Výsledky vyhledávání - "Malkaram S. Achary"

Effects of Disease Causing Mutations on the Essential Motions in Proteins

Autor: Hampapathalu A. Nagarajaram, Malkaram S. Achary

Publikováno v: Journal of Biomolecular Structure and Dynamics. 26:609-623

This study embodies a detailed comparative analysis of the essential motions of the Wild type and the eight different disease mutant forms of the Human CYP1b1. The mutations considered in this study have been implicated in Primary Congenital Glaucoma

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::372ecf1c0c33df4d8dee4985deb73e73
https://doi.org/10.1080/07391102.2009.10507276

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Disease-Causing Mutations in Proteins: Structural Analysis of the CYP1b1 Mutations Causing Primary Congenital Glaucoma in Humans

Autor: Malkaram S. Achary, Aramati B. M. Reddy, Seyed E. Hasnain, Dorairajan Balasubramanian, Subhabrata Chakrabarti, Hampapathalu A. Nagarajaram, Niyaz Ahmed, Shirly G. Panicker, Anil K Mandal

Publikováno v: Biophysical Journal. 91(12):4329-4339

In this communication, we report an in-depth structure-based analysis of the human CYP1b1 protein carrying disease-causing mutations that are discovered in patients suffering from primary congenital glaucoma (PCG). The “wild-type” and the PCG mut

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4d2a0e74c599fe7494c29f58aeb3b748

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Design, synthesis, and evaluation of mixed imine–amine pyrrolobenzodiazepine dimers with efficient DNA binding affinity and potent cytotoxicity

Autor: N. Laxman, Ahmed Kamal, P. Ramulu, M. Deepak, Malkaram S. Achary, Hampapathalu A. Nagarajaram, O. Srinivas, Tasneem Rehana, G. Ramesh

Publikováno v: Bioorganic & Medicinal Chemistry. 12:5427-5436

Synthesis of mixed imine-amine pyrrolobenzodiazepine (PBD) dimers that are comprised of DC-81 and secondary amine (N10) of DC-81 subunits tethered to their C8 positions through alkanedioxy linkers (comprised of three and five carbons) is described. T

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a242bc18933616000ed6296b8ee8b9b9
https://doi.org/10.1016/j.bmc.2004.07.045

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Comparative docking studies of CYP1b1 and its PCG-associated mutant forms

Autor: Malkaram S. Achary, Hampapathalu A. Nagarajaram

Publikováno v: Journal of biosciences. 33(5)

Molecular docking has been used to compare and contrast the binding modes of oestradiol with the wild-type and some disease-associated mutant forms of the human CYP1b1 protein. The receptor structures used for docking were derived from molecular dyna

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f07e8ec7999655ced1f14b9357ff420e
https://pubmed.ncbi.nlm.nih.gov/19179758

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Profilin oligomerization and its effect on poly (L-proline) binding and phosphorylation

Autor: F. Aneesa, Malkaram S. Achary, K. Sathish, R. Wasia, Hampapathalu A. Nagarajaram, Surya S. Singh, M. Sairam, Radhika V. Korupolu

Publikováno v: International journal of biological macromolecules. 45(3)

Profilin is a cytoskeletal protein that interacts specifically with actin, phosphoinositides and poly (l-proline). Experimental results and in silico studies revealed that profilin exists as dimer and tetramer. Profilin oligomers possess weak affinit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::84e913e7b01f5bf5580ca5b1a9152fbd
https://pubmed.ncbi.nlm.nih.gov/19523483

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