Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Mallika Valapala"'
Autor:
Haitao Liu, Nadezda A. Stepicheva, Sayan Ghosh, Peng Shang, Olivia Chowdhury, Rachel A. Daley, Meysam Yazdankhah, Urvi Gupta, Stacey L. Hose, Mallika Valapala, Christopher Scott Fitting, Anastasia Strizhakova, Yang Shan, Derrick Feenstra, José-Alain Sahel, Ashwath Jayagopal, James T. Handa, J. Samuel Zigler, Patrice E. Fort, Akrit Sodhi, Debasish Sinha
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-19 (2022)
Retinal pigment epithelium (RPE) plays an important role in diabetic retinopathy (DR) progression. Here, the authors show AKT1 and AKT2 are reciprocally regulated in the RPE of DR donor tissue and diabetic mice, reducing Akt2 in RPE causing a compens
Externí odkaz:
https://doaj.org/article/b6a04d515080449b8de555a71e4835ba
Publikováno v:
Cellular & Molecular Biology Letters, Vol 24, Iss 1, Pp 1-9 (2019)
Abstract Background Induction of lysosomal function and autophagy is regarded as an adaptive mechanism in response to cellular stress. The transcription factor EB (TFEB) has been identified as a master regulator of lysosomal function and autophagy. T
Externí odkaz:
https://doaj.org/article/5b480e78eabe4ef1a89312819a2b3b20
Autor:
Hsuan-Yeh Pan, Mallika Valapala
Publikováno v:
International Journal of Molecular Sciences, Vol 23, Iss 3, p 1709 (2022)
Autophagy is a vital cellular mechanism that benefits cellular maintenance and survival during cell stress. It can eliminate damaged or long-lived organelles and improperly folded proteins to maintain cellular homeostasis, development, and differenti
Externí odkaz:
https://doaj.org/article/b92af4a93f554269834567dd80823c64
Autor:
Hsuan-Yeh Pan, Mallika Valapala
Publikováno v:
Cells, Vol 10, Iss 10, p 2504 (2021)
Lysosomes are important for proper functioning of the retinal pigment epithelial (RPE) cells. RPE cells have a daily burden of phagocytosis of photoreceptor outer segments (POS) and also degrade cellular waste by autophagy. Here, we identified the ro
Externí odkaz:
https://doaj.org/article/bc6600ff26c849b3bc2947572da04ea5
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 16, p 8684 (2021)
Nuclear factor of activated T cells (NFAT) family of transcription factors are substrates of calcineurin and play an important role in integrating Ca2+ signaling with a variety of cellular functions. Of the five NFAT proteins (NFAT1-5), NFAT1-4 are s
Externí odkaz:
https://doaj.org/article/7132a7bc0c00438e992f97d5c505ff51
Autor:
Dawin Khiev, Zeinab A. Mohamed, Riddhi Vichare, Ryan Paulson, Sofia Bhatia, Subhra Mohapatra, Glenn P. Lobo, Mallika Valapala, Nagaraj Kerur, Christopher L. Passaglia, Shyam S. Mohapatra, Manas R. Biswal
Publikováno v:
Nanomaterials, Vol 11, Iss 1, p 173 (2021)
Ocular diseases can deteriorate vision to the point of blindness and thus can have a major impact on the daily life of an individual. Conventional therapies are unable to provide absolute therapy for all ocular diseases due to the several limitations
Externí odkaz:
https://doaj.org/article/3b2ddf5c0866428e8523d9e9697c2a52
Autor:
Sayan Ghosh, Peng Shang, Mallika Valapala, Stacey Hose, Debasish Sinha, Haitao Liu, Joseph Weiss, J. Samuel Zigler, Simon C. Watkins, Nadezda A. Stepicheva, Meysam Yazdankhah, Alan M. Watson
Publikováno v:
Cellular and Molecular Life Sciences
Lipocalins are a family of secreted adipokines which play important roles in various biological processes. Lipocalin-2 (LCN-2) has been shown to be involved in acute and chronic inflammation. This particular protein is critical in the pathogenesis of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::93d6efc159fab3aa466a58dad98364bf
https://doi.org/10.1007/s00018-019-03423-8
https://doi.org/10.1007/s00018-019-03423-8
Autor:
Mallika Valapala, Hsuan-Yeh Pan
Publikováno v:
Cells
Cells, Vol 10, Iss 2504, p 2504 (2021)
Volume 10
Issue 10
Cells, Vol 10, Iss 2504, p 2504 (2021)
Volume 10
Issue 10
Lysosomes are important for proper functioning of the retinal pigment epithelial (RPE) cells. RPE cells have a daily burden of phagocytosis of photoreceptor outer segments (POS) and also degrade cellular waste by autophagy. Here, we identified the ro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7e58f92af20328b5e0b0ae636ee3001d
http://europepmc.org/articles/PMC8534123
http://europepmc.org/articles/PMC8534123
Autor:
Haitao Liu, Nadezda A. Stepicheva, Sayan Ghosh, Peng Shang, Olivia Chowdhury, Rachel A. Daley, Meysam Yazdankhah, Urvi Gupta, Stacey L. Hose, Mallika Valapala, Christopher Scott Fitting, Anastasia Strizhakova, Yang Shan, Derrick Feenstra, José-Alain Sahel, Ashwath Jayagopal, James T. Handa, J. Samuel Zigler, Patrice E. Fort, Akrit Sodhi, Debasish Sinha
Publikováno v:
Nature communications. 13(1)
The retinal pigment epithelium (RPE) plays an important role in the development of diabetic retinopathy (DR), a leading cause of blindness worldwide. Here we set out to explore the role of Akt2 signaling—integral to both RPE homeostasis and glucose
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f630ca542560d30249d8bcd2e7a06f46
https://pubmed.ncbi.nlm.nih.gov/36229454
https://pubmed.ncbi.nlm.nih.gov/36229454
Autor:
Zeinab A. Mohamed, Christopher L. Passaglia, Glenn P. Lobo, Riddhi Vichare, Ryan J Paulson, Shyam S. Mohapatra, Nagaraj Kerur, Subhra Mohapatra, Sofia Bhatia, Dawin Khiev, Manas R. Biswal, Mallika Valapala
Publikováno v:
Nanomaterials
Nanomaterials, Vol 11, Iss 173, p 173 (2021)
Nanomaterials, Vol 11, Iss 173, p 173 (2021)
Ocular diseases can deteriorate vision to the point of blindness and thus can have a major impact on the daily life of an individual. Conventional therapies are unable to provide absolute therapy for all ocular diseases due to the several limitations
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5f3662f764836c92b05eb7ff0bf4d9b5
http://europepmc.org/articles/PMC7828028
http://europepmc.org/articles/PMC7828028