Zobrazeno 1 - 10
of 168
pro vyhledávání: '"Malose J Mphahlele"'
Publikováno v:
Results in Chemistry, Vol 12, Iss , Pp 101896- (2024)
The rising levels of breast and cervical cancers among women have become public health problem with high economic burden globally and more especially in low- and middle-income countries. This necessitates discoving new and potent anticancer drugs wit
Externí odkaz:
https://doaj.org/article/86c9db31ac04426a87b56ab57ae905a0
Publikováno v:
Antioxidants, Vol 13, Iss 10, p 1255 (2024)
The rising levels of type 2 diabetes mellitus (T2DM) and the poor medical effects of the commercially available antidiabetic drugs necessitate the development of potent analogs to treat this multifactorial metabolic disorder. It has been demonstrated
Externí odkaz:
https://doaj.org/article/34b67d9e48384cc3b1f298a890a1ef56
Publikováno v:
Antioxidants, Vol 12, Iss 11, p 1971 (2023)
Series of the 6-bromo/iodo substituted 2-aryl-4-methyl-1,2-dihydroquinazoline-3-oxides and their mixed 6,8-dihalogenated (Br/I and I/Br) derivatives were evaluated for inhibitory properties against α-glucosidase and/or α-amylase activities and for
Externí odkaz:
https://doaj.org/article/6d54170ef25b4047a2cab6b57148ef1f
Autor:
Malose J. Mphahlele
Publikováno v:
Molecules, Vol 27, Iss 22, p 7985 (2022)
The synthesis of quinazoline 3-oxides and their derivatives has attracted considerable attention due to their reactivity as intermediates in the synthesis of quinazoline analogues and their ring-expanded derivatives. Despite this, there is no compreh
Externí odkaz:
https://doaj.org/article/6471abb79fcd41a4ad6d79dc8619922c
Autor:
Jackson K. Nkoana, Marole M. Maluleka, Malose J. Mphahlele, Richard M. Mampa, Yee Siew Choong
Publikováno v:
Molecules, Vol 27, Iss 20, p 6935 (2022)
The ambident electrophilic character of the 5-bromo-2-hydroxychalcones and the binucleophilic nature of 2-aminothiophenol were exploited to construct the 2-aryl-4-(4-bromo-2-hydroxyphenyl)benzo[1,5]thiazepines. The structures and conformation of thes
Externí odkaz:
https://doaj.org/article/a2e6b44a2a0c469eaa74cc93dc520df0
Publikováno v:
Journal of Enzyme Inhibition and Medicinal Chemistry, Vol 33, Iss 1, Pp 1516-1528 (2018)
A series of 2-arylbenzo[b]furan–appended 4-aminoquinazoline hybrids were prepared and evaluated for cytotoxicity in vitro against the human lung cancer (A549), colorectal adenocarcinoma (Caco-2), hepatocellular carcinoma (C3A) and cervical cancer (
Externí odkaz:
https://doaj.org/article/3e7d4bce138141f6b0604661811a732a
Autor:
Malose J. Mphahlele
Publikováno v:
Molecules, Vol 26, Iss 19, p 5923 (2021)
Sulfonamidochalcones continue to assert themselves as versatile synthetic intermedi-ates and several articles continue to appear in literature describing their synthesis, chemical transformation and biological properties. These compounds are not only
Externí odkaz:
https://doaj.org/article/054437a0e9f84f6aa47bbb5b6e4c58a2
Autor:
Malose J. Mphahlele, Marole M. Maluleka, Yee Siew Choong, Bernice A. Monchusi, Vusi G. Mbazima
Publikováno v:
Medicinal Chemistry Research. 31:2243-2259
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7830857b4b5c8675020cabf856453e39
https://doi.org/10.1007/s00044-022-02980-1
https://doi.org/10.1007/s00044-022-02980-1
Publikováno v:
Medicinal Chemistry Research. 31:2132-2151
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9601926ac62b043b2a1b5ddd0bad65b0
https://doi.org/10.1007/s00044-022-02972-1
https://doi.org/10.1007/s00044-022-02972-1
Publikováno v:
Molecules, Vol 26, Iss 9, p 2692 (2021)
The 2-amino-5-(3/4-fluorostyryl)acetophenones were prepared and reacted with benzaldehyde derivatives to afford the corresponding 5-styryl-2-aminochalcone hybrids. The trans geometry of the styryl and α,β-unsaturated carbonyl arms, and the presence
Externí odkaz:
https://doaj.org/article/6224b70469e54f938f2b5c07e6d63720