Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Malle Jurima-Romet"'
Autor:
Andrea Gaedigk, William L Casley, Rachel F Tyndale, Edward M Sellers, Malle Jurima-Romet, J Steven Leeder
Publikováno v:
Canadian Journal of Physiology and Pharmacology. 79:841-847
CYP2C9 is the major P450 2C enzyme in human liver and contributes to the metabolism of a number of clinically important substrate drugs. This polymorphically expressed enzyme has been studied in Caucasian, Asian, and to some extent in African America
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::fde4973ef037a44667cd68bfc5994fae
https://doi.org/10.1139/y01-065
https://doi.org/10.1139/y01-065
Autor:
Albert P. Li, Malle Jurima-Romet
Publikováno v:
Cell Biology and Toxicology. 13:365-374
The utility of primary human hepatocytes in the evaluation of drug-drug interactions is being investigated in our laboratories. Our initial approach was to investigate whether drug-drug interactions observed in humans in vivo could be reproduced in v
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::ec87993a83f971cd82361d8706b180ba
https://doi.org/10.1023/a:1007451911843
https://doi.org/10.1023/a:1007451911843
Publikováno v:
Toxicology in Vitro. 10:655-663
Terfenadine has been associated with several adverse drug interactions and it was of interest to develop in vitro systems to explain and predict such interactions. The metabolism of terfenadine was studied using intact hepatocytes from primary human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c56346fd40e92d8c2349877915734bb
https://doi.org/10.1016/s0887-2333(96)00056-2
https://doi.org/10.1016/s0887-2333(96)00056-2
Publikováno v:
Toxicology. 112:69-85
Valproic acid (VPA) and the unsaturated metabolites, 2-ene VPA and (E)-2,(Z)-3'-diene VPA, demonstrated dose-dependent cytotoxicity in primary cultures of rat hepatocytes, as evaluated by lactate dehydrogenase (LDH) leakage. Cellular glutathione (GSH
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71e0acca4018f61f04ab8e1fa21d2a50
https://doi.org/10.1016/0300-483x(96)03352-5
https://doi.org/10.1016/0300-483x(96)03352-5
Publikováno v:
Biopharmaceutics & Drug Disposition. 14:171-179
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033a79e170086ca0f4492b0139a61319
https://doi.org/10.1002/bdd.2510140208
https://doi.org/10.1002/bdd.2510140208
Autor:
J. Fred Pritchard, Malle Jurima-Romet
Publikováno v:
Pharmaceutical Sciences Encyclopedia
Drug development is a process that proceeds through several high-level decision gates, “go/no go”, from identification of a potential therapeutic agent through to marketing a new drug product. Biomarkers can provide valuable information that can
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a85548f605e40ff5c41c8e977ac6e6e0
https://doi.org/10.1002/9780470571224.pse254
https://doi.org/10.1002/9780470571224.pse254
Autor:
Malle Jurima-Romet, Hide S. Huang
Publikováno v:
Biochemical Pharmacology. 44:1803-1810
The effects of modulators of cytochrome P450 and reduced glutathione (GSH) on the hepatotoxicity of enalapril maleate (EN) were investigated in Fischer 344 rats. Twenty-four hours following the administration of EN (1.5 to 1.8 g/kg), increased serum
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::3495cf0c79de6c298428961485568472
https://doi.org/10.1016/0006-2952(92)90075-t
https://doi.org/10.1016/0006-2952(92)90075-t
Publikováno v:
Toxicology Letters. 58:257-267
Enalapril maleate (EN) incubated with primary cultures of rat hepatocytes was cytotoxic in concentrations of 0.5 mM or greater. Toxicity was measured by release of lactate dehydrogenase (LDH) into the culture medium at 24 h. SKF525A, alpha-naphthofla
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26188d82ceb6d413b13f88aa1cd59a1b
https://doi.org/10.1016/0378-4274(91)90037-7
https://doi.org/10.1016/0378-4274(91)90037-7
Publikováno v:
Toxicology Letters. 58:269-277
The cytotoxicity of enalapril maleate (EN) in primary cultures of rat hepatocytes, at concentrations of 0.5 mM or greater, was measured by the release of lactate dehydrogenase (LDH) into the culture medium. Pretreatment of the hepatocytes with l -but
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57db00412ec2a2e285629b5496b99e3d
https://doi.org/10.1016/0378-4274(91)90038-8
https://doi.org/10.1016/0378-4274(91)90038-8