Zobrazeno 1 - 10
of 19
pro vyhledávání: '"Malinda Aitken"'
Autor:
Donald M. Simons, Katherine A. Weissler, Andrew J. Caton, Martha S. Jordan, Elizabeth Kropf, Malinda Aitken
Publikováno v:
European Journal of Immunology. 44:785-793
Autoreactive CD4+CD8− (CD4SP) thymocytes can be subjected to deletion when they encounter self-peptide during their development, but they can also undergo selection to become CD4SPFoxp3+ Treg cells. We have analyzed the relationship between these d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d394ebfb0aa2717d9a63da1f066aa6c6
https://doi.org/10.1002/eji.201343767
https://doi.org/10.1002/eji.201343767
Autor:
Victoria Garcia, Nardine Zakhary, David S. Garlick, Jan Erikson, E. John Wherry, Andrew J. Caton, Katherine A. Weissler, Abigail Leibow, Guang Shing Cheng, Felipe Bedoya, Elizabeth Kropf, Malinda Aitken
Publikováno v:
The Journal of Immunology. 190:6115-6125
We examined the formation, participation, and functional specialization of virus-reactive Foxp3+ regulatory T cells (Tregs) in a mouse model of influenza virus infection. “Natural” Tregs generated intrathymically, based on interactions with a sel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9ac653793bc84f815d06379d5a068c23
https://doi.org/10.4049/jimmunol.1203302
https://doi.org/10.4049/jimmunol.1203302
Autor:
Alissa Basehoar, Donald M. Simons, Andrew J. Caton, Soyoung Oh, Elizabeth Kropf, Malinda Aitken, Victoria Garcia
Publikováno v:
The Journal of Immunology. 190:3134-3141
We have examined mechanisms underlying the formation of pathologic Th17 cells using a transgenic mouse model in which autoreactive CD4+ T cells recognize influenza virus hemagglutinin (HA) as a ubiquitously expressed self-Ag and induce inflammatory a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2e8f48fb7ad7844d6dcc37331845dd13
https://doi.org/10.4049/jimmunol.1203212
https://doi.org/10.4049/jimmunol.1203212
Autor:
Elizabeth Kropf, Soyoung Oh, Malinda Aitken, Victoria Garcia, Alissa Basehoar, Andrew J. Caton, Donald M. Simons
Publikováno v:
The Journal of Immunology. 188:4171-4180
CD4+CD25+Foxp3+ regulatory T cells (Tregs) are required to restrain the immune system from mounting an autoaggressive systemic inflammatory response, but why their activity can prevent (or allow) organ-specific autoimmunity remains poorly understood.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::704401afe06f055de7d9adc08668858f
https://doi.org/10.4049/jimmunol.1103598
https://doi.org/10.4049/jimmunol.1103598
Autor:
Cristina Cozzo Picca, Olivia A. Perng, Elizabeth Kropf, Jan Erikson, Christina Mergenthaler, Malinda Aitken, Andrew J. Caton, Donald M. Simons, Soyoung Oh
Publikováno v:
Proceedings of the National Academy of Sciences. 108:14890-14895
CD4 + CD25 + Foxp3 + regulatory T (Treg) cells are generated during thymocyte development and play a crucial role in preventing the immune system from attacking the body's cells and tissues. However, how the formation of these cells is directed by T-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1d2dc82177562fd14ebc1baf929af07d
https://doi.org/10.1073/pnas.1103810108
https://doi.org/10.1073/pnas.1103810108
Autor:
Soyoung Oh, Cristina Cozzo Picca, Andrew J. Caton, Jan Erikson, Donald M. Simons, Malinda Aitken, Olivia A. Perng
Publikováno v:
Journal of Leukocyte Biology. 88:1099-1107
Review discusses studies analyzing how the immune system generates Treg cells that can recognize self-peptides and prevent harmful autoimmune responses. The cataclysmic disease that develops in mice and humans lacking CD4+ T cells expressing the tran
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8242a2e54655396fa17a1b4bbbc0c9f
https://doi.org/10.1189/jlb.0310183
https://doi.org/10.1189/jlb.0310183
Autor:
Laura Panarey, Alissa Basehoar, Andrew J. Caton, Soyoung Oh, Malinda Aitken, Cristina Cozzo Picca
Publikováno v:
European Journal of Immunology. 39:3301-3306
Autoreactive CD4+ T cells can undergo deletion and/or become CD25+Foxp3+ Treg as they develop intrathymically, but how these alternative developmental fates are specified based on interactions with self-peptide(s) is not understood. We show here that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::cc2003de9eedf80b364e0739715a570b
https://doi.org/10.1002/eji.200939709
https://doi.org/10.1002/eji.200939709
Autor:
Soyoung Oh, Brigitte Koeberlein, Cristina Cozzo Picca, Malinda Aitken, Ali Naji, Laura Panarey, Amy J. Reed, Andrew L. Rankin, Peter E. Lipsky, Joseph Larkin, Andrew J. Caton, Heath M. Guay, John E. Tomaszewski
Publikováno v:
The Journal of Immunology. 180:833-841
We have examined processes leading to the spontaneous development of autoimmune inflammatory arthritis in transgenic mice containing CD4+ T cells targeted to a nominal Ag (hemagglutinin (HA)) and coexpressing HA driven by a MHC class II promoter. Des
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a02891d1d01d53c035d818f59fa24a43
https://doi.org/10.4049/jimmunol.180.2.833
https://doi.org/10.4049/jimmunol.180.2.833
Autor:
Malinda Aitken, Andrew L. Rankin, David S. Garlick, Andrew J. Caton, Victoria Garcia, Jan Erikson, Elizabeth Kropf, Olivia A. Perng
Publikováno v:
Journal of immunology (Baltimore, Md. : 1950). 192(7)
Although therapies targeting distinct cellular pathways (e.g., anticytokine versus anti–B cell therapy) have been found to be an effective strategy for at least some patients with inflammatory arthritis, the mechanisms that determine which pathways
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e35329ddd2d8c8b051b1b00cc190d5e0
https://pubmed.ncbi.nlm.nih.gov/24591372
https://pubmed.ncbi.nlm.nih.gov/24591372
Autor:
Felipe Bedoya, Guang-Shing Cheng, Abigail Leibow, Nardine Zakhary, Katherine Weissler, Victoria Garcia, Elizabeth Kropf, Malinda Aitken, David Garlick, E. Wherry, Jan Erikson, Andrew Caton
Publikováno v:
The Journal of Immunology. 190:139.11-139.11
We have examined the formation, participation and functional specialization of virus-reactive Foxp3+ regulatory T cells (Tregs) in a mouse model of influenza virus infection. “Natural” Tregs generated intra-thymically based on interactions with a
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::17934ba5e3043ec87269ddd55fde7db8
https://doi.org/10.4049/jimmunol.190.supp.139.11
https://doi.org/10.4049/jimmunol.190.supp.139.11