Zobrazeno 1 - 10
of 29
pro vyhledávání: '"Malika, Hale"'
Autor:
Brenda J. Seymour, Swati Singh, Hannah M. Certo, Karen Sommer, Blythe D. Sather, Socheath Khim, Courtnee Clough, Malika Hale, Joseph Pangallo, Byoung Y. Ryu, Iram F. Khan, Jennifer E. Adair, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 20, Iss , Pp 635-651 (2021)
X-linked agammaglobulinemia (XLA) is an immune disorder caused by mutations in Bruton’s tyrosine kinase (BTK). BTK is expressed in B and myeloid cells, and its deficiency results in a lack of mature B cells and protective antibodies. We previously
Externí odkaz:
https://doaj.org/article/4469c8d686fc425a84ca48e687ffdce5
Autor:
Linhui Hao, Tien-Ying Hsiang, Ronit R. Dalmat, Renee Ireton, Jennifer F. Morton, Caleb Stokes, Jason Netland, Malika Hale, Chris Thouvenel, Anna Wald, Nicholas M. Franko, Kristen Huden, Helen Y. Chu, Alex Sigal, Alex L. Greninger, Sasha Tilles, Lynn K. Barrett, Wesley C. Van Voorhis, Jennifer Munt, Trevor Scobey, Ralph S. Baric, David J. Rawlings, Marion Pepper, Paul K. Drain, Michael Gale
Publikováno v:
Viruses, Vol 15, Iss 2, p 530 (2023)
New variants of SARS-CoV-2 continue to emerge and evade immunity. We isolated SARS-CoV-2 temporally across the pandemic starting with the first emergence of the virus in the western hemisphere and evaluated the immune escape among variants. A clinic-
Externí odkaz:
https://doaj.org/article/fdaa1f3636174da08d27e757b88a435b
Autor:
Malika Hale, Baeckseung Lee, Yuchi Honaker, Wai-Hang Leung, Alexandra E. Grier, Holly M. Jacobs, Karen Sommer, Jaya Sahni, Shaun W. Jackson, Andrew M. Scharenberg, Alexander Astrakhan, David J. Rawlings
Publikováno v:
Molecular Therapy: Methods & Clinical Development, Vol 4, Iss C, Pp 192-203 (2017)
Gene editing by homology-directed recombination (HDR) can be used to couple delivery of a therapeutic gene cassette with targeted genomic modifications to generate engineered human T cells with clinically useful profiles. Here, we explore the functio
Externí odkaz:
https://doaj.org/article/5c8a965f6c324b0c809e18b4b234bc06
Autor:
Jacquelyn A. Gorman, Christian Hundhausen, Mackenzie Kinsman, Tanvi Arkatkar, Eric J. Allenspach, Courtnee Clough, Samuel E. West, Kerri Thomas, Ahmet Eken, Socheath Khim, Malika Hale, Mohamed Oukka, Shaun W. Jackson, Karen Cerosaletti, Jane H. Buckner, David J. Rawlings
Publikováno v:
Frontiers in Immunology, Vol 10 (2019)
TYK2 is a JAK family member that functions downstream of multiple cytokine receptors. Genome wide association studies have linked a SNP (rs34536443) within TYK2 encoding a Proline to Alanine substitution at amino acid 1104, to protection from multipl
Externí odkaz:
https://doaj.org/article/55651875f75548a480ec57f33ff5b7cf
Autor:
Malika Hale, Jason Netland, Yu Chen, Christopher D. Thouvenel, Katherine Nabel Smith, Lucille M. Rich, Elizabeth R. Vanderwall, Marcos C. Miranda, Julie Eggenberger, Linhui Hao, Michael J. Watson, Charles C. Mundorff, Lauren B. Rodda, Neil P. King, Miklos Guttman, Michael Gale, Jonathan Abraham, Jason S. Debley, Marion Pepper, David J. Rawlings
Publikováno v:
Journal of Experimental Medicine. 219
Autor:
Linhui Hao, Tien-Ying Hsiang, Ronit R. Dalmat, Renee Ireton, Jennifer Morton, Caleb Stokes, Jason Netland, Malika Hale, Chris Thouvenel, Anna Wald, Nicholas M Franko, Kristen Huden, Helen Chu, Alex Greninger, Sasha Tilles, Lynn K. Barrett, Wesley C. Van Voorhis, Jennifer Munt, Trevor Scobey, Ralph S. Baric, David Rawlings, Marion Pepper, Paul K. Drain, Michael Gale
Publikováno v:
medRxiv
To evaluate SARS-CoV-2 variants we isolated SARS-CoV-2 temporally during the pandemic starting with first appearance of virus in the Western hemisphere near Seattle, WA, USA, and isolated each known major variant class, revealing the dynamics of emer
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bdd202273c917eafc30ea1c6824c6ee4
https://doi.org/10.1101/2022.08.12.22278720
https://doi.org/10.1101/2022.08.12.22278720
Autor:
Malika Hale, Jason Netland, Yu Chen, Christopher D. Thouvenel, Katherine Nabel Smith, Lucille M. Rich, Elizabeth R. Vanderwall, Marcos C. Miranda, Julie Eggenberger, Linhui Hao, Michael J. Watson, Charles C. Mundorff, Lauren B. Rodda, Neil P. King, Miklos Guttman, Michael Gale, Jonathan Abraham, Jason S. Debley, Marion Pepper, David J. Rawlings
Publikováno v:
The Journal of experimental medicine. 219(9)
Humoral immunity to SARS-CoV-2 can be supplemented with polyclonal sera from convalescent donors or an engineered monoclonal antibody (mAb) product. While pentameric IgM antibodies are responsible for much of convalescent sera’s neutralizing capaci
Autor:
Lauren B. Rodda, Peter A. Morawski, Kurt B. Pruner, Mitchell L Fahning, Christian A. Howard, Nicholas Franko, Jennifer Logue, Julie Eggenberger, Caleb Stokes, Inah Golez, Malika Hale, Michael Gale, Helen Y. Chu, Daniel J. Campbell, Marion Pepper
SummaryImmune memory is tailored by cues that lymphocytes perceive during priming. The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) pandemic created a situation in which nascent memory could be tracked through additional antigen expos
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::50c29b3ef85a2159e96524909932bc24
https://doi.org/10.1101/2022.01.12.22269192
https://doi.org/10.1101/2022.01.12.22269192
Autor:
Guillermo S Romano Ibarra, Biswajit Paul, Blythe D Sather, Patrick M Younan, Karen Sommer, John P Kowalski, Malika Hale, Barry Stoddard, Jordan Jarjour, Alexander Astrakhan, Hans-Peter Kiem, David J Rawlings
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 5, Iss C (2016)
A naturally occurring 32-base pair deletion of the HIV-1 co-receptor CCR5 has demonstrated protection against HIV infection of human CD4+ T cells. Recent genetic engineering approaches using engineered nucleases to disrupt the gene and mimic this mut
Externí odkaz:
https://doaj.org/article/9a753dd3c9794ca9b239d6c43c9c7b98
Autor:
Malika Hale, Calvin Le, Troy Yi, Lue Ping Zhao, Thomas H. Payne, John E Brimm, Alex Kostrinsky-Thomas, Duncan Hussey, Fuki M. Hisama, Peter Wilcox, Jesse C Hinshaw
Publikováno v:
Journal of the American Medical Informatics Association : JAMIA
Objective The genetic testing for hereditary breast cancer that is most helpful in high-risk women is underused. Our objective was to quantify the risk factors for heritable breast and ovarian cancer contained in the electronic health record (EHR), t