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pro vyhledávání: '"Mallika Nagarajan"'
Autor:
G. V. Shivashankar, Saradha Venkatachalapathy, Mallika Nagarajan, Anastasiya Belyaeva, Caroline Uhler
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance We develop a network analysis approach for identifying clusters of interactions between chromosomes, which we validate experimentally. Our method integrates 1D features of the genome, such as epigenetic marks, with 3D interactions, allow
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::df0bf565ee9316f4207f08df4f0363fc
https://doi.org/10.1073/pnas.1708028115
https://doi.org/10.1073/pnas.1708028115
Autor:
G. V. Shivashankar, Mallika Nagarajan, Prasuna Ratna, Doorgesh Sharma Jokhun, Saradha Venkatachalapathy, Bibhas Roy, Yejun Wang
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America. 115(21)
Cells in tissues undergo transdifferentiation programs when stimulated by specific mechanical and biochemical signals. While seminal studies have demonstrated that exogenous biochemical factors can reprogram somatic cells into pluripotent stem cells,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8e33c9e63c54c1a365a5494c6de99e7
https://pubmed.ncbi.nlm.nih.gov/29735717
https://pubmed.ncbi.nlm.nih.gov/29735717
Autor:
Anastasiya Belyaeva, Saradha Venkatachalapathy, G. V. Shivashankar, Caroline Uhler, Mallika Nagarajan
Publikováno v:
BCB
The three-dimensional structure of the genome plays a key role in regulatory control of the cell. Chromosomes are organized nonrandomly inside the nucleus and form a network of interactions. Recent experimental methods such as Hi-C have been used to
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::c07ca576e185ac1b6fd2b88ce3927421
https://doi.org/10.1145/3107411.3108216
https://doi.org/10.1145/3107411.3108216
Publikováno v:
Molecular Biology of the Cell
A combination of experiments and ellipsoid packing models elucidate the critical role of cell geometry in the 3D organization of chromosomes and gene expression. The results show that transcription-dependent chromosome positions, their orientations,
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8f6f9b46c362628b7e89c2f7a5c7e3e7
https://repository.ist.ac.at/892/
https://repository.ist.ac.at/892/
Autor:
Mallika Nagarajan, Shovamayee Maharana, Yejun Wang, Shefali Talwar, K. Venkatesan Iyer, Nikhil Jain, G. V. Shivashankar
Publikováno v:
Methods (San Diego, Calif.). 123
In this article, we summarize current findings for the emergence of biophysical properties such as nuclear stiffness, chromatin compaction, chromosome positioning, and chromosome intermingling during stem cell differentiation, which eventually correl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::520d0518f86c5d98e829b7169b804316
https://pubmed.ncbi.nlm.nih.gov/28554525
https://pubmed.ncbi.nlm.nih.gov/28554525
Autor:
Yejun Wang, Shovamayee Maharana, Nikhil Jain, G. V. Shivashankar, K. Venkatesan Iyer, Mallika Nagarajan
Publikováno v:
Nucleic Acids Research
Chromosome territories (CTs) in higher eukaryotes occupy tissue-specific non-random three-dimensional positions in the interphase nucleus. To understand the mechanisms underlying CT organization, we mapped CT position and transcriptional changes in u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bf9f1d2d70be8dc26068c89499a41641
https://pubmed.ncbi.nlm.nih.gov/26939888
https://pubmed.ncbi.nlm.nih.gov/26939888
Publikováno v:
Biophysical Journal. 108:540a
Recent studies have revealed that cell geometric constraints regulate cytoskeleton as well as nuclear architecture, and gene expression. In addition, the spatial and temporal organization of chromosomes has been shown to modulate gene expression. How
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::420722f98cf843b3fc5afdadb6628490
https://doi.org/10.1016/j.bpj.2014.11.2960
https://doi.org/10.1016/j.bpj.2014.11.2960
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