Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Malik Lutzmann"'
Autor:
Angélique Bruyer, Laure Dutrieux, Hugues de Boussac, Thibaut Martin, Djamila Chemlal, Nicolas Robert, Guilhem Requirand, Guillaume Cartron, Laure Vincent, Charles Herbaux, Malik Lutzmann, Caroline Bret, Philippe Pasero, Jérôme Moreaux, Sara Ovejero
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
Multiple myeloma (MM) is a hematological malignancy characterized by an abnormal clonal proliferation of malignant plasma cells. Despite the introduction of novel agents that have significantly improved clinical outcome, most patients relapse and dev
Externí odkaz:
https://doaj.org/article/5f646fda97b9447783fcecabae90b4cd
Autor:
Malik Lutzmann, Florence Bernex, Cindy da Costa de Jesus, Dana Hodroj, Caroline Marty, Isabelle Plo, William Vainchenker, Marie Tosolini, Luc Forichon, Caroline Bret, Sophie Queille, Candice Marchive, Jean-Sébastien Hoffmann, Marcel Méchali
Publikováno v:
Cell Reports, Vol 28, Iss 11, Pp 2851-2865.e4 (2019)
Summary: Hematopoiesis is particularly sensitive to DNA damage. Myeloid tumor incidence increases in patients with DNA repair defects and after chemotherapy. It is not known why hematopoietic cells are highly vulnerable to DNA damage. Addressing this
Externí odkaz:
https://doaj.org/article/1b5c45032647429590e52fb8e732a408
Autor:
Guillaume Labrousse, Pierre Vande Perre, Genis Parra, Marion Jaffrelot, Laura Leroy, Frederic Chibon, Frederic Escudie, Janick Selves, Jean-Sebastien Hoffmann, Rosine Guimbaud, Malik Lutzmann
Publikováno v:
NAR Cancer. 5
The exonuclease domain of DNA polymerases epsilon's catalytic subunit (POLE) removes misincorporated nucleotides, called proofreading. POLE-exonuclease mutations cause colorectal- and endometrial cancers with an extreme burden of single nucleotide su
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f762d3fdfc4c84e011c3eeaa084cf5bd
https://doi.org/10.1093/narcan/zcad011
https://doi.org/10.1093/narcan/zcad011
Autor:
Valérie Bergoglio, Jean-Sébastien Hoffmann, A. Névot, S. Elkaoutari, Louis Buscail, N. Bery, C. Lopez, Nelson Dusetti, Malik Lutzmann, Vera Pancaldi, G. Labrousse, A. Lumeau, Pierre Cordelier, Marie-Jeanne Pillaire, M. Gayral, Miguel Madrid-Mencía, A. Frances, Cyril Ribeyre
Chronic DNA replication stress and genome instability are two hallmarks of cancer that fuel oncogenesis and tumor diversity. Therapeutic approaches aimed to leverage tumor-specific replication stress to intolerable levels or to expose vulnerabilities
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9267ad2570dde0dd8cc32cda4089b31d
https://hal.archives-ouvertes.fr/hal-03409378/file/2021.10.23.465566v1.full.pdf
https://hal.archives-ouvertes.fr/hal-03409378/file/2021.10.23.465566v1.full.pdf
Autor:
Raphaël Rodriguez, Jérôme Moreaux, Yea-Lih Lin, Philippe Pasero, Malik Lutzmann, Laure Dutrieux, Michel Cogné
Publikováno v:
Cancers, Vol 13, Iss 3755, p 3755 (2021)
Cancers
Cancers, MDPI, 2021, 13 (15), pp.3755. ⟨10.3390/cancers13153755⟩
Cancers, 2021, 13 (15), pp.3755. ⟨10.3390/cancers13153755⟩
Cancers
Cancers, MDPI, 2021, 13 (15), pp.3755. ⟨10.3390/cancers13153755⟩
Cancers, 2021, 13 (15), pp.3755. ⟨10.3390/cancers13153755⟩
Simple Summary Multiple myeloma is a hematologic cancer characterized by the accumulation of malignant plasma cells in the bone marrow. It remains a mostly incurable disease due to the inability to overcome refractory disease and drug-resistant relap
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba2f33f953c7851fcbade7409cc6ea13
