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pro vyhledávání: '"Malina Barillaro"'
Autor:
Meg Schuurman, Madison Wallace, Gurleen Sahi, Malina Barillaro, Siyi Zhang, Mushfiqur Rahman, Cynthia Sawyez, Nica Borradaile, Rennian Wang
Publikováno v:
Frontiers in Endocrinology, Vol 13 (2022)
Obesity plays a major role in type II diabetes (T2DM) progression because it applies metabolic and oxidative stress resulting in dysfunctional beta-cells and activation of intra-islet pancreatic stellate cells (PaSCs) which cause islet fibrosis. Admi
Externí odkaz:
https://doaj.org/article/8011e86d23284919a5c7b83b87ddba31
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
β1-integrin is a key receptor that regulates cell-ECM interactions and is important in maintaining mature beta-cell functions, including insulin secretion. However, there is little reported about the relationship between ECM-β1-integrin interaction
Externí odkaz:
https://doaj.org/article/802e909b92a7407398b090f862e705e2
Autor:
Malina Barillaro, Tanja Gonska
Publikováno v:
Expert Review of Respiratory Medicine. :1-13
Publikováno v:
Endocrinology. 164(1)
Shortcomings in cell-based therapies for patients with diabetes have been revealed to be, in part, a result of an improper extracellular matrix (ECM) environment. In vivo, pancreatic islets are emersed in a diverse ECM that provides physical support