Zobrazeno 1 - 10
of 68
pro vyhledávání: '"Malini Menon"'
Autor:
Malini Menon, Roli Budhwar, Rohit Nandan Shukla, Kiran Bankar, Madavan Vasudevan, Udaykumar Ranga
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
The natural cysteine to serine variation at position 31 of Tat in HIV-1C disrupts the dicysteine motif attenuating the chemokine function of Tat. We ask if there exists a trade-off in terms of a gain of function for HIV-1C Tat due to this natural var
Externí odkaz:
https://doaj.org/article/aaeae2a74e914be49cb434cb386a5e14
Autor:
Stephen J. Pettitt, Dragomir B. Krastev, Inger Brandsma, Amy Dréan, Feifei Song, Radoslav Aleksandrov, Maria I. Harrell, Malini Menon, Rachel Brough, James Campbell, Jessica Frankum, Michael Ranes, Helen N. Pemberton, Rumana Rafiq, Kerry Fenwick, Amanda Swain, Sebastian Guettler, Jung-Min Lee, Elizabeth M. Swisher, Stoyno Stoynov, Kosuke Yusa, Alan Ashworth, Christopher J. Lord
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-14 (2018)
The mechanisms of PARP inhibitor (PARPi) resistance are poorly understood. Here the authors employ a CRISPR mutagenesis approach to identify PARP1 mutants causing PARPi resistance and find that PARP1 mutations are tolerated in BRCA1 mutated cells, su
Externí odkaz:
https://doaj.org/article/1eb977c74fb546b0a7321e49be5d0643
Autor:
Christopher J. Lord, Alan Ashworth, Stephen J. Pettitt, Nicholas C. Turner, Aditi Gulati, James Campbell, Nicholas Badham, Rumana Rafiq, Jessica Frankum, Helen N. Pemberton, Isaac Garcia-Murillas, Asha Konde, Malini Menon, Inger Brandsma, Rachel Brough, Chris T. Williamson, Amy Dréan
Figure S1: Characterisation of CAPAN1-B2S* Figure S2: Characterisation of SUM149-B1S* Figure S3: Sensitivity of ddPCR assay. Figure S4: Olaparib and talazoparib select for secondary mutant tumour cells. Figure S5: DLD1 tumour cells have a fitness adv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5c87fbc8e38f13dde6b24d9910847b29
https://doi.org/10.1158/1535-7163.22508823.v1
https://doi.org/10.1158/1535-7163.22508823.v1
Autor:
Christopher J. Lord, Alan Ashworth, Andrew N.J. Tutt, Jos Jonkers, Patrick W.B. Derksen, Colm J. Ryan, Rachael Natrajan, Spiros Linardopoulos, Mitch Dowsett, Lesley-Ann Martin, Elinor J. Sawyer, Fredrik Wallberg, Patrycja Gazinska, Irene Chong, Marta Llorca Cardenosa, Mark D. Gurden, Stephen J. Pettitt, Rahul Kumar, Aditi Gulati, James Campbell, Malini Menon, Dragomir B. Krastev, Asha Konde, Rumana Rafiq, Feifei Song, Jessica Frankum, Helen N. Pemberton, Rachel Brough, Marieke van de Ven, Rebecca Marlow, Ilirjana Bajrami
Lagging chromosomes in E-cadherin defective cell exposed to foretinib leading to failed cytokinesis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a46a503990fcd013cf24e9120ca5907e
https://doi.org/10.1158/2159-8290.22532777.v1
https://doi.org/10.1158/2159-8290.22532777.v1
Autor:
Christopher J. Lord, Alan Ashworth, Andrew N.J. Tutt, Jos Jonkers, Patrick W.B. Derksen, Colm J. Ryan, Rachael Natrajan, Spiros Linardopoulos, Mitch Dowsett, Lesley-Ann Martin, Elinor J. Sawyer, Fredrik Wallberg, Patrycja Gazinska, Irene Chong, Marta Llorca Cardenosa, Mark D. Gurden, Stephen J. Pettitt, Rahul Kumar, Aditi Gulati, James Campbell, Malini Menon, Dragomir B. Krastev, Asha Konde, Rumana Rafiq, Feifei Song, Jessica Frankum, Helen N. Pemberton, Rachel Brough, Marieke van de Ven, Rebecca Marlow, Ilirjana Bajrami
The cell adhesion glycoprotein E-cadherin (CDH1) is commonly inactivated in breast tumors. Precision medicine approaches that exploit this characteristic are not available. Using perturbation screens in breast tumor cells with CRISPR/Cas9-engineered
