Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Mallory A. van Dongen"'
Autor:
Casey A. Dougherty, Mark M. Banaszak Holl, Junjie Chen, Rachel L. Merzel, Bradford G. Orr, Philip S. Low, E. Neil G. Marsh, Mallory A. van Dongen, Ananda Kumar Kanduluru
Publikováno v:
Biomacromolecules. 17:922-927
Polymer-ligand conjugates are designed to bind proteins for applications as drugs, imaging agents, and transport scaffolds. In this work, we demonstrate a folic acid (FA)-triggered exosite binding of a generation five poly(amidoamine) (G5 PAMAM) dend
Autor:
Rong Qi, Yunan Wang, Yini Cao, Chao Wang, Qiang Zhang, Siling Wang, Mark M. Banaszak Holl, Heran Zhang, Lu Xu, Bing He, George Liu, Wenwen Shen, Mallory A. van Dongen, Cong Chen
Publikováno v:
Nanomedicine: Nanotechnology, Biology and Medicine. 11:1141-1151
This study compared formulation effects of a dendrimer and a liposome preparation on the water solubility, transepithelial transport, and oral bioavailability of simvastatin (SMV). Amine-terminated G5 PAMAM dendrimer (G5-NH 2 ) was chosen to form SMV
Autor:
Kevin Anderson, Milan Kaushik, Casey A. Dougherty, Christina N. Kelly, Sriram Vaidyanathan, Rachel L. Merzel, Mallory A. van Dongen, Mark M. Banaszak Holl, Bradford G. Orr, Binyamin Jacobovitz
Publikováno v:
ACS Nano. 9:6097-6109
Cationic gene delivery agents (vectors) are important for delivering nucleotides, but are also responsible for cytotoxicity. Cationic polymers (L-PEI, jetPEI, and G5 PAMAM) at 1x to 100x the concentrations required for translational activity (protein
Autor:
Maomao Yu, Mark M. Banaszak Holl, George Liu, Cong Chen, Qian Ma, Siling Wang, Rong Qi, Yini Cao, Lu Xu, Bing He, Mallory A. van Dongen, Yingchun Han, Huayu Zhang, Qiang Zhang, Yanzhi Li, Wenwen Shen
Publikováno v:
Molecular Pharmaceutics. 12:665-674
Probucol (PB), an antioxidant drug, is commonly used as a lipid concentration lowering drug to reduce blood plasma cholesterol levels in the clinic. However, the therapeutic effects of this drug are negatively impacted by its poor water solubility an
Autor:
Mallory A. van Dongen, Yingchun Han, Mark M. Banaszak Holl, Yanzhi Li, George Liu, Rong Qi, Maomao Yu, Wenwen Shen
Publikováno v:
European Journal of Pharmaceutics and Biopharmaceutics. 88:658-663
To improve gene delivery efficiency of PEGylated poly(amidoamine) dendrimers in livers and muscles, the roles of syndecan-4 receptor and caveolin-1 protein in the endocytosis of PEGylated generation 5 (G5-PEG) or 7 (G7-PEG) dendrimers and plasmid DNA
Autor:
Philip S. Low, Justin E. Silpe, Mark M. Banaszak Holl, Seok-Ki Choi, Bradford G. Orr, Ananda Kumar Kanduluru, Mallory A. van Dongen, Casey A. Dougherty
Publikováno v:
Molecular Pharmaceutics
Multivalent conjugation of folic acid has been employed to target cells overexpressing folate receptors. Such polymer conjugates have been previously demonstrated to have high avidity to folate binding protein. However, the lack of a monovalent folic
Autor:
Casey A. Dougherty, Stassi DiMaggio, Janet Manono, Mallory A. van Dongen, Theodore Goodson, Mark M. Banaszak Holl, Joseph C. Furgal
Publikováno v:
Chemistry - A European Journal. 20:4638-4645
Fluorescent dyes are commonly conjugated to nanomaterials for imaging applications using stochastic synthesis conditions that result in a Poisson distribution of dye/particle ratios and therefore a broad range of photophysical and biodistribution pro
Autor:
Madhuresh Sumit, Mallory A. van Dongen, Seok-Ki Choi, Mark M. Banaszak Holl, Justin E. Silpe, Baohua Huang, Bradford G. Orr, Alina Kotlyar, Thommey P. Thomas
Publikováno v:
ACS Chemical Biology. 8:2063-2071
We investigated two types of generation 5 polyamidoamine (PAMAM) dendrimers, each conjugated stochastically with a mean number of five or ten methotrexate (MTX) ligands per dendrimer (G5-MTX5, G5-MTX10), for their binding to surface-immobilized folat
Autor:
Yin Tang, Mallory A. van Dongen, Rong Qi, Xiao Yan Gu, Danielle M. Zurcher, Ri Yuan Lin, Mark M. Banaszak Holl, Bo Wang, George Liu, Yang Bing Li
Publikováno v:
Molecular Pharmaceutics. 9:1812-1821
Although siRNA techniques have been broadly applied as a tool for gene knockdown, substantial challenges remain in achieving efficient delivery and in vivo efficacy. In particular, the low efficiency of target gene silencing in vivo is a critical lim
Autor:
Kathryn E. Leach, Todd D. Krauss, Michelle L. Ingalsbe, Matthew S. Pinto, Mallory A. van Dongen, Jeanette R. Drapo, Ronny Priefer, Megan A. Baumler, John C. Cadwalader
Publikováno v:
Surface and Coatings Technology. 202:6109-6112
The use of weak polyelectrolytes in multilayer polymer systems provides a means of altering the physico-chemical properties of these thin films. This paper examines the limits of the polyanions by incorporating the extremely weak polyelectrolyte, pol