Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Malkeet, Kumar"'
Autor:
John Okombo, Malkeet Kumar, Devasha Redhi, Kathryn J. Wicht, Lubbe Wiesner, Timothy J. Egan, Kelly Chibale
Publikováno v:
ACS Infectious Diseases. 9:653-667
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a808c9aa7fae607b836d3485b45e3752
https://doi.org/10.1021/acsinfecdis.2c00592
https://doi.org/10.1021/acsinfecdis.2c00592
Autor:
Dickson Mambwe, Constance M. Korkor, Amanda Mabhula, Zama Ngqumba, Cleavon Cloete, Malkeet Kumar, Paula Ladeia Barros, Meta Leshabane, Dina Coertzen, Dale Taylor, Liezl Gibhard, Mathew Njoroge, Nina Lawrence, Janette Reader, Diogo Rodrigo Moreira, Lyn-Marie Birkholtz, Sergio Wittlin, Timothy J. Egan, Kelly Chibale
Publikováno v:
Journal of Medicinal Chemistry. 65:16695-16715
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::be13f3671115eb74fe7def09b01a1d32
https://doi.org/10.1021/acs.jmedchem.2c01516
https://doi.org/10.1021/acs.jmedchem.2c01516
Autor:
Dickson, Mambwe, Constance M, Korkor, Amanda, Mabhula, Zama, Ngqumba, Cleavon, Cloete, Malkeet, Kumar, Paula Ladeia, Barros, Meta, Leshabane, Dina, Coertzen, Dale, Taylor, Liezl, Gibhard, Mathew, Njoroge, Nina, Lawrence, Janette, Reader, Diogo Rodrigo, Moreira, Lyn-Marie, Birkholtz, Sergio, Wittlin, Timothy J, Egan, Kelly, Chibale
Publikováno v:
Journal of medicinal chemistry.
Iterative medicinal chemistry optimization of an ester-containing astemizole (AST) analogue
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::65f4798d25bb0a67ee75342f3d04a818
https://pubmed.ncbi.nlm.nih.gov/36507890
https://pubmed.ncbi.nlm.nih.gov/36507890
Autor:
Lyn-Marie Birkholtz, Dickson Mambwe, Dina Coertzen, Janette Reader, Dale Taylor, Malkeet Kumar, Mariëtte van der Watt, Kelly Chibale, Richard Ferger, Mathew Njoroge
Publikováno v:
ACS Med Chem Lett
[Image: see text] In the context of drug repositioning and expanding the existing structure–activity relationship around astemizole (AST), a new series of analogues were designed, synthesized, and evaluated for their antiplasmodium activity. Among
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3581afed6bad3935eddba74e720c7b3f
https://doi.org/10.1021/acsmedchemlett.1c00328
https://doi.org/10.1021/acsmedchemlett.1c00328
Autor:
Sergio Wittlin, Lynn Wambua, Luyanda Centani, Lauren B. Arendse, Lyn-Marie Birkholtz, Dale Taylor, Kelly Chibale, Janette Reader, Dina Coertzen, Nina Lawrence, Malkeet Kumar, Shoneeze S Renga, Peter Mubanga Cheuka, Stephen Fienberg, Godwin Akpeko Dziwornu, Mariëtte van der Watt
Publikováno v:
ACS Infectious Diseases. 7:34-46
Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive in vitro activity and in vivo efficacy in mouse models of malaria infection. Herein, we report the synthesis and antiplasmodium evaluation of a new series of amidated
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::df75b11c41574c2c365ab07859345b41
https://doi.org/10.1021/acsinfecdis.0c00481
https://doi.org/10.1021/acsinfecdis.0c00481
Autor:
Peter Mubanga, Cheuka, Luyanda, Centani, Lauren B, Arendse, Stephen, Fienberg, Lynn, Wambua, Shoneeze S, Renga, Godwin Akpeko, Dziwornu, Malkeet, Kumar, Nina, Lawrence, Dale, Taylor, Sergio, Wittlin, Dina, Coertzen, Janette, Reader, Mariette, van der Watt, Lyn-Marie, Birkholtz, Kelly, Chibale
Publikováno v:
ACS infectious diseases. 7(1)
Recent studies on 3,6-diphenylated imidazopyridazines have demonstrated impressive
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::5b31d5f4d31b055cbf9d3b039fa31aaf
https://pubmed.ncbi.nlm.nih.gov/33319990
https://pubmed.ncbi.nlm.nih.gov/33319990
Autor:
Malkeet Kumar, Getahun Abate, Digby F. Warner, Daniel F. Hoft, Kelly Chibale, Kawaljit Singh, Krupa Naran, Peter G. Ruminski, Fahreta Hamzabegovic
Publikováno v:
ACS Infectious Diseases. 2:714-725
Efflux pumps are considered a major potential contributor to the development of various forms of resistance in Mycobacterium tuberculosis leading to the emergence of multidrug-resistant tuberculosis (TB). Verapamil (VER) and tricyclic chemosensitizer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::65ec20588a96dd037ffd9b180d0357e5
https://doi.org/10.1021/acsinfecdis.6b00111
https://doi.org/10.1021/acsinfecdis.6b00111
Autor:
Bienyameen Baker, Getahun Abate, Andile H. Ngwane, Kelly Chibale, Fahreta Hamzabegovic, Ian Wiid, Daniel F. Hoft, Malkeet Kumar, Kawaljit Singh, Peter G. Ruminski
Publikováno v:
Bioorganicmedicinal chemistry. 26(4)
Novel reversed isoniazid (RINH) agents were synthesized by covalently linking isoniazid with various efflux pump inhibitor (EPI) cores and their structural motifs. These RINH agents were then evaluated for anti-mycobacterial activity against sensitiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::26e88a6dfcf83e4e9984da66b3bc1a30
https://pubmed.ncbi.nlm.nih.gov/29373270
https://pubmed.ncbi.nlm.nih.gov/29373270
Autor:
Kawaljit Singh, Elumalai Pavadai, Malkeet Kumar, Peter G. Ruminski, Kelly Chibale, Digby F. Warner, Krupa Naran
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2985-2990
New verapamil analogues were synthesized and their inhibitory activities against Mycobacterium tuberculosis H37Rv determined in vitro alone and in combination with rifampicin (RIF). Some analogues showed comparable activity to verapamil and exhibited
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::56b8d4372d8988cf858d8c56e8ff090c
https://doi.org/10.1016/j.bmcl.2014.05.022
https://doi.org/10.1016/j.bmcl.2014.05.022
Autor:
Mary Campbell, Kawaljit Singh, Fahreta Hamzabegovic, Daniel F. Hoft, Malkeet Kumar, Peter G. Ruminiski, Christopher S. Eickhoff, Kelly Chibale, Asmir Selimovic, Getahun Abate
Publikováno v:
Antimicrobial Agents and Chemotherapy
There is a growing interest in repurposing mycobacterial efflux pump inhibitors, such as verapamil, for tuberculosis (TB) treatment. To aid in the design of better analogs, we studied the effects of verapamil on macrophages and Mycobacterium tubercul
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::23c937b397fcb559f54f9a2bb95e5362
https://pubmed.ncbi.nlm.nih.gov/26643325
https://pubmed.ncbi.nlm.nih.gov/26643325