https://www.mdpi.com/2072-6694/13/15/3755
https://www.mdpi.com/2072-6694/13/15/3755
Autor:
Olivier Ganier, Marcel Méchali, Sihem Zitouni, Isabelle Peiffer, Malik Lutzmann, Julien Cau, Céline Lemmers, Charles Theillet
SUMMARYDNA replication initiates with pre-replication complex (pre-RC) formation at replication origins in G1 (replication origin licensing), followed by activation of a pre-RC subset in the S phase. It has been suggested that a checkpoint prevents S
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::44897e45032266af8446d69de55afb17
https://doi.org/10.1101/2020.07.08.193607
https://doi.org/10.1101/2020.07.08.193607
Autor:
Malik Lutzmann, Valérie Bergoglio, Nicolas Bery, Samad Elkaoutari, Louis Buscail, Marie-Jeanne Pillaire, Miguel Madrid-Mencía, Pierre Cordelier, Jean-Sébastien Hoffmann, Vera Pancaldi, Cyril Ribeyre, Guillaume Labrousse, Nelson Dusseti, Audrey Lumeau
Publikováno v:
Cancer Research. 81:PO-043
Cytidine deaminase (CDA) converts cytidine and deoxycytidine into uridine and deoxyuridine within the pyrimidine salvage pathway for DNA and RNA synthesis. In this regard, loss of CDA provokes genomic instability in Bloom Syndrome, and CDA overexpres
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0739d9da739914fdd44f34a0a3efbabc
https://doi.org/10.1158/1538-7445.panca21-po-043
https://doi.org/10.1158/1538-7445.panca21-po-043
Autor:
Philippe Pasero, Malik Lutzmann, Nicolas Robert, Laure Dutrieux, Guilhem Requirand, Yea-Lih Lin, Michel Cogné, Charles Herbaux, Guillaume Cartron, Jérôme Moreaux, Laure Vincent, Raphaël Rodriguez
Publikováno v:
Blood. 138:1582-1582
Multiple myeloma (MM) is the second most frequent hematological malignancy, characterized by the accumulation of malignant plasma cells (PCs) within the bone marrow. To date, there is no definitive treatment for this pathology and a majority of patie
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8bc1e6b3e021c7ec224dda130df94d74
https://doi.org/10.1182/blood-2021-151530
https://doi.org/10.1182/blood-2021-151530
Autor:
Cyril Ribeyre, Pierre Cordelier, Marie-Jeanne Pillaire, Louis Buscail, Miguel Madrid-Mencía, Malik Lutzmann, Jérôme Torrisani, A. Lumeau, Valérie Bergoglio, A. Frances, Jean-Sébastien Hoffmann
Publikováno v:
Pancreatology. 20:S41-S42
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::5b35362d3cda282204ab898a313fd45d
https://doi.org/10.1016/j.pan.2020.07.054
https://doi.org/10.1016/j.pan.2020.07.054
Autor:
Jean-Sébastien Hoffmann, Marie Tosolini, Cindy da Costa de Jesus, Malik Lutzmann, Caroline Marty, Dana Hodroj, Candice Marchive, Marcel Méchali, Caroline Bret, William Vainchenker, Isabelle Plo, Luc Forichon, Florence Bernex, Sophie Queille
Publikováno v:
Cell Reports
Cell Reports, 2019, 28 (11), pp.2851-2865. ⟨10.1016/j.celrep.2019.07.095⟩
Cell Reports, Elsevier Inc, 2019, 28 (11), pp.2851-2865. ⟨10.1016/j.celrep.2019.07.095⟩
Cell Reports, Vol 28, Iss 11, Pp 2851-2865.e4 (2019)
Cell Reports, 2019, 28 (11), pp.2851-2865. ⟨10.1016/j.celrep.2019.07.095⟩
Cell Reports, Elsevier Inc, 2019, 28 (11), pp.2851-2865. ⟨10.1016/j.celrep.2019.07.095⟩
Cell Reports, Vol 28, Iss 11, Pp 2851-2865.e4 (2019)
Summary: Hematopoiesis is particularly sensitive to DNA damage. Myeloid tumor incidence increases in patients with DNA repair defects and after chemotherapy. It is not known why hematopoietic cells are highly vulnerable to DNA damage. Addressing this
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::366bfa15cc97041ac2ba3ff5538324ad
https://doi.org/10.1016/j.celrep.2019.07.095
https://doi.org/10.1016/j.celrep.2019.07.095