombocytopenic Purpura by ADAMTS13 Activity Quantification

Autor: Konstantinos Dimopoulos, Malou Philips, Jens P Goetze

Publikováno v: Dimopoulos, K, Philips, M & Goetze, J P 2022, ' Diagnosis of Thrombotic Thrombocytopenic Purpura by ADAMTS13 Activity Quantification ', The journal of applied laboratory medicine, vol. 7, no. 3, pp. 637-649 . https://doi.org/10.1093/jalm/jfab148

Background Rapid quantification of ADAMTS13 activity in plasma is essential for establishing a diagnosis of thrombotic thrombocytopenic purpura (TTP); a rare, but potentially lethal disorder. The current methods for quantitating ADAMTS13 activity are

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a2660a2083be8977d4d84a31925b1af
https://curis.ku.dk/portal/da/publications/diagnosis-of-thrombotic-thrombocytopenic-purpura-by-adamts13-activity-quantification(65cf2c3c-1ace-41bd-85d3-73ffd311548a).html

[Diagnosing von Willebrand disease]

Autor: Fie Juhl, Vojdeman, Malou, Philips, Eva, Funding, Jens Peter, Gøtze

Publikováno v: Ugeskrift for laeger. 181(16)

Von Willebrand disease (VWD) is an inherited bleeding disorder with abnormal primary haemostasis due to defects in, or decreased concentration of the glycoprotein von Willebrand factor. In Denmark, the estimated prevalence of VWD is 1% corresponding

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::356c420745ecd72e5df5c811a2002a84
https://pubmed.ncbi.nlm.nih.gov/31036151

Characterization of a novel mutation in the von Willebrand factor propeptide in a distinct subtype of recessive von Willebrand disease

Autor: Ann-Charlotte Kristoffersson, Malou Philips, Stefan Lethagen, Elsa Lanke, Lars Holmberg

Publikováno v: Thrombosis and Haemostasis. 100:211-216

SummaryvonWillebrand factor (VWF) is a plasma protein that consists of a series of multimers of which the high-molecular-weight VWF multimers are the most potent in platelet adhesion and aggre-gation. The propeptide of theVWF (VWFpp) is known to be e

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5133ba7c1ab94c54294bdc4f912b452
https://doi.org/10.1160/th08-03-0187

Characterization and Structural Impact of Five Novel PROS1 Mutations in Eleven Protein S-deficient Families

Autor: Marie Luise Bisgaard, Bent Lind, Sixtus Thorsen, Bruno O. Villoutreix, Bente Damm Andersen, Malou Philips

Publikováno v: Thrombosis and Haemostasis. 86:1392-1399

SummaryHeterozygozity for four novel missense mutations (W108C, W342R, E349K and L485S) and one novel 4 bp deletion (ACdelAAAG affecting codons 632-633) was identified in PROS1 of unrelated thrombosis prone Danish families with protein S type I or II

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::9699ec2dca0d0aa5913544358d8f0c41
https://doi.org/10.1055/s-0037-1616741

A Specific Immunologic Assay for Functional Plasminogen Activator Inhibitor 1 in Plasma – Standardized Measurements of the Inhibitor and Related Parameters in Patients with Venous Thromboembolic Disease

Autor: Anne-Grethe Juul, Bent Lind, Johan Selmer, Malou Philips, Sixtus Thorsen

Publikováno v: Thrombosis and Haemostasis. 68:486-494

SummaryA new assay for functional plasminogen activator inhibitor 1 (PAI-1) in plasma was developed. The assay is based on the quantitative conversion of PAI-1 to urokinase-type plasminogen activator (u-PA)-PAI-l complex the concentration of which is

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::8ee74650101c20b6f6e11006657c12a3
https://doi.org/10.1055/s-0038-1646305