Výsledky vyhledávání - "Malisetty V. Swamy"

Data from Inhibition of Azoxymethane-Induced Colorectal Cancer by CP-31398, a TP53 Modulator, Alone or in Combination with Low Doses of Celecoxib in Male F344 Rats

Autor: Levy Kopelovich, Suresh Guruswamy, Jagan M.R. Patlolla, Malisetty V. Swamy, Vernon E. Steele, Chinthalapally V. Rao

Tumor suppressor p53 plays a major role in colorectal cancer development. The present study explores the effects of p53-modulating agent CP-31398 alone and combined with celecoxib on azoxymethane-induced aberrant crypt foci (ACF) and colon adenocarci

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::80b6509a773caf125a4f4732f8ffb662
https://doi.org/10.1158/0008-5472.c.6499449.v1

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Inhibition of Azoxymethane-Induced Colorectal Cancer by CP-31398, a TP53 Modulator, Alone or in Combination with Low Doses of Celecoxib in Male F344 Rats

Autor: Jagan M.R. Patlolla, Chinthalapally V. Rao, Vernon E. Steele, Malisetty V. Swamy, Levy Kopelovich, Suresh Guruswamy

Publikováno v: Cancer Research. 69:8175-8182

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6eefc9fb8ffd62f47e47fe12aee342ab
https://doi.org/10.1158/0008-5472.can-09-1377

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Prevention and Treatment of Pancreatic Cancer by Curcumin in Combination With Omega-3 Fatty Acids

Autor: Altaf Mohammed, Jagan M.R. Patlolla, Malisetty V. Swamy, Chinthalapally V. Rao, Bhargava Citineni, Yuting Zhang

Publikováno v: Nutrition and Cancer. 60:81-89

Pancreatic cancer BxPC-3 cells were exposed to curcumin, docosahexaenoic acid (DHA), or combinations of both and analyzed for proliferation and apoptosis. Pancreatic tumor xenografts were established by injecting BxPC-3 cells into each flank of nude

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d6ec82f15df3c83ce9cdd5a9bb151ab3
https://doi.org/10.1080/01635580802416703

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S-adenosylL-methionine inhibits azoxymethane-induced colonic aberrant crypt foci in F344 rats and suppresses human colon cancer Caco-2 cell growth in 3D culture

Autor: Chinthalapally V. Rao, Malisetty V. Swamy, Chang In Choi, Vernon E. Steele, Suresh Guruswamy

Publikováno v: International Journal of Cancer. 122:25-30

S-adenosyl L-methionine (SAM) is a universal methyl group donor to various intermediary metabolites, hormones, proteins, neurotransmitters, phospholipids and nucleic acids. Deficiency of folate, which plays a role in the synthesis of SAM leads to inc

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4e9bc66914f54ac6915b7f526379883b
https://doi.org/10.1002/ijc.23031

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Chemoprevention of Familial Adenomatous Polyposis by Low Doses of Atorvastatin and Celecoxib Given Individually and in Combination to APCMin Mice

Autor: Bandaru S. Reddy, Vernon E. Steele, Chinthalapally V. Rao, Malisetty V. Swamy, Levy Kopelovich, Jagan M.R. Patlolla

Publikováno v: Cancer Research. 66:7370-7377

Preclinical and clinical studies have established evidence that cyclooxygenase-2 (COX-2) inhibitors and statins [hydroxy-3-methylglutaryl CoA reductase (HMGR) inhibitors] inhibit colon carcinogenesis. Chronic use of high doses of COX-2 inhibitors may

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a120b8b5393f21241774d847fe9f8944
https://doi.org/10.1158/0008-5472.can-05-4619

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β-Escin inhibits colonic aberrant crypt foci formation in rats and regulates the cell cycle growth by inducing p21waf1/cip1 in colon cancer cells

Autor: Chinthalapally V. Rao, Malisetty V. Swamy, Jagan M.R. Patlolla, Jayadev Raju

Publikováno v: Molecular Cancer Therapeutics. 5:1459-1466

Extracts of Aesculus hippocastanum (horse chestnut) seed have been used in the treatment of chronic venous insufficiency, edema, and hemorrhoids. Most of the beneficial effects of horse chestnut are attributed to its principal component β-escin or a

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a563d988b695b199145b788c0e908e29
https://doi.org/10.1158/1535-7163.mct-05-0495

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Colonic tumorigenesis in BubR1 +/– Apc Min /+ compound mutant mice is linked to premature separation of sister chromatids and enhanced genomic instability

Autor: Yuqiang Fang, Yang-Ming Yang, Radma Mahmood, Wei Dai, Chinthalapally V. Rao, Malisetty V. Swamy, Tongyi Liu, Meena Jhanwar-Uniyal

Publikováno v: Proceedings of the National Academy of Sciences. 102:4365-4370

Faithful chromosome segregation is essential for the maintenance of genetic stability during cell division and it is at least partly monitored by the spindle checkpoint, a surveillance mechanism preventing the cell from prematurely entering anaphase.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e5c117e5f73557a38b21b0b12e91025f
https://doi.org/10.1073/pnas.0407822102

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Diosgenin, a Steroid Saponin of Trigonella foenum graecum (Fenugreek), Inhibits Azoxymethane-Induced Aberrant Crypt Foci Formation in F344 Rats and Induces Apoptosis in HT-29 Human Colon Cancer Cells

Autor: Jayadev Raju, Jagan M.R. Patlolla, Malisetty V. Swamy, Chinthalapally V. Rao

Publikováno v: Cancer Epidemiology, Biomarkers & Prevention. 13:1392-1398

Trigonella foenum graecum (fenugreek) is traditionally used to treat disorders such as diabetes, high cholesterol, wounds, inflammation, and gastrointestinal ailments. Recent studies suggest that fenugreek and its active constituents may possess anti

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::31bfee0d505e27940b00907179909ace
https://doi.org/10.1158/1055-9965.1392.13.8

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