Zobrazeno 1 - 10
of 36
pro vyhledávání: '"Mallika Somayajulu"'
Autor:
Naman Gupta, Mallika Somayajulu, Katherine Gurdziel, Giovanni LoGrasso, Haidy Aziz, Rita Rosati, Sharon McClellan, Ahalya Pitchaikannu, Manoranjan Santra, Muhammed Farooq Abdul Shukkur, Paul Stemmer, Linda D. Hazlett, Shunbin Xu
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-23 (2024)
Abstract The conserved miR-183/96/182 cluster (miR-183C) is expressed in both corneal resident myeloid cells (CRMCs) and sensory nerves (CSN) and modulates corneal immune/inflammatory responses. To uncover cell type-specific roles of miR-183C in CRMC
Externí odkaz:
https://doaj.org/article/cbf9b527a8844be3b0042541dca45a86
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 7, p 3754 (2024)
We have previously shown that PM10 exposure causes oxidative stress and reduces Nrf2 protein levels, and SKQ1 pre-treatment protects against this damage in human corneal epithelial cells (HCE-2). The current study focuses on uncovering the mechanisms
Externí odkaz:
https://doaj.org/article/2725e7b39ebb43cf9c7ba0df4d2889d4
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 13 (2023)
PurposeIn vivo data indicate that mouse corneas exposed to PM10 showed early perforation and thinning after infection with Pseudomonas aeruginosa. To understand the mechanisms underlying this finding, we tested the effects of PM10 and the mitochondri
Externí odkaz:
https://doaj.org/article/06607c6591ee46d7be9b5eeab733a889
Autor:
Takhellambam S. Devi, Thangal Yumnamcha, Fayi Yao, Mallika Somayajulu, Renu A. Kowluru, Lalit P. Singh
Publikováno v:
Biology Open, Vol 11, Iss 8 (2022)
Externí odkaz:
https://doaj.org/article/a5157818f9d4463290d79c58cfc48ad7
Autor:
Mallika Somayajulu, Sharon A. McClellan, Robert Wright, Ahalya Pitchaikannu, Bridget Croniger, Kezhong Zhang, Linda D. Hazlett
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 3911 (2023)
The purpose of this study is to test the effects of whole-body animal exposure to airborne particulate matter (PM) with an aerodynamic diameter of 10) in the mouse cornea and in vitro. C57BL/6 mice were exposed to control or 500 µg/m3 PM10 for 2 wee
Externí odkaz:
https://doaj.org/article/d630535f35a54ceeb02c887f7c2069d8
Autor:
Mallika Somayajulu, Sharon A. McClellan, Denise A. Bessert, Ahalya Pitchaikannu, Linda D. Hazlett
Publikováno v:
Frontiers in Cellular and Infection Microbiology, Vol 11 (2022)
PurposeTo test the effects of acidic vs. neutral pH glycyrrhizin (GLY) on the unwounded and wounded normal mouse cornea and after infection with Pseudomonas aeruginosa isolates KEI 1025 and multidrug-resistant MDR9.MethodsAcidic or neutral GLY vs. ph
Externí odkaz:
https://doaj.org/article/6097878b03b64d698eba0d89c3da6baa
Autor:
Mallika Somayajulu, Sharon A. McClellan, Shukkur Muhammed Farooq, Ahalya Pitchaikannu, Shunbin Xu, Linda Hazlett
Publikováno v:
Pathogens, Vol 11, Iss 11, p 1327 (2022)
This study tests the mechanism(s) of glycyrrhizin (GLY) protection against P. aeruginosa keratitis. Female C57BL/6 (B6), TLR4 knockout (TLR4KO), myeloid specific TLR4KO (mTLR4KO), their wildtype (WT) littermates, and TLR9 knockout (TLR9KO) mice were
Externí odkaz:
https://doaj.org/article/215d052d27494a4d8357e72bd92d36c6
Publikováno v:
Pathogens, Vol 10, Iss 10, p 1235 (2021)
Pseudomonas (P.) aeruginosa is a Gram-negative bacteria that causes human infections. It can cause keratitis, a severe eye infection, that develops quickly and is a major cause of ulceration of the cornea and ocular complications globally. Contact le
Externí odkaz:
https://doaj.org/article/01e92936fe8741459cf5990cf2a708cb
Autor:
Takhellambam S. Devi, Thangal Yumnamcha, Fayi Yao, Mallika Somayajulu, Renu A. Kowluru, Lalit P. Singh
Publikováno v:
Biology Open, Vol 8, Iss 4 (2019)
Thioredoxin-interacting protein (TXNIP) plays a critical role in oxidative stress, inflammation, apoptosis and the pathogenesis of diabetic retinopathy (DR). However, the role of TXNIP in high glucose-induced retinal pigment epithelium (RPE) dysfunct
Externí odkaz:
https://doaj.org/article/b6086501b8f34c7a8d8c08f188463ba1
Autor:
Nicholas J. Carruthers, Sharon A. McClellan, Mallika Somayajulu, Ahalya Pitchaikannu, Denise Bessert, Xudong Peng, Kylie Huitsing, Paul M. Stemmer, Linda D. Hazlett
Publikováno v:
Pathogens, Vol 9, Iss 9, p 766 (2020)
The effects of glycyrrhizin (GLY) on multi-drug resistant (MDR) systemic (MDR9) vs. ocular (B1045) Pseudomonas aeruginosa clinical isolates were determined. Proteomes of each isolate with/without GLY treatment were profiled using liquid chromatograph
Externí odkaz:
https://doaj.org/article/daeabacd7afa418ab757d03b2573d45d