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::06a759d0659ac60046b51092f46f3457
https://doi.org/10.1158/2159-8290.c.6546827
https://doi.org/10.1158/2159-8290.c.6546827
Autor:
Christopher J. Lord, Alan Ashworth, Andrew N.J. Tutt, Jos Jonkers, Patrick W.B. Derksen, Colm J. Ryan, Rachael Natrajan, Spiros Linardopoulos, Mitch Dowsett, Lesley-Ann Martin, Elinor J. Sawyer, Fredrik Wallberg, Patrycja Gazinska, Irene Chong, Marta Llorca Cardenosa, Mark D. Gurden, Stephen J. Pettitt, Rahul Kumar, Aditi Gulati, James Campbell, Malini Menon, Dragomir B. Krastev, Asha Konde, Rumana Rafiq, Feifei Song, Jessica Frankum, Helen N. Pemberton, Rachel Brough, Marieke van de Ven, Rebecca Marlow, Ilirjana Bajrami
Supplementary Tables
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f28bf3060e5900c4f58b2c83cd17c64
https://doi.org/10.1158/2159-8290.22532786.v1
https://doi.org/10.1158/2159-8290.22532786.v1
Autor:
Christopher J. Lord, Alan Ashworth, Stephen J. Pettitt, Nicholas C. Turner, Aditi Gulati, James Campbell, Nicholas Badham, Rumana Rafiq, Jessica Frankum, Helen N. Pemberton, Isaac Garcia-Murillas, Asha Konde, Malini Menon, Inger Brandsma, Rachel Brough, Chris T. Williamson, Amy Dréan
ddPCR probe and primer design
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::761be8a75a4e995d41eba19da335de90
https://doi.org/10.1158/1535-7163.22508817.v1
https://doi.org/10.1158/1535-7163.22508817.v1
Autor:
Christopher J. Lord, Alan Ashworth, Andrew N.J. Tutt, Jos Jonkers, Patrick W.B. Derksen, Colm J. Ryan, Rachael Natrajan, Spiros Linardopoulos, Mitch Dowsett, Lesley-Ann Martin, Elinor J. Sawyer, Fredrik Wallberg, Patrycja Gazinska, Irene Chong, Marta Llorca Cardenosa, Mark D. Gurden, Stephen J. Pettitt, Rahul Kumar, Aditi Gulati, James Campbell, Malini Menon, Dragomir B. Krastev, Asha Konde, Rumana Rafiq, Feifei Song, Jessica Frankum, Helen N. Pemberton, Rachel Brough, Marieke van de Ven, Rebecca Marlow, Ilirjana Bajrami
Supplementary Figures
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ea0f27dec90521f076ecb04df7436b19
https://doi.org/10.1158/2159-8290.22532795
https://doi.org/10.1158/2159-8290.22532795
Autor:
Christopher J. Lord, Alan Ashworth, Andrew N.J. Tutt, Jos Jonkers, Patrick W.B. Derksen, Colm J. Ryan, Rachael Natrajan, Spiros Linardopoulos, Mitch Dowsett, Lesley-Ann Martin, Elinor J. Sawyer, Fredrik Wallberg, Patrycja Gazinska, Irene Chong, Marta Llorca Cardenosa, Mark D. Gurden, Stephen J. Pettitt, Rahul Kumar, Aditi Gulati, James Campbell, Malini Menon, Dragomir B. Krastev, Asha Konde, Rumana Rafiq, Feifei Song, Jessica Frankum, Helen N. Pemberton, Rachel Brough, Marieke van de Ven, Rebecca Marlow, Ilirjana Bajrami
Supplementary Figure legends and methods
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5d07c82e10c0054f11b2153f2f4f13ad
https://doi.org/10.1158/2159-8290.22532792
https://doi.org/10.1158/2159-8290.22532792
Autor:
Christopher J. Lord, Alan Ashworth, Janet Shipley, Winette T.A. van der Graaf, Wojciech Niedzwiedz, Stephen J. Pettitt, Rachel Brough, Joanna L. Selfe, Malini Menon, Richard Elliott, Aditi Gulati, James Campbell, Helen N. Pemberton, Dragomir B. Krastev, Chris T. Williamson, Asha Konde, Jessica Frankum, Emmy D.G. Fleuren, Samuel E. Jones
This file lists the siRNAs that are significantly associated with VX-970 resistance in SYO1 SS tumour cells in which siRNA effects in VX970-exposed vs. DMSO-exposed cells were compared, quantifying resistance-causing effects as Drug Effect (DE) Z-sco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::465ef3feac3c627fe8103af7c763e9ba
https://doi.org/10.1158/0008-5472.22416726.v1
https://doi.org/10.1158/0008-5472.22416726.v1