Zobrazeno 1 - 10
of 18
pro vyhledávání: '"Malik Kahli"'
Autor:
Nataliya Petryk, Malik Kahli, Yves d'Aubenton-Carafa, Yan Jaszczyszyn, Yimin Shen, Maud Silvain, Claude Thermes, Chun-Long Chen, Olivier Hyrien
Publikováno v:
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
The physical origin and termination sites of DNA replication in human cells have remained elusive. Here the authors use Okazaki fragment sequencing to reveal global replication patterns and show how chromatin and transcription modulate the process.
Externí odkaz:
https://doaj.org/article/33be268cd5f4463da7c86414495060a0
Autor:
Rasha E Boulos, Hanna Julienne, Antoine Baker, Chun-Long Chen, Nataliya Petryk, Malik Kahli, Yves dʼAubenton-Carafa, Arach Goldar, Pablo Jensen, Olivier Hyrien, Claude Thermes, Alain Arneodo, Benjamin Audit
Publikováno v:
New Journal of Physics, Vol 16, Iss 11, p 115014 (2014)
The three-dimensional (3D) architecture of the mammalian nucleus is now being unraveled thanks to the recent development of chromatin conformation capture (3C) technologies. Here we report the results of a combined multiscale analysis of genome-wide
Externí odkaz:
https://doaj.org/article/3ed0d573f58941df8c1abbd23de9bee4
Autor:
Peter Tonzi, Malik Kahli, Tony T. Huang, Duncan J. Smith, Sarah Keegan, David Fenyö, Yu Hung Chen
Publikováno v:
Nature structural & molecular biology
Although DNA replication is a fundamental aspect of biology, it is not known what determines where DNA replication starts and stops in the human genome. Here we directly identify and quantitatively compare sites of replication initiation and terminat
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::05b0fcc97983603a0ace28705eadb467
https://doi.org/10.1038/s41594-018-0171-0
https://doi.org/10.1038/s41594-018-0171-0
Publikováno v:
Nucleic Acids Research
Prior to ligation, each Okazaki fragment synthesized on the lagging strand in eukaryotes must be nucleolytically processed. Nuclease cleavage takes place in the context of 5’ flap structures generated via strand-displacement synthesis by DNA polyme
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20f47dfe86b9c5c554ce1cffcd37831c
https://doi.org/10.1093/nar/gky1242
https://doi.org/10.1093/nar/gky1242
Autor:
Malik Kahli, Kate E. Coleman, Peter Tonzi, Noor Chalhoub, Sarah Keegan, Yu Hung Chen, Tony T. Huang, Sarah Kit Leng Lui, Duncan J. Smith, David Fenyö
Publikováno v:
Nat Protoc
The ability to monitor DNA replication fork directionality at the genome-wide scale is paramount for a greater understanding of how genetic and environmental perturbations can impact replication dynamics in human cells. Here, we describe a detailed p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f8e4d4d2d3c8f78cf60fefdbac16c07
https://pubmed.ncbi.nlm.nih.gov/33442052
https://pubmed.ncbi.nlm.nih.gov/33442052
Autor:
Malik Kahli, Duncan J. Smith, Peter Tonzi, David Fenyö, Tony T. Huang, Sarah Keegan, Yu Hung Chen
The locations of active DNA replication origins in the human genome, and the determinants of origin activation, remain controversial. Additionally, neither the predominant sites of replication termination nor the impact of transcription on replicatio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a71e168b8a0cb2fa2744496dfa921f7e
https://doi.org/10.1101/324079
https://doi.org/10.1101/324079
Autor:
Benjamin Audit, Véronique Maguer-Satta, Frank-Emmanuel Nicolini, Yan Jaszczyszyn, Xia Wu, Françoise Argoul, Bastien Laperrousaz, Olivier Hyrien, Ruohong Xia, Malik Kahli, Cédric Fund, Alain Arneodo, Guénola Drillon, Hadi Kabalane, Frédéric Chibon, Nataliya Petryk, Aude Robert, Joëlle Wiels, Gaëlle Pérot
Publikováno v:
Nucleic Acids Research
Nucleic Acids Research, Oxford University Press, 2018, 46 (19), pp.10157-10172. ⟨10.1093/nar/gky797⟩
Nucleic Acids Research, 2018, 46 (19), pp.10157-10172. ⟨10.1093/nar/gky797⟩
Nucleic Acids Research, Oxford University Press, 2018, 46 (19), pp.10157-10172. ⟨10.1093/nar/gky797⟩
Nucleic Acids Research, 2018, 46 (19), pp.10157-10172. ⟨10.1093/nar/gky797⟩
