Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy

Autor: Niels Grote Beverborg, Daniela Später, Ralph Knöll, Alejandro Hidalgo, Steve T. Yeh, Zaher Elbeck, Herman H. W. Silljé, Tim R. Eijgenraam, Humam Siga, Magdalena Zurek, Malin Palmér, Susanne Pehrsson, Tamsin Albery, Nils Bomer, Martijn F. Hoes, Cornelis J. Boogerd, Michael Frisk, Eva van Rooij, Sagar Damle, William E. Louch, Qing-Dong Wang, Regina Fritsche-Danielson, Kenneth R. Chien, Kenny M. Hansson, Adam E. Mullick, Rudolf A. de Boer, Peter van der Meer

Publikováno v: Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)

Heart failure is a major cause of morbidity and mortality worldwide. Here the authors show that subcutaneous administration of antisense oligonucleotides targeting PLN is an effective strategy in preclinical models of genetic cardiomyopathy and ische

Externí odkaz: https://doaj.org/article/fe3711b0c9be44609d25d2ed5e1f2344

Cardiac-Specific Overexpression of Oxytocin Receptor Leads to Cardiomyopathy in Mice

Autor: Marcus Franz, Mohammad Bohlooly-Y, Malin Palmér, Michael Lichtenauer, Margareta Elg, Bernhard Wernly, Mikael Bjursell, John Pernow, Frank Seeliger, Christian Jung, Qing-Dong Wang, Therese Admyre, Charlotte Frick, Johannes Wikström, Per-Ove Sjöquist, Ann-Katrin Andersson, John Wiseman

Publikováno v: Journal of Cardiac Failure. 24:470-478

Oxytocin (Oxt) and its receptor (Oxtr) gene system has been implicated in cardiomyogenesis and cardioprotection; however, effects of chronic activation of Oxtr are not known. We generated and investigated transgenic (TG) mice that overexpress Oxtr sp

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a39408d783f14cd34886b574856e0905
https://doi.org/10.1016/j.cardfail.2018.05.004

Evaluation of systemic exposure of nanoparticle suspensions subcutaneously administered to mice regarding stabilization, volume, location, concentration and size

Autor: Kalle Sigfridsson, Malin Palmér

Publikováno v: Drug Development and Industrial Pharmacy. 40:1318-1324

Different routes of administration are likely to result in very different outcomes due to different availability or plasma profile. The objective of the present study was to evaluate the pharmacokinetic profile after different subcutaneous (s.c.) adm

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bd614803da16fd30b80c901df56777d
https://doi.org/10.3109/03639045.2013.817418

Phospholamban antisense oligonucleotides improve cardiac function in murine cardiomyopathy

Autor: Eva van Rooij, H Siga, Alejandro Hidalgo, Susanne Pehrsson, Ralph Knöll, Niels Grote Beverborg, Qing-Dong Wang, Magdalena Zurek, Rudolf A. de Boer, Regina Fritsche-Danielson, Kenny M. Hansson, Michael Frisk, Sagar S. Damle, Adam E. Mullick, Martijn F Hoes, Daniela Später, Tim R Eijgenraam, Kenneth R. Chien, Malin Palmér, Steve T Yeh, Herman H W Silljé, Cornelis J. Boogerd, William E. Louch, Tamsin Albery, Nils Bomer, Peter van der Meer, Zaher Elbeck

Publikováno v: Nature Communications, 12(1). Nature Publishing Group
Nature Communications, 12(1):5180. Nature Publishing Group
Nature Communications, Vol 12, Iss 1, Pp 1-15 (2021)
Nature Communications

Heart failure (HF) is a major cause of morbidity and mortality worldwide, highlighting an urgent need for novel treatment options, despite recent improvements. Aberrant Ca2+ handling is a key feature of HF pathophysiology. Restoring the Ca2+ regulati

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::25b1c61196b5213b6893b0391ecf26eb

In vivo imaging of lipid storage and regression in diet-induced obesity during nutrition manipulation.

Autor: Wahad Bidar, Abdel, Ploj, Karolina, Lelliott, Christopher, Nelander, Karin, Sörhede Winzell, Maria, Böttcher, Gerhard, Oscarsson, Jan, Storlien, Leonard, Hockings, Paul D.

Publikováno v: American Journal of Physiology: Endocrinology & Metabolism; Dec2012, Vol. 303 Issue 11, pE1287-E1295, 9p