Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Malin Degerman-Gunnarsson"'
Autor:
RoseMarie Brundin, Malin Degerman Gunnarsson, Julia Remnestål, Lena Kilander, Peter Nilsson, Henrik Zetterberg, Payam Emami Khoonsari, Stephanie Herman, Kim Kultima, Ganna Shevchenko, Martin Ingelsson, Vilmantas Giedraitis, Lars Lannfelt
Publikováno v:
Journal of Alzheimer's Disease
Background Alzheimer's disease (AD) is diagnosed based on a clinical evaluation as well as analyses of classical biomarkers: Aβ42, total tau (t-tau), and phosphorylated tau (p-tau) in cerebrospinal fluid (CSF). Although the sensitivities and specifi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bad94df125456b7b4023fc8708686089
https://pubmed.ncbi.nlm.nih.gov/30614806
https://pubmed.ncbi.nlm.nih.gov/30614806
Autor:
Malin Degerman Gunnarsson, Lena Kilander, Lars Lannfelt, Hans Basun, Martin Ingelsson, Kaj Blennow
Publikováno v:
Alzheimer's Research & Therapy
Background Increased concentrations of cerebrospinal fluid (CSF) total tau (t-tau) and phosphorylated tau, as well as decreased amyloid-β 42 peptide, are biomarkers of Alzheimer’s disease (AD) pathology, but few studies have shown an association w
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1ce77e0a8c0eb3aa297c319aeb5ef639
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-298845
http://urn.kb.se/resolve?urn=urn:nbn:se:uu:diva-298845
Autor:
Anja Harmeier, Sathish Kumar, Lars Lannfelt, Christian Erck, Henrik Martens, Oliver Wirths, Constanze Geumann, Gerd Multhaup, Sadim Jawhar, Hannu Kalimo, Martin Ingelsson, Thomas A. Bayer, Jochen Walter, Inge Huitinga, Malin Degerman-Gunnarsson
Publikováno v:
Journal of Biological Chemistry. 285:41517-41524
N-terminally truncated Aβ peptides starting with pyroglutamate (AβpE3) represent a major fraction of all Aβ peptides in the brain of Alzheimer disease (AD) patients. AβpE3 has a higher aggregation propensity and stability and shows increased toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c679dbe6880b8de821fe19b194b7e8d
https://doi.org/10.1074/jbc.m110.178707
https://doi.org/10.1074/jbc.m110.178707
Autor:
Vilmantas Giedraitis, Malin Degerman-Gunnarsson, Martin Ingelsson, Anders Larsson, Lena Kilander, Hans Basun, Maria Eriksdotter-Jönhagen, Lennart Minthon, Lars Lannfelt, Johan Sundelöf, Oskar Hansson, Kaj Blennow, Johan Sundström
Publikováno v:
Journal of Alzheimer's Disease. 21:471-478
Cystatin C is suggested to be involved in neurodegeneration and the development of Alzheimer's disease (AD) by binding to soluble amyloid-beta (Abeta) peptides. Studies of cystatin C levels in cerebrospinal fluid (CSF) in relation to risk of AD are c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0162f07355636e515e9cd21275d40567
https://doi.org/10.3233/jad-2010-091594
https://doi.org/10.3233/jad-2010-091594
Autor:
Hans Basun, Lena Kilander, Anders Larsson, Elina Rönnemaa, Malin Degerman-Gunnarsson, Johan Sundelöf, Johanna Helmersson, Lars Lannfelt, Samar Basu
Publikováno v:
Journal of Alzheimer's Disease. 18:79-87
Inflammation is suggested to be involved in the pathogenesis of Alzheimer's disease (AD). Serum interleukin-6 (IL-6) and high sensitivity serum reactive protein C (hsCRP) as markers of systemic inflammation were analyzed at two examinations of the UL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d86cb8dc419adae105a9c61959b49dfb
https://doi.org/10.3233/jad-2009-1126
https://doi.org/10.3233/jad-2009-1126