International audience; The spatiotemporal program of metazoan DNA repli-cation is regulated during development and altered in cancers. We have generated novel OK-seq, Repli-seq and RNA-seq data to compare the DNA replica-tion and gene expression pro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::932823ed87c87f3837028ea209b48ca0
https://hal.archives-ouvertes.fr/hal-01910890
https://hal.archives-ouvertes.fr/hal-01910890
Autor:
Benjamin Audit, Olivier Hyrien, Françoise Argoul, Malik Kahli, Nataliya Petryk, Arach Goldar, Aurélien Rappailles, Guillaume Guilbaud, Alain Arneodo
Publikováno v:
Scientific Reports
Scientific Reports, 2016, 6 (22), pp.22469 (1-8). ⟨10.1038/srep22469⟩
Scientific Reports, Nature Publishing Group, 2016, 6 (22), pp.22469 (1-8). ⟨10.1038/srep22469⟩
Scientific Reports, Nature Publishing Group, 2016, 6 (22), pp.22469 (1-8). 〈10.1038/srep22469〉
Goldar, A, Arneodo, A, Audit, B, Argoul, F, Rappailles, A, Guilbaud, G, Petryk, N, Kahli, M & Hyrien, O 2016, ' Deciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations ', Scientific Reports, vol. 6, 22469 . https://doi.org/10.1038/srep22469
Scientific Reports, 2016, 6 (22), pp.22469 (1-8). ⟨10.1038/srep22469⟩
Scientific Reports, Nature Publishing Group, 2016, 6 (22), pp.22469 (1-8). ⟨10.1038/srep22469⟩
Scientific Reports, Nature Publishing Group, 2016, 6 (22), pp.22469 (1-8). 〈10.1038/srep22469〉
Goldar, A, Arneodo, A, Audit, B, Argoul, F, Rappailles, A, Guilbaud, G, Petryk, N, Kahli, M & Hyrien, O 2016, ' Deciphering DNA replication dynamics in eukaryotic cell populations in relation with their averaged chromatin conformations ', Scientific Reports, vol. 6, 22469 . https://doi.org/10.1038/srep22469
We propose a non-local model of DNA replication that takes into account the observed uncertainty on the position and time of replication initiation in eukaryote cell populations. By picturing replication initiation as a two-state system and consideri
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0feaf0cea4113ffc5db4df378ff4c529
https://hal.science/hal-01412574/file/GoldarSRep2016.pdf
https://hal.science/hal-01412574/file/GoldarSRep2016.pdf
Autor:
Maud Silvain, Olivier Hyrien, Claude Thermes, Chun-Long Chen, Yimin Shen, Yan Jaszczyszyn, Malik Kahli, Nataliya Petryk, Yves d'Aubenton-Carafa
Publikováno v:
Nature Communications
Nature Communications, 2016, 7, ⟨10.1038/ncomms10208⟩
Nature Communications, Nature Publishing Group, 2016, 7, 〈10.1038/ncomms10208〉
Nature Communications, Nature Publishing Group, 2016, 7, ⟨10.1038/ncomms10208⟩
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Nature Communications, 2016, 7, ⟨10.1038/ncomms10208⟩
Nature Communications, Nature Publishing Group, 2016, 7, 〈10.1038/ncomms10208〉
Nature Communications, Nature Publishing Group, 2016, 7, ⟨10.1038/ncomms10208⟩
Nature Communications, Vol 7, Iss 1, Pp 1-13 (2016)
Despite intense investigation, human replication origins and termini remain elusive. Existing data have shown strong discrepancies. Here we sequenced highly purified Okazaki fragments from two cell types and, for the first time, quantitated replicati
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd1786d6df0b76e5357a169d19088ca9
https://hal.science/hal-01412672/file/PKJS.pdf
https://hal.science/hal-01412672/file/PKJS.pdf
Autor:
Romain Desprat, Emilie Besnard, Malik Kahli, Jean-Marc Lemaitre, Mirit I. Aladjem, Haiqing Fu, Michael T. Ryan
Publikováno v:
Current Protocols in Cell Biology
Current Protocols in Cell Biology, 2014, 65 (1), pp.22.20.1-22.20.17. ⟨10.1002/0471143030.cb2220s65⟩
Current Protocols in Cell Biology, Wiley, 2014, 65 (1), pp.22.20.1-22.20.17. ⟨10.1002/0471143030.cb2220s65⟩
Current Protocols in Cell Biology, 2014, 65 (1), pp.22.20.1-22.20.17. ⟨10.1002/0471143030.cb2220s65⟩
Current Protocols in Cell Biology, Wiley, 2014, 65 (1), pp.22.20.1-22.20.17. ⟨10.1002/0471143030.cb2220s65⟩
International audience; Recent advances in genome-sequencing technology have led to the complete mapping of DNA replication initiation sites in the human genome. This thorough origin mapping facilitates understanding of the relationship between repli
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::52805c01e552fb52878202f004d77b86
https://hal.umontpellier.fr/hal-01840235/document
https://hal.umontpellier.fr/hal-01840235/document