Synthesis, characterization, in-silico, and pharmacological evaluation of new 2-amino-6‑trifluoromethoxy benzothiazole derivatives

Autor: Malik, Sumra, Miana, G.A, Ata, Athar, Kanwal, Madiha, Maqsood, Saima, Malik, Imran, Kazmi, Zartashia

Publikováno v: In Bioorganic Chemistry January 2023 130

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Pyrazolone-nicotinic acid derivative (4Z)-4-(2-hydroxybenzylidine)-5-methyl-2-(pyridine-3-ylcarbonyl)-2, 4-dihydro-3H-pyrazole-3-one (IIc) as multitarget inhibitor of neurodegeneration and behavioural impairment in Dementia.

Autor: Kanwal M; Department of Pharmaceutical Chemistry, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan., Sarwar S; Cell Culture Lab, Department of Pharmacognosy, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan., Nadeem H; Department of Pharmaceutical Chemistry, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan., Alghamdi SA; Department of Medical Laboratory, College of Applied Medical Sciences, Prince Sattam Bin Abdulaziz University, Al-Kharj 11942, Saudi Arabia., Alamro AA; Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia., Malik S; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan., Maqsood S; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan., Alghamdi AA; Department of Biochemistry, College of Science, King Saud University, Riyadh, Saudi Arabia., Tariq MJ; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan., Malik I; Department of Pharmaceutical Chemistry, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan., Khan AU; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan., Muskan A; Department of Pharmacology, Riphah Institute of Pharmaceutical Sciences, Riphah International University, Islamabad 44000, Pakistan.

Publikováno v: The Journal of pharmacy and pharmacology [J Pharm Pharmacol] 2024 Oct 14. Date of Electronic Publication: 2024 Oct 14.