Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells

Autor: Wang, Y., Kissenpfennig, Adrien, Mingueneau, M., Richelme, S., Perrin, P., Chevrier, S., Genton, C., Lucas, B., DiSanto, J.P., Acha-Orbea, H., Malisse, [No Value]

Publikováno v: Wang, Y, Kissenpfennig, A, Mingueneau, M, Richelme, S, Perrin, P, Chevrier, S, Genton, C, Lucas, B, DiSanto, J P, Acha-Orbea, H & Malisse, N V 2008, ' Th2 lymphoproliferative disorder of LatY136F mutant mice unfolds independently of TCR-MHC engagement and is insensitive to the action of Foxp3+ regulatory T cells. ' Journal of Immunology, vol. 180(3), pp. 1565-1575 .

Mutant mice where tyrosine 136 of linker for activation of T cells (LAT) was replaced with a phenylalanine (Lat(Y136F) mice) develop a fast-onset lymphoproliferative disorder involving polyclonal CD4 T cells that produce massive amounts of Th2 cytoki

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https://pure.qub.ac.uk/portal/en/publications/th2-lymphoproliferative-disorder-of-laty136f-mutant-mice-unfolds-independently-of-tcrmhc-engagement-and-is-insensitive-to-the-action-of-foxp3-regulatory-t-cells(a185c6bd-1c0c-4de8-b79b-b5e4662f1d35).html