Výsledky vyhledávání - "Malini S. Iyer"

Akademický článek

Exenatide Treatment Alone Improves β-Cell Function in a Canine Model of Pre-Diabetes.

Autor: Viorica Ionut, Orison O Woolcott, Hasmik J Mkrtchyan, Darko Stefanovski, Morvarid Kabir, Malini S Iyer, Huiwen Liu, Ana V B Castro, Qiang Wu, Josiane L Broussard, Cathryn M Kolka, Isaac Asare-Bediako, Richard N Bergman

Publikováno v: PLoS ONE, Vol 11, Iss 7, p e0158703 (2016)

BACKGROUND:Exenatide's effects on glucose metabolism have been studied extensively in diabetes but not in pre-diabetes. OBJECTIVE:We examined the chronic effects of exenatide alone on glucose metabolism in pre-diabetic canines. DESIGN AND METHODS:Aft

Externí odkaz: https://doaj.org/article/3d07c96e1c694a449ba3fa19f177f099

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Akademický článek

High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets.

Autor: Orison O Woolcott, Joyce M Richey, Morvarid Kabir, Robert H Chow, Malini S Iyer, Erlinda L Kirkman, Darko Stefanovski, Maya Lottati, Stella P Kim, L Nicole Harrison, Viorica Ionut, Dan Zheng, Isabel R Hsu, Karyn J Catalano, Jenny D Chiu, Heather Bradshaw, Qiang Wu, Cathryn M Kolka, Richard N Bergman

Publikováno v: PLoS ONE, Vol 10, Iss 4, p e0123558 (2015)

BACKGROUND:Obesity has been associated with elevated plasma anandamide levels. In addition, anandamide has been shown to stimulate insulin secretion in vitro, suggesting that anandamide might be linked to hyperinsulinemia. OBJECTIVE:To determine whet

Externí odkaz: https://doaj.org/article/a9550449b61140ec87d3e78492fae4f0

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Activation of NPRs and UCP1-independent pathway following CB1R antagonist treatment is associated with adipose tissue beiging in fat-fed male dogs

Autor: Deborah J. Clegg, Malini S. Iyer, Joyce M. Richey, Richard N. Bergman, Cathryn M. Kolka, Rebecca L. Paszkiewicz, Orison O. Woolcott, Morvarid Kabir, Stella P. Kim, Darko Stefanovski, Qiang Wu, Isaac Asare-Bediako

Publikováno v: Am J Physiol Endocrinol Metab

CB1 receptor (CB1R) antagonism improves the deleterious effects of a high-fat diet (HFD) by reducing body fat mass and adipocyte cell size. Previous studies demonstrated that the beneficial effects of the CB1R antagonist rimonabant (RIM) in white adi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4ec37d0ddc22f0680601c1fd72b914c1
https://doi.org/10.1152/ajpendo.00539.2018

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A Peripheral CB1R Antagonist Increases Lipolysis, Oxygen Consumption Rate, and Markers of Beiging in 3T3-L1 Adipocytes Similar to RIM, Suggesting that Central Effects Can Be Avoided

Autor: Aaron P. Frank, Morvarid Kabir, Orison O. Woolcott, Rebecca L. Paszkiewicz, Malini S. Iyer, Roberta de Souza Santos, Richard N. Bergman, Deborah J. Clegg, Darko Stefanovski

Publikováno v: International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6639, p 6639 (2020)
Volume 21
Issue 18

With the increased prevalence of obesity and related co-morbidities, such as type 2 diabetes (T2D), worldwide, improvements in pharmacological treatments are necessary. The brain- and peripheral-cannabinoid receptor 1 (CB1R) antagonist rimonabant (RI

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e2d2e387fc0c0eba1e20ea1b7def53d7
https://pubmed.ncbi.nlm.nih.gov/33922401

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Insulin Access to Skeletal Muscle is Preserved in Obesity Induced by Polyunsaturated Diet

Autor: Malini S. Iyer, Isaac Asare Bediako, Rebecca L. Paszkiewicz, Richard N. Bergman, Josiane L. Broussard, Cathryn M. Kolka

Publikováno v: Obesity. 26:119-125

OBJECTIVE Diets high in saturated fat induce obesity and insulin resistance and impair insulin access to skeletal muscle, leading to reduced insulin levels at the muscle cell surface available to bind insulin receptors and induce glucose uptake. In c

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e38473d16ba2eb3cda811e94da3e4525
https://doi.org/10.1002/oby.22057

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Indirect Regulation of Endogenous Glucose Production by Insulin: The Single Gateway Hypothesis Revisited

Autor: Richard N. Bergman, Malini S. Iyer

Publikováno v: Diabetes. 66:1742-1747

On the basis of studies that investigated the intraportal versus systemic insulin infusion and transendothelial transport of insulin, we proposed the “single gateway hypothesis,” which supposes an indirect regulation of hepatic glucose production

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3829502fcfebc43b9a8505c6b5a340db
https://doi.org/10.2337/db16-1320

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1761-P: Brain-Restricted CB1-Receptor Antagonists Increase Oxygen Consumption Rate and Promote Beiging in 3T3-L1 Adipocytes Similar to Rimonabant Suggesting that Central Effects Can Be Avoided

Autor: Roberta de Souza Santos, Morvarid Kabir, Malini S. Iyer, Deborah J. Clegg, Rebecca K. Paszkiewicz, Orison O. Woolcott, Aaron P. Frank, Richard N. Bergman

Publikováno v: Diabetes. 68

We have previously demonstrated in dogs that following exposure to a high fat diet for 16 weeks, the brain and peripheral penetrating CB1R antagonist Rimonabant (RIM) promoted adipose tissue beiging and decreased adipocyte cell size. It is hoped that

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::e51c4d73ee86ec93e16ca12e1fa6ae8f
https://doi.org/10.2337/db19-1761-p

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