Zobrazeno 1 - 6
of 6
pro vyhledávání: '"Malin Graffner-Nordberg"'
Publikováno v:
Chemical and Pharmaceutical Bulletin. 46:591-601
One way to minimise systemic side effects of drugs is to design molecules, soft drugs, in such a way that they are metabolically inactivated rapidly after having acted on their pharmacological target. Hydrolases (esterases, peptidases, lipases, glyco
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8872b9db6aa0ddaee886d2df9474cc15
https://doi.org/10.1248/cpb.46.591
https://doi.org/10.1248/cpb.46.591
Publikováno v:
ChemInform. 29
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0942dc4221d9426c23a2fe79339b7f69
https://doi.org/10.1002/chin.199844097
https://doi.org/10.1002/chin.199844097
Publikováno v:
European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences. 22(1)
A series of dihydrofolate reductase (DHFR) inhibitors, where the methylenamino-bridge of non-classical inhibitors was replaced with an ester function, have been prepared as potential soft drugs intended for inhalation against Pneumocystis carinii pne
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b72af356598418cc95faac7db5b744c
https://pubmed.ncbi.nlm.nih.gov/15113582
https://pubmed.ncbi.nlm.nih.gov/15113582
Publikováno v:
Journal of medicinal chemistry. 46(16)
Crohn's disease is a chronic inflammatory bowel disease characterized by inflammation of both the small and large intestines. Methotrexate (MTX), a classical dihydrofolate reductase (DHFR) inhibitor, has been used as a therapeutic agent in the treatm
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d04d6bba91cee4312e9f1bae69a11967
https://pubmed.ncbi.nlm.nih.gov/12877583
https://pubmed.ncbi.nlm.nih.gov/12877583
Publikováno v:
Journal of medicinal chemistry. 44(15)
A series of lipophilic soft drugs structurally related to the nonclassical dihydrofolate reductase (DHFR) inhibitors trimetrexate and piritrexim have been designed, synthesized, and evaluated in DHFR assays, with special emphasis on the inhibition of
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8e19cd33e46f2c04381a8187ac81d3cc
https://pubmed.ncbi.nlm.nih.gov/11448221
https://pubmed.ncbi.nlm.nih.gov/11448221
Autor:
Göte Swedberg, Anders Hallberg, John Marelius, Asa Persson, Sofie Ohlsson, Paul Andersson, Malin Graffner-Nordberg, Johan Åqvist, Sven Andersson
Publikováno v:
Journal of medicinal chemistry. 43(21)
The relative binding affinities to human dihydrofolate reductase of four new potential antifolates, containing ester linkages between the two aromatic systems, were estimated by free energy perturbation simulations. The ester analogue, predicted to e
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::847d9b500d81c147fc7a43800406fc84
https://pubmed.ncbi.nlm.nih.gov/11052790
https://pubmed.ncbi.nlm.nih.gov/11052790