Zobrazeno 1 - 10
of 71
pro vyhledávání: '"Malliga R. Iyer"'
Autor:
Biswajit Kundu, Szabolcs Dvorácskó, Abhishek Basu, Lenny Pommerolle, Kyu Ah Kim, Casey M. Wood, Eve Gibbs, Madeline Behee, Nadya I. Tarasova, Resat Cinar, Malliga R. Iyer
Publikováno v:
Molecules, Vol 29, Iss 13, p 3036 (2024)
The inhibition of soluble epoxide hydrolase (sEH) can reduce the level of dihydroxyeicosatrienoic acids (DHETs) effectively maintaining endogenous epoxyeicosatrienoic acids (EETs) levels, resulting in the amelioration of inflammation and pain. Conseq
Externí odkaz:
https://doaj.org/article/082c48c1d63a4249a7e91acb02de8c5e
Autor:
Johanna Becker-Baldus, Alexei Yeliseev, Thomas T. Joseph, Snorri Th. Sigurdsson, Lioudmila Zoubak, Kirk Hines, Malliga R. Iyer, Arjen van den Berg, Sam Stepnowski, Jon Zmuda, Klaus Gawrisch, Clemens Glaubitz
Publikováno v:
ACS Omega, Vol 8, Iss 36, Pp 32963-32976 (2023)
Externí odkaz:
https://doaj.org/article/543ddeac6e3345cbaafa6a8240ec5d13
Autor:
Elias C. Padilha, Mengbi Yang, Pranav Shah, Amy Q. Wang, Jianmin Duan, Joshua K. Park, Charles N. Zawatsky, May Christine V. Malicdan, George Kunos, Malliga R. Iyer, Geneviève Gaucher, François Ravenelle, Resat Cinar, Xin Xu
Publikováno v:
Biomedicine & Pharmacotherapy, Vol 168, Iss , Pp 115178- (2023)
Hermansky-Pudlak syndrome (HPS) is a rare autosomal recessive disorder that affects lysosome-related organelles, often leading to fatal pulmonary fibrosis (PF). The search for a treatment for HPS pulmonary fibrosis (HPSPF) is ongoing. S-MRI-1867, a d
Externí odkaz:
https://doaj.org/article/1588916561494097bd24648713f8ed8a
Autor:
Pinaki Bhattacharjee, Malliga R. Iyer
Publikováno v:
Pharmaceuticals, Vol 16, Iss 9, p 1235 (2023)
The cannabinoid receptors CB1 and CB2 are class A G protein-coupled receptors (GPCRs) that are activated via endogenous lipids called endocannabinoids. The endocannabinoid system (ECS) plays a critical role in the regulation of several physiological
Externí odkaz:
https://doaj.org/article/529b4e9ab59842c1b583008c6d0d8f9e
Autor:
Alexei Yeliseev, Malliga R. Iyer, Thomas T. Joseph, Nathan J. Coffey, Resat Cinar, Lioudmila Zoubak, George Kunos, Klaus Gawrisch
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-18 (2021)
Abstract Signaling through integral membrane G protein-coupled receptors (GPCRs) is influenced by lipid composition of cell membranes. By using novel high affinity ligands of human cannabinoid receptor CB2, we demonstrate that cholesterol increases b
Externí odkaz:
https://doaj.org/article/f7405dfa40aa4301afa918bbd3f3c38d
Autor:
Charles N. Zawatsky, Joshua K. Park, Jasmina Abdalla, George Kunos, Malliga R. Iyer, Resat Cinar
Publikováno v:
Frontiers in Endocrinology, Vol 12 (2021)
Scleroderma, or systemic sclerosis, is a multi-organ connective tissue disease resulting in fibrosis of the skin, heart, and lungs with no effective treatment. Endocannabinoids acting via cannabinoid-1 receptors (CB1R) and increased activity of induc
Externí odkaz:
https://doaj.org/article/073151024c6a4eedbf2545e7f496978b
Autor:
Resat Cinar, Joshua K. Park, Charles N. Zawatsky, Nathan J. Coffey, Steven P. Bodine, Jasmina Abdalla, Tadafumi Yokoyama, Tony Jourdan, Lindsey Jay, Mei Xing G. Zuo, Kevin J. O'Brien, Junfeng Huang, Ken Mackie, Asaf Alimardanov, Malliga R. Iyer, William A. Gahl, George Kunos, Bernadette R. Gochuico, May Christine V. Malicdan
Publikováno v:
Clinical and Translational Medicine, Vol 11, Iss 7, Pp n/a-n/a (2021)
Abstract Hermansky–Pudlak syndrome (HPS) is a rare genetic disorder which, in its most common and severe form, HPS‐1, leads to fatal adult‐onset pulmonary fibrosis (PF) with no effective treatment. We evaluated the role of the endocannabinoid/C
Externí odkaz:
https://doaj.org/article/6b58354bc8cd41de976ad8a5c91da796
Autor:
Luis Santos-Molina, Alexa Herrerias, Charles N. Zawatsky, Ozge Gunduz-Cinar, Resat Cinar, Malliga R. Iyer, Casey M. Wood, Yuhong Lin, Bin Gao, George Kunos, Grzegorz Godlewski
Publikováno v:
Molecules, Vol 26, Iss 16, p 5089 (2021)
Alcohol consumption is associated with gut dysbiosis, increased intestinal permeability, endotoxemia, and a cascade that leads to persistent systemic inflammation, alcoholic liver disease, and other ailments. Craving for alcohol and its consequences
Externí odkaz:
https://doaj.org/article/a0a74c8ff11a4e9da4d73a3d7b652812
Autor:
Jehrod Brenneman, Malliga R Iyer
Fibrosis is a condition with globally high unmet medical need, and as such is a highly active area of academic and pharmaceutical research covering multiple treatment targets, organs, tissues and therapeutic approaches. Anti-fibrotic Drug Discovery i
Publikováno v:
Journal of Medicinal Chemistry. 65:16062-16098
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9be15b78aa513244694c7b787f8c6844
https://doi.org/10.1021/acs.jmedchem.2c01265
https://doi.org/10.1021/acs.jmedchem.2c01265