Zobrazeno 1 - 10
of 234
pro vyhledávání: '"Malik, Alawi"'
Publikováno v:
Genetics and Molecular Biology, Vol 47, Iss 2 (2024)
Abstract Growth differentiation factor 11 (GDF11) and myostatin (MSTN/GDF8) are closely related members of the transforming growth factor β (TGFβ) superfamily, sharing structural homology. Despite these structural similarities, recent research has
Externí odkaz:
https://doaj.org/article/788ba200791344ccb4f46ea9ecc402a1
Autor:
Lutgardis Bergmann, Simone Balzer Le, Gunhild Hageskal, Lena Preuss, Yuchen Han, Yekaterina Astafyeva, Simon Loevenich, Sarah Emmann, Pablo Perez-Garcia, Daniela Indenbirken, Elena Katzowitsch, Fritz Thümmler, Malik Alawi, Alexander Wentzel, Wolfgang R. Streit, Ines Krohn
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract Biofilms are resistant to many traditional antibiotics, which has led to search for new antimicrobials from different and unique sources. To harness the potential of aquatic microbial resources, we analyzed the meta-omics datasets of microal
Externí odkaz:
https://doaj.org/article/125c69deb1d84b769a42854625b63aba
Autor:
Swantje Thiele, Stephanie Stanelle-Bertram, Sebastian Beck, Nancy Mounogou Kouassi, Martin Zickler, Martin Müller, Berfin Tuku, Patricia Resa-Infante, Debby van Riel, Malik Alawi, Thomas Günther, Franziska Rother, Stefanie Hügel, Susanne Reimering, Alice McHardy, Adam Grundhoff, Wolfram Brune, Albert Osterhaus, Michael Bader, Enno Hartmann, Gülsah Gabriel
Publikováno v:
Cell Reports, Vol 43, Iss 4, Pp 114023- (2024)
Externí odkaz:
https://doaj.org/article/ae73ceb0ca434ca7aaaeca856302775f
Autor:
Mohamed E. Elsesy, Su Jung Oh‐Hohenhorst, Christoph Oing, Alicia Eckhardt, Susanne Burdak‐Rothkamm, Malik Alawi, Christian Müller, Ulrich Schüller, Tobias Maurer, Gunhild vonAmsberg, Cordula Petersen, Kai Rothkamm, Wael Y. Mansour
Publikováno v:
Molecular Oncology, Vol 17, Iss 6, Pp 1129-1147 (2023)
The use of mutation analysis of homologous recombination repair (HRR) genes to estimate PARP‐inhibition response may miss a larger proportion of responding patients. Here, we provide preclinical models for castration‐resistant prostate cancer (CR
Externí odkaz:
https://doaj.org/article/de640423cfee4a5e9ddaf1dec52ce8c8
Autor:
Ifey Alio, Raphael Moll, Tim Hoffmann, Uwe Mamat, Ulrich E. Schaible, Kai Pappenfort, Malik Alawi, Marcel Schie, Roland Thünauer, Johanna Stamm, Holger Rohde, Wolfgang R. Streit
Publikováno v:
Microbiology Spectrum, Vol 11, Iss 6 (2023)
ABSTRACT Stenotrophomonas maltophilia is an emerging lung pathogen. In its natural habitat, it lives together with Pseudomonas aeruginosa, Staphylococcus aureus, and other pathogens. Here, we provide the first evidence that S. maltophilia interferes
Externí odkaz:
https://doaj.org/article/57400bd64a3442158687fd416368cedd
Autor:
Joanna Kempska, Leticia Oliveira-Ferrer, Astrid Grottke, Minyue Qi, Malik Alawi, Felix Meyer, Kerstin Borgmann, Fabienne Hamester, Kathrin Eylmann, Maila Rossberg, Daniel J. Smit, Manfred Jücker, Elena Laakmann, Isabell Witzel, Barbara Schmalfeldt, Volkmar Müller, Karen Legler
Publikováno v:
Frontiers in Oncology, Vol 13 (2023)
IntroductionThe PI3K/AKT pathway is activated in 43-70% of breast cancer (BC)-patients and promotes the metastatic potential of BC cells by increasing cell proliferation, invasion and radioresistance. Therefore, AKT1-inhibition in combination with ra
Externí odkaz:
https://doaj.org/article/7882ba2141484a4e949b72c38b608411
Autor:
Steven Schepanski, Mattia Chini, Veronika Sternemann, Christopher Urbschat, Kristin Thiele, Ting Sun, Yu Zhao, Mareike Poburski, Anna Woestemeier, Marie-Theres Thieme, Dimitra E. Zazara, Malik Alawi, Nicole Fischer, Joerg Heeren, Nikita Vladimirov, Andrew Woehler, Victor G. Puelles, Stefan Bonn, Nicola Gagliani, Ileana L. Hanganu-Opatz, Petra C. Arck
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
During pregnancy, maternal cells are transferred to the fetus, where they can reach the developing brain. In this study, the authors demonstrate that these maternal cells play an important role in neurodevelopment.
Externí odkaz:
https://doaj.org/article/f28f78dbe76547abbc4cadf7463e2b41
Autor:
Julia Elrod, Moritz Lenz, Antonia Kiwit, Lina Armbrust, Lavinia Schönfeld, Konrad Reinshagen, Laia Pagerols Raluy, Christoph Mohr, Ceren Saygi, Malik Alawi, Holger Rohde, Martin Herrmann, Michael Boettcher
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
IntroductionSevere burns cause unique pathophysiological alterations especially on the immune system. A murine scald model was optimized as a basis for the understanding of immunological reactions in response to heat induced injury. The understanding
Externí odkaz:
https://doaj.org/article/2c6d9ffe474d4aa49156c95206de0a9b
Vertically transferred maternal immune cells promote neonatal immunity against early life infections
Autor:
Ina Annelies Stelzer, Christopher Urbschat, Steven Schepanski, Kristin Thiele, Ioanna Triviai, Agnes Wieczorek, Malik Alawi, Denise Ohnezeit, Julian Kottlau, Jiabin Huang, Nicole Fischer, Hans-Willi Mittrücker, Maria Emilia Solano, Boris Fehse, Anke Diemert, Felix R. Stahl, Petra Clara Arck
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Maternal immune cells seed into the foetus during mammalian pregnancy, yet the functional role of these cells is unclear. Here the authors show that maternal immune cells in foetal bone marrow stimulate immune development, subsequently reducing the r
Externí odkaz:
https://doaj.org/article/8088a7cf93724a69801b759e6eac591e
Autor:
Malte Mohme, Cecile L. Maire, Simon Schliffke, Simon A. Joosse, Malik Alawi, Jakob Matschke, Ulrich Schüller, Judith Dierlamm, Tobias Martens, Klaus Pantel, Sabine Riethdorf, Katrin Lamszus, Manfred Westphal
Publikováno v:
Acta Neuropathologica Communications, Vol 8, Iss 1, Pp 1-13 (2020)
Abstract Peripheral metastases of glioblastoma (GBM) are very rare despite the ability of GBM cells to pass through the blood-brain barrier and be disseminated through the peripheral blood. Here, we describe a detailed genetic and immunological chara
Externí odkaz:
https://doaj.org/article/af5e7fd562514538833c9008e7c88964