Autor:
Lars Lannfelt, Hillevi Englund, Marie Hedlund, Lena Kilander, Frida Ekholm Pettersson, Malin Degerman Gunnarsson, Rose Marie Brundin
Publikováno v:
Neurodegenerative Diseases. 6:139-147
Background/Objective: The lowering of natively analyzed Aβ42 in cerebrospinal fluid (CSF) is used as a diagnostic tool in Alzheimer’s disease (AD). The presence of Aβ oligomers can interfere with such analyses causing underestimation of Aβ level
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0a0473b6e2db731e6374f752f6bafa8
https://doi.org/10.1159/000225376
https://doi.org/10.1159/000225376
Autor:
Björn Zethelius, Johan Sundelöf, Johan Sundström, Malin Degerman-Gunnarsson, Lena Kilander, Elina Rönnemaa, Lars Lannfelt, Christian Berne
Publikováno v:
Neurology. 71:1065-1071
Subjects with diabetes are reported to have an increased risk of dementia and cognitive impairment. However, the underlying causes remain unknown. We investigated the longitudinal associations between midlife insulin secretion, glucose metabolism, an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::57cf25ac2d3cade8899acb91a59b546e
https://doi.org/10.1212/01.wnl.0000310646.32212.3a
https://doi.org/10.1212/01.wnl.0000310646.32212.3a
Autor:
Tuula Pirttilä, Vilmantas Giedraitis, Anna Glaser, Mikko Hiltunen, Lars Lannfelt, Martin Ingelsson, Hilkka Soininen, Malin Degerman Gunnarsson, Lena Kilander, RoseMarie Brundin, Timo Sarajärvi, Lars Bertram, Brit-Maren M. Schjeide, Seppo Helisalmi, Rudolph E. Tanzi
Publikováno v:
Neuroscience Letters. 469:265-267
Recently, the P86L alteration in CALHM1 (calcium homeostasis modulator-1) was reported to be associated with Alzheimer's disease (AD). Moreover, the risk allele increased amyloid-beta (A beta) levels in conditioned media from cultured cells. Therefor
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7721befa1aa9db06818f2b70349614ca
https://doi.org/10.1016/j.neulet.2009.12.011
https://doi.org/10.1016/j.neulet.2009.12.011
Autor:
Oliver, Wirths, Christian, Erck, Henrik, Martens, Anja, Harmeier, Constanze, Geumann, Sadim, Jawhar, Sathish, Kumar, Gerd, Multhaup, Jochen, Walter, Martin, Ingelsson, Malin, Degerman-Gunnarsson, Hannu, Kalimo, Inge, Huitinga, Lars, Lannfelt, Thomas A, Bayer
Publikováno v:
The Journal of biological chemistry. 285(53)
N-terminally truncated Aβ peptides starting with pyroglutamate (AβpE3) represent a major fraction of all Aβ peptides in the brain of Alzheimer disease (AD) patients. AβpE3 has a higher aggregation propensity and stability and shows increased toxi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::f6a861d1d28cc57d88b63f59362b4bc1
https://pubmed.ncbi.nlm.nih.gov/20971852
https://pubmed.ncbi.nlm.nih.gov/20971852
Autor:
Anders Larsson, Maria Eriksdotter-Jönhagen, Malin Degerman-Gunnarsson, Oskar Hansson, Lars Lannfelt, Johan Sundelöf, Hans Basun, Kaj Blennow, Lena Kilander, Vilmantas Giedraitis, Lennart Minthon, Martin Ingelsson, Johan Sundström
Publikováno v:
Journal of Alzheimer's disease : JAD. 22(4)
Cathepsin B is suggested to be involved in amyloid-β (Aβ) processing and Alzheimer's disease (AD). Studies of cathepsin B levels in plasma and cerebrospinal fluid (CSF) have not been previously performed. We examined cathepsin B levels in plasma an
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3db05ed45116e21c40861f8cfca11ac0
https://pubmed.ncbi.nlm.nih.gov/20930303
https://pubmed.ncbi.nlm.nih.gov/20930303