Zobrazeno 1 - 10
of 31
pro vyhledávání: '"Malini Bajpai"'
Autor:
Harshada Desai, Megha Marathe, Varada Potdar, Prabhakar Tiwari, Ashwini Joshi, Sheetal R. Kadam, Arti Rajesh Joshi, Abhay Kulkarni, Vikram Bhosale, Avinash Hadambar, Bhavik Lodhiya, Venkatesha Udupa, Dayanidhi Behera, Sachin S. Chaudhari, Sanjib Das, Malini Bajpai, Nagaraj Gowda, Pravin S. Iyer
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-15 (2022)
Abstract The role of RORγ as a transcription factor for Th17 cell differentiation and thereby regulation of IL-17 levels is well known. Increased RORγ expression along with IL-17A levels was observed in animal models, immune cells and BAL fluid of
Externí odkaz:
https://doaj.org/article/a7d1fc806fe64770a823646dd30ddaee
Autor:
Nagaraj Gowda, Sanjib Das, Sravan Mandadi, Jagmohan Saini, Sachin Chaudhari, Ameya Deshpande, Murugan Chinnapattu, Malini Bajpai, Priyanka Pangre, Varada Potdar, Megha Marathe, Pooja Sawant, Atul Akarte, Chandrasekhar Misra, Subhadip Das, Anuj Singh, Avratanu Das, Pandurang Lambade, Chaitanya Tirumalasetty, Raju Patole, Nilanjana Biswas, Vikas Karande, Heta Shah, Dayanidhi Behera, Pravin Iyer
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
Externí odkaz:
https://doaj.org/article/3b4b03f862394120b275158b7a6d0779
Autor:
Sravan Mandadi, Sanjib Das, Malini Bajpai, Jagmohan Saini, Murugan Chinnapattu, Sanjay Patale, Sandip Patil, Nanasaheb Kadlag, Nayan Waghmare, Balasaheb Gavhane, Ameya Deshpande, Dnyaneshwar Dahale, Vidya Kattige, Priyanka Pangre, Namrata Singh, Ekta Kashyap, Megha Marathe, Jiju Mani, Atul Akarte, Chandrasekhar Misra, Subhadip Das, Anuj Singh, Pandurang Lambade, Avratanu Das, Chaitanya Tirumalasetty, Raju Patole, Nilanjana Biswas, Vikas Karande, Heta Shah, Dayanidhi Behera, Pankaj Jain, Pavankumar Sancheti, Pramod Pawar, Vinod KR, Venkatesha Udupa, Sachin S. Chaudhari, Nagaraj Gowda, Pravin S. Iyer
Publikováno v:
Cancer Research. 83:463-463
Background: Pre-clinical profile of GRC 54276, a clinical candidate with Phase 1/2 clinical trial ongoing, is presented here. GRC 54276 is a novel small molecule inhibitor of Hematopoietic progenitor kinase 1 (HPK1), a serine/threonine kinase1,2 that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::db14602386eb472679cd4689f7bc1915
https://doi.org/10.1158/1538-7445.am2023-463
https://doi.org/10.1158/1538-7445.am2023-463
Autor:
Pooja Sawant, Ameya Deshpande, Pravin Iyer, Nagaraj Gowda, Avratanu Das, Megha Marathe, Dayanidhi Behera, Subhadip Das, Sravan Mandadi, Nilanjana Biswas, Priyanka Pangre, Heta Shah, Raju Patole, Murugan Chinnapattu, Vikas Karande, Sanjib Das, Pandurang Lambade, Sachin Sundarlal Chaudhari, Chandrasekhar Misra, Anuj Singh, Chaitanya Tirumalasetty, Jagmohan S. Saini, Varada Potdar, Malini Bajpai, Atul Akarte
Publikováno v:
Journal for ImmunoTherapy of Cancer, Vol 9, Iss Suppl 2 (2021)
BackgroundHematopoietic progenitor kinase 1 (HPK1, MAP4K1), is a negative regulator of T and B cell receptor signaling.1 2 3 A strong anti-tumor immunogenic response and tumor rejection was observed in mice with HPK1 gene knocked out.3 Treatment of H
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f91267a108a556ecb9933823dc346792
https://doaj.org/article/3b4b03f862394120b275158b7a6d0779
https://doaj.org/article/3b4b03f862394120b275158b7a6d0779
Autor:
Harshada Desai, Megha Marathe, Varada Potdar, Prabhakar Tiwari, Ashwini Joshi, Sheetal R. Kadam, Arti Rajesh Joshi, Abhay Kulkarni, Vikram Bhosale, Avinash Hadambar, Bhavik Lodhiya, Venkatesha Udupa, Dayanidhi Behera, Sachin S. Chaudhari, Sanjib Das, Malini Bajpai, Nagaraj Gowda, Pravin S. Iyer
Publikováno v:
Scientific reports. 12(1)
The role of RORγ as a transcription factor for Th17 cell differentiation and thereby regulation of IL-17 levels is well known. Increased RORγ expression along with IL-17A levels was observed in animal models, immune cells and BAL fluid of COPD pati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2edfa2b4b05cd436bf2eaf0d159f74a1
