Zobrazeno 1 - 10
of 90
pro vyhledávání: '"Malin E V Johansson"'
Autor:
Nancy A Erickson, Elisabeth E L Nyström, Lars Mundhenk, Liisa Arike, Rainer Glauben, Markus M Heimesaat, André Fischer, Stefan Bereswill, George M H Birchenough, Achim D Gruber, Malin E V Johansson
Publikováno v:
PLoS ONE, Vol 10, Iss 7, p e0131991 (2015)
The secreted, goblet cell-derived protein Clca1 (chloride channel regulator, calcium-activated-1) has been linked to diseases with mucus overproduction, including asthma and cystic fibrosis. In the intestine Clca1 is found in the mucus with an abunda
Externí odkaz:
https://doaj.org/article/e46b66a46cc24b94baf3b0cade046e49
Autor:
Joakim H Bergström, Katarina A Berg, Ana M Rodríguez-Piñeiro, Bärbel Stecher, Malin E V Johansson, Gunnar C Hansson
Publikováno v:
PLoS ONE, Vol 9, Iss 8, p e104186 (2014)
The MUC2 mucin is the major constituent of the two mucus layers in colon. Mice lacking the disulfide isomerase-like protein Agr2 have been shown to be more susceptible to colon inflammation. The Agr2(-/-) mice have less filled goblet cells and were n
Externí odkaz:
https://doaj.org/article/a32a76d0146a45258a5f10e12b382c2e
Publikováno v:
PLoS ONE, Vol 9, Iss 1, p e85254 (2014)
A functional mucus layer is a key requirement for gastrointestinal health as it serves as a barrier against bacterial invasion and subsequent inflammation. Recent findings suggest that mucus composition may pose an important selection pressure on the
Externí odkaz:
https://doaj.org/article/c964ca8721e04f35801e5e6e34b82316
Autor:
Ulf A Wenzel, Maria K Magnusson, Anna Rydström, Caroline Jonstrand, Julia Hengst, Malin E V Johansson, Anna Velcich, Lena Öhman, Hans Strid, Henrik Sjövall, Gunnar C Hansson, Mary Jo Wick
Publikováno v:
PLoS ONE, Vol 9, Iss 6, p e100217 (2014)
The colonic mucus layer plays a critical role in intestinal homeostasis by limiting contact between luminal bacteria and the mucosal immune system. A defective mucus barrier in animal models allows bacterial contact with the intestinal epithelium and
Externí odkaz:
https://doaj.org/article/30219f5197424d7ba699777a13b458d9
Autor:
Malin E V Johansson
Publikováno v:
PLoS ONE, Vol 7, Iss 7, p e41009 (2012)
The enormous bacterial load and mechanical forces in colon create a special requirement for protection of the epithelium. In the distal colon, this problem is largely solved by separation of the bacteria from the epithelium by a firmly attached inner
Externí odkaz:
https://doaj.org/article/251d78fd615840819446c65725d171e9
Autor:
Malin E V Johansson, Jenny K Gustafsson, Karolina E Sjöberg, Joel Petersson, Lena Holm, Henrik Sjövall, Gunnar C Hansson
Publikováno v:
PLoS ONE, Vol 5, Iss 8, p e12238 (2010)
Protection of the large intestine with its enormous amount of commensal bacteria is a challenge that became easier to understand when we recently could describe that colon has an inner attached mucus layer devoid of bacteria (Johansson et al. (2008)
Externí odkaz:
https://doaj.org/article/b1ab0eda17374208bad57fca2e57b903
Autor:
Pablo Gallego, Maria-Jose Garcia-Bonete, Sergio Trillo-Muyo, Christian V. Recktenwald, Malin E. V. Johansson, Gunnar C. Hansson
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-9 (2023)
The MUC2 mucin is a large, highly glycosylated polymer that builds the intestinal mucus. Here, the authors generate a high-resolution structural model of the 800 amino acid C-terminal dimer including its glycans. Stabilization is achieved by interdim
Externí odkaz:
https://doaj.org/article/9ee9726a35af4a11b7c5bc17fa87abe1
Autor:
Brendan, Dolan, Anna, Ermund, Beatriz, Martinez-Abad, Malin E V, Johansson, Gunnar C, Hansson
Publikováno v:
Science signaling. 15(752)
Goblet cells in the small intestinal crypts contain large numbers of mucin granules that are rapidly discharged to clean bacteria from the crypt. Because acetylcholine released by neuronal and nonneuronal cells controls many aspects of intestinal epi
Publikováno v:
Nature Reviews Gastroenterology & Hepatology. 19:785-803
Autor:
Jack D. A. Sharpen, Brendan Dolan, Elisabeth E. L. Nyström, George M. H. Birchenough, Liisa Arike, Beatriz Martinez-Abad, Malin E. V. Johansson, Gunnar C. Hansson, Christian V. Recktenwald
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-12 (2022)
Nature Communications
Nature Communications
The colonic mucus layer is organized as a two-layered system providing a physical barrier against pathogens and simultaneously harboring the commensal flora. The factors contributing to the organization of this gel network are not well understood. In