https://pubmed.ncbi.nlm.nih.gov/35610240
https://pubmed.ncbi.nlm.nih.gov/35610240
Autor:
Sheetal Kadam, Varada Potdar, Shailesh Ramesh Pardeshi, Malini Bajpai, K.R. Vinod, Venkatesha Udupa, Cynthia Caracta, Pravin Iyer, Sanjib Das, Abhay Kulkarni, Dayanidhi Behera, Shelke Sandeep Yadunath, Vikram Mansingh Bhosale, Hansraj Patil
Publikováno v:
Airway pharmacology and treatment.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f5f4bb003b0f44adfd1be4e6cf350aad
https://doi.org/10.1183/13993003.congress-2021.pa2128
https://doi.org/10.1183/13993003.congress-2021.pa2128
Autor:
Sravan Mandadi, Sanjib Das, Jagmohan Saini, Sachin S. Chaudhari, Murugan Chinnapattu, Ameya Deshpande, Dnyaneshwar Dahale, Malini Bajpai, Priyanka Pangre, Namrata Singh, Ekta Kashyap, Megha Marathe, Jiju Mani, Atul Akarte, Chandrasekhar Misra, Subhadip Das, Anuj Singh, Avratanu Das, Pandurang Lambade, Chaitanya Tirumalasetty, Raju Patole, Nilanjana Biswas, Vikas Karande, Heta Shah, Dayanidhi Behera, Pankaj Jain, Pavankumar Sancheti, Somesh Kakade, Pramod K. Pawar, Vinod KR, Venkatesha Udupa, Nagaraj Gowda, Pravin S. Iyer
Publikováno v:
Cancer Research. 82:1804-1804
Background Hematopoietic progenitor kinase 1 (HPK1) is a member of the mitogen-activated protein kinase (MAP4K) family of protein serine/threonine kinases1,2 and is a negative regulator of T and B cell receptor signaling3. Inhibition of HPK1 is an at
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dd63fad1d55c76e5ad29fc516339ed2c
https://doi.org/10.1158/1538-7445.am2022-1804
https://doi.org/10.1158/1538-7445.am2022-1804
Autor:
Pavankumar Sancheti, Somesh Kakade, Pooja Sawant, Vidya Ganapati Kattige, Vinod K. R, Pandurang Lambade, Sandeep Thorat, Raju Patole, Chandrasekhar Misra, Dayanidhi Behera, Nagaraj Gowda, Pravin Iyer, Varada Potdar, Malini Bajpai, Nilanjana Biswas, Sravan Mandadi, Subhadip Das, Sandeep Mahankali, Atul Akarte, Anuj Singh, Pankaj Jain, Pramod K. Pawar, Avratanu Das, Venkatesha Udupa, Priyanka Pangre, Sachin Sundarlal Chaudhari, Heta Shah
Publikováno v:
Cancer Research. 81:1709-1709
Background Hematopoietic progenitor kinase 1 (HPK1, MAP4K1), a member of the MAP4K family of protein serine/threonine kinases1,2 is a negative regulator of TCR and BCR3. Immunosuppressive mediators PGE2 and adenosine regulate activation of HPK13. In
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::714625dae4c53e7d04b03f4fcbca3bdd
https://doi.org/10.1158/1538-7445.am2021-1709
https://doi.org/10.1158/1538-7445.am2021-1709
Autor:
Vijayshree B. Avhad, Rajendra L. Harde, Ashwini A. Joshi, Megha Marathe, Malini Bajpai, Satyawan Jadhav, Mahamad Yunnus A. Mahat, Praveen Kumar Gupta, Sanjib Das, Neelima Khairatkar-Joshi, Maulik Nitinkumar Gandhi, Girish S. Gudi, Deepak K. Bhateja, Srinivas Gullapalli, Shelke Dnyaneshwar Eknath, A. P. Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:3238-3242
We report analogue-based rational design and synthesis of two novel series of polycyclic heteroarenes, pyrrolo[3,2-b]quinolines and pyrido[2,3-b]indoles, tethered to a biaryl system by a methyl-, ethyl- or propyl ether as PDE10A inhibitors. A number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::11a331b93cdbdc2cec527f194f2a9492
https://doi.org/10.1016/j.bmcl.2014.06.028
https://doi.org/10.1016/j.bmcl.2014.06.028
Autor:
Sanjib Das, Rajendra L. Harde, Dnyaneshwar E. Shelke, Neelima Khairatkar-Joshi, Malini Bajpai, Ratika S. Sapalya, Harshada V. Surve, Girish S. Gudi, Rambabu Pattem, Dayanidhi B. Behera, Satyawan B. Jadhav, Abraham Thomas
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 24:2073-2078
We report analogue-based rational design and synthesis of two novel series of polycyclic heteroarenes, pyrrolo[3,2-b]quinolines and pyrido[2,3-b]indoles, tethered to a biaryl system by a methyl-, ethyl- or propyl ether as PDE10A inhibitors. A number
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::60965152c23ed1f746f77808eb30258a
https://doi.org/10.1016/j.bmcl.2014.03.054
https://doi.org/10.1016/j.bmcl.2014